Isabelle Mothe-Satney was born in Caen, France in 1968. She obtained a postgraduate degree (1 year) in pharmacology from the University of Nice-Sophia Antipolis, France, and a Ph.D. degree in life sciences (biochemistry, molecular Biology, and endocrinology) from the same University in 1997. From 1998 to 2000, she served as a Research Fellow at University of Virginia, USA, in the Laboratory of John C. Lawrence Jr. Her main research interest was the study of the role of the phosphorylation sites of the translational repressor 4E-BP1 (eIF4E-Binding Protein 1) in the regulation of insulin-stimulated protein synthesis. Then, she obtained a tenured position as a Research Associate at INSERM, in the Laboratory of E. Van Obberghen, INSERM Unit 145, Nice, France. From 2001 to 2007, she developed in this laboratory a research project about the role and the regulation of mTOR (mammalian target of rapamycin) in response to insulin and amino acids and in physiological and pathophysiological states associated with insulin resistance (obesity and type 2 Diabetes). Since 2008, she has been working at INSERM Unit 907, Nice, France, directed by Dr. Paul Grimaldi. She has extended her study of the mTOR pathway in other models including age-related sarcopenia and the regulation of this pathway in response to a variety of nutritional interventions (leucine, fatty acids, etc.).
Biography Updated on 30 September 2010