Douglas A. Weigent

University of Alabama at Birmingham, USA

Douglas A. Weigent was born in Seattle, USA in 1948. He received his B.S. degree in biology from Western Washington University and the M.A and Ph.D. degrees from the Department of Microbiology and Immunology from the University of Washington in 1972 and 1976, respectively. His postdoctoral training was completed at the University of Minnesota and the University of Texas Medical Branch in Galveston. He joined the Faculty at the University of Alabama at Birmingham (UAB) in 1986 and presently serves as a Professor at the Department of Physiology and Biophysics at UAB. The primary aim of his research program in immunoendocrinology is to determine the biological significance of growth hormone (GH) and growth hormone releasing hormone (GHRH) production by cells of the immune system. The major objectives of his present research are to determine the factors governing the production of lymphocyte GH and GHRH, to determine the differences or similarities in the GH and GHRH mRNA in lymphocytes versus pituitary cells, to identify the GH and GHRH producer cells, to determine the autocrine/paracrine effects of lymphocyte GH and GHRH on cytokine synthesis, antibody synthesis, and apoptosis in the immune system, and to determine whether GH and GHRH are produced during invasion of the host by viruses, bacteria, or tumors, and whether this same substance can restore deficiencies in immune deficient animals.

Biography Updated on 21 March 2011

Scholarly Contributions [Data Provided by scopus]