Prof Palaniyar, MSc., PhD., is a Senior Scientist at The Hospital for Sick Children and an Associate Professor at the University of Toronto, located in Toronto, ON, Canada. Palaniyar attended University of Guelph, Canada and studied Molecular Biology and Genetics and earned a Doctorate degree in 1997. He then conducted postdoctoral work on innate immunity of the lungs (SP-A, SP-D), electron miccroscopy, University of Guelph, 1997-1998; University of Cincinnati, OH, USA, 1999-2000; Immunochemistry - collectin-DNA interactions, apoptosis, apoptotic cell clearance, University of Oxford, UK, 2000-2004; Neutrophil extracellular traps, apoptotic cell clearance, stem cell transplant-related lung complications, SickKids/University of Toronto since 2004. He focuses on influenza virus A (flu), cystic fibrosis and other infectious and inflammatory lung diseases. He particularly studies soluble innate immune collectins such as mannose binding lectin MBL, Collectin 11, pulmonary surfactant proteins SP-A and SP-D. He aims to understand the roles of these proteins in neutrophil extracellular trap (NET)-mediated antimicrobial functions, cell death (apoptosis), dead cell clearance (efferocytosis), microbial infection (bacteria such as Staphyloccocus aureus, Pseudomonas aeruginosa, and virus such as influenza A virus) of the lungs, and inflammatory lung diseases - for example cystic fibrosis and pulmonary alveolar proteinosis. He also studies the lung complication arising from stem cell transplantation in children. Overall translational goal of his research work is to determine the therapeutic value of collectins in treating infectious and inflammatory lung diseases.
Biography Updated on 12 June 2014