Yuan Soon Ho was born in 12 June, 1965. He studied for his Ph.D. degree in biochemistry at the National Taiwan University, College of Medicine, Taipei, Taiwan, from 1990 till 1994. Ho is a Professor at the Graduate Institute of Biomedical Technology, Translational Cancer Research Center, Taipei Medical University, Taipei, Taiwan. His recent study demonstrated that the expression levels of the a9-nicotinic acetylcholine receptor (a9-nAChR) in breast cancer tissues were very high (>8-fold higher than the level in normal tissue) in Taiwanese patients (n=276), particularly in the tissues of late-stage patients (stages 3-4). Such results provide molecular evidence for smoking-induced breast cancer formation. In an accompanying editorial, Ilona Linnoila, M.D., of the Center for Cancer Research at the National Cancer Institute wrote that the study suggests not only that smoking could be causally related to breast carcinogenesis but also that nicotine could directly contribute to the molecular mechanism of carcinogenesis in addition to indirectly contributing by promoting addiction to smoking. Thus, these findings further emphasize that blocking nicotinic receptors may act as an effective strategy for the prevention of breast cancer.
Biography Updated on 23 October 2011