Eniko A. Kramar
Eniko A. Kramar is a Senior Researcher at the Department of Anatomy and Neurobiology at the University of California Irvine, Calif, USA. She received her Ph.D. degree from the Washington State University, Pullman, Wash, USA, and then continued her postdoctoral work at the School of Medicine, University of California Irvine, Calif, USA. Supported by a NIH Postdoctoral Fellowship, Kramar made a series of discoveries showing that adhesion receptors belonging to the integrin family play a critical role in the consolidation (as opposed to induction and initial expression) of long-term potentiation (LTP). Using a method she helped invent, Kramar then found that integrins exert their consolidation effects by promoting the stabilization of actin networks that form shortly after LTP induction. Following her promotion to an Assistant Researcher position in 2003, she expanded her research program to include the question of whether integrins interact with releasable "synaptic modifiers" to regulate the cytoskeletal changes underlying consolidation. This collaborative work ultimately resulted in the first clear descriptions of how brain-derived neurotrophic factor (BDNF) and adenosine modulate LTP consolidation. Kramar briefly left academia in 2005 to accept a position in industry and when she returned in 2007 as a Senior Researcher (UCI) she initiated a new research program testing if the plasticity and memory losses associated with low levels of estrogen can be explained within her model of LTP consolidation. These experiments led to the proposal that estrogen is itself synaptic modifier acting positively on the same actin signaling pathways suppressed by adenosine. They have also pointed to a novel therapeutic strategy for offsetting the plasticity deficits that accompany conditions (e.g., menopause) in which estrogen levels are chronically depressed. She has recently served as a Wellcome Trust Scientific Reviewer.
Biography Updated on 26 June 2012