Thomas LaFramboise earned his B.S. degree from the University of Michigan at Ann Arbor and his Ph.D. degree from the University of Illinois at Urbana-Champaign, USA, with both degrees in theoretical mathematics. Subsequently, he spent several years as an Assistant and Associate Professor at the Mathematics Department at Marietta College in Marietta, Ohio. In 2002, LaFramboise decided to retrain in biostatistics, earning an M.S. degree from the Harvard School of Public Health, which led to a postdoctoral position in cancer genomics at the Laboratory of Matthew Meyerson at the Dana-Farber Cancer Institute and the Broad Institute of Harvard and MIT. He joined the Case Western University Department of Genetics in 2006. Broadly, LaFramboise is interested in developing and applying computational tools to identify molecular variants —both inherited and somatic— that contribute to cancer and related diseases in humans. His postdoctoral work centered on the statistical modeling of data from SNP microarrays to detect DNA copy number changes in tumors, and he has written a number of R software packages designed to draw biological inferences from genomic data. His group is currently developing and applying methods to mine high-dimensional data sets, with the goal of generating hypotheses regarding gene function in tumor initiation, progression, and metastasis. They then test these hypotheses in the laboratory using human cancer cells.
Biography Updated on 4 September 2011