Dorien Peters holds a Ph.D. degree. From 1991 to 1999, he was a Postdoctoral Professor at the Department of Human Genetics, Leiden University. From 1999 to 2000, he was an Assistant Professor at the Department of Human Genetics, Leiden University Medical Center. Since 2000, he has been an Associate Professor at the Department of Human Genetics, Leiden University Medical Center. His main focus of research is to get insight into the pathophysiology of autosomal dominant polycystic kidney disease (ADPKD) with the aim to develop therapeutic interventions. This research now concentrates on three lines of investigation. First, cell biological/biochemical research using knock-out cell lines or RNAi-transfected cells and cells transfected with (parts) of the PKD-genes is performed to obtain insight in the function of the encoded proteins in vitro. A focus is on the effects of cilia/centromere function as a result of fluid flow. Second is the analysis of polycystins expression and functions in vivo. A variety of Pkd1 mouse models have been generated and used to study pathophysiology, and they are testing the efficacy of therapeutic interventions on pathology as well as gene expression and signal transduction. Third are the genetic studies in ADPKD families. They participate in a multicenter study to analyze the progression of ADPKD, renal failure, and complications of the disease and establish whether modifying genes exist and to identify those genes. In addition, he is studying the genetics of malformation syndromes, particularly the Rubinstein-taybi syndrome.
Biography Updated on 30 December 2010