Mario Marchi holds the M.D. and Ph.D. degrees. He has a scientific experience of more than 30 years in the study of several aspects of central neurotransmission. He is a Professor of pharmacology at the Department of Experimental Medicine, University of Genova, Italy. Marchi is a neuropharmacologist who worked, during the past decades, in the field of cholinergic mechanisms. He started working on the development and aging of cholinergic synapses in the central and peripheral nervous system since the late-1970s when he joined the laboratory of Dr. Giacobini as a Visiting Scientist at the Department of Biobehavioral Sciences of the University of Connecticut. In the early-1980s, pioneer in the studies on presynaptic receptors modulating neurotransmitter release, his group discovered and characterized, in rats and in humans, the presynaptic muscarinic M2 autoreceptors which control ACh release in the CNS and show the existence of multiple presynaptic muscarinic receptors which are functionally and pharmacologically distinct. More recently, his research group studied the functional role of several nicotinic receptor subtypes, present on different nerve terminals, demonstrating the functional coexistence of these receptors with other receptors present on the same terminal. Another contribution of his research group concerns the field of neuronal plasticity with their studies on the functional changes of the pre- and postsynaptic receptors after chronic drug treatments or due to an enriched environment.
Biography Updated on 9 April 2012