Marieke Coenen is an Assistant Professor at the Department of Human Genetics of the Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. Her research entails population-based gene-finding studies, construction of genetic prediction models, and cost-effectiveness analyses of pharmacogenetic tests. The gene-finding research focuses on rheumatoid arthritis disease progression and treatment of patients with biologicals. Her main focus is to develop a prediction model to personalize treatment of rheumatoid arthritis patients treated with the biological anti-tumour necrosis factor. In addition, Coenen is involved in research directed at unraveling the genetic background of common autoimmune diseases (such as RA, psoriasis, celiac disease and systemic sclerosis) and pharmacogenetic analysis directed to optimise treatment of children with osteosarcoma and leukemia. Concerning cost-effectiveness analyses, Coenen leads a national randomized controlled trial for cost-effectiveness of thiopurine-S-methyltransferase genotyping prior to thiopurine treatment in patients with inflammatory bowel disorders. In addition to the pharmacogenetic studies she is also involved in research related to the genetic background of pain sensitivity and chronification and the treatment of pain.
Biography Updated on 23 May 2012