Zhiping Ye works as a Senior Investigator in Center for Biologics Evaluation and Research, Food and Drug Administration (FDA), USA. He received his Ph.D. degree in virology from the Department of Microbiology, University of Virginia, School of Medicine, Va, USA and his M.D. degree in medicine from Shanghai First Medical University, Shanghai, China. Dr. Ye has over 20 years of research experience in molecular virology and influenza vaccines. In 1983, he worked at Dr. Chi-Ming Chu’s laboratory in the Institute of Virology, Beijing, China, where he has been involved in studying epidemiology of influenza and development of influenza vaccine in China. In Dr. Robert Wagner’s laboratory at the University of Virginia, he worked extensively with influenza virus and vesicular stomatitis virus. Dr. Ye has initiated and completed novel research in the field of influenza viruses. Since coming to the FDA in 1998, Dr. Ye has worked on the influenza research program with respect to influenza vaccine development and use. In addition, he and his research team refined his earlier investigations of influenza virus matrix protein structure-function relations and has since performed novel and field-leading studies. Their research effort has been facilitated by the introduction of powerful, modern molecular tools, and in particular the method termed “reverse genetics.” Reverse genetics makes it possible to introduce specific changes in domains of interest in influenza virus proteins and examine the characteristics of the viable output viruses. Using this technique, Dr. Ye has explored the role of the influenza genes in viral replication and morphogenesis. His research program includes the development of molecular techniques for influenza vaccine, thus providing knowledge to improve the safety and efficacy of influenza virus vaccines. Since 2001, Dr. Ye has been a Temporary Advisor, representing FDA, for World Health Organization Annual Consultation on the Composition of Influenza Vaccine Update.
Biography Updated on 3 April 2012