Giuseppina De Simone

Istituto di Biostrutture e Bioimmagini-Consiglio Nazionale delle Ricerche, Italy 0000-0001-9783-5431

Giuseppina De Simone was born in 1970 in Naples, Italy. She studied chemistry and graduated from the University of Naples Federico II, Naples, Italy, in 1993. She worked from August 1994 to January 1995 at the drug design group, Sandoz Pharma AG in Basel, and from September 1995 to February 1996 at the University of Pavia, Lombardy, Italy. From November 1996 to January 1997, she served as a Visiting Scientist at the Max Planck Institute, Hamburg, Germany. In 1998, she received her Ph.D. degree at the University of Naples. Since 2003, she has been a Senior Researcher at the Bioimaging and Biostructure Institute (IBB) of the Italian National Research Council. The research activities of Dr. De Simone are focused on several aspects of structure and function relationships in macromolecules with a biological interest. Her studies have been dedicated to a variety of macromolecular systems with different structural complexities and have been carried out by combining X-ray crystallographic methods with several other techniques, including enzyme expression and purification, enzyme functional characterization, molecular modeling, and kinetic and spectroscopic analysis. Over the last years, in collaboration with a framework of international institutions, her research has been mainly dedicated to the structural characterization of enzymes involved in human diseases as well as the design and characterization of small molecules able to modulate their activity. Dr. De Simone is the author of more than 80 scientific publications on international journals among which are Proceedings of the National Academy of Sciences and Nature Cell Biology. She has been the Principal Investigator of several research grants from national (CNR, Regione Campania) and international (EU, Solvay Pharmaceuticals) institutions. Currently, Dr. De Simone is an Associate Editor of The Open Enzyme Inhibition Journal and Journal of Enzyme inhibition and Medicinal Chemistry.

Biography Updated on 15 August 2012

Scholarly Contributions [Data Provided by scopus]

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