Ali Ouaissi
Ali Ouaissi received the M.A. degree from the University of Paris VI in 1974 and the Ph.D. and D.S. degrees from the University of Lille, France, in 1977 and 1980, respectively. He has published widely in the areas of molecular biology and immunology of parasitic diseases with over 130 articles and several book chapters. He was a Senior Investigator (1977–1982); Scientist in charge of research teams, Institut National de la Santé et de la Recherche Médicale (INSERM), research unit no. 167, during 1992–1989; Director of research at INSERM (1989 unitl present); Head of CJF INSERM, no. 96-04 (1996–2000), Faculty of Medicine, Montpellier, France; and Head of Institut de Recherche pour le Développement (IRD), research unit no. 008, “Trypanosomatids Pathogeny” (2001–2007). His research has received financial support from National (INSERM and Medical Research Foundation) and International (WHO, EEC, Indo-French Centre for the Promotion of Advanced Research, IFCPAR) institutions. He contributed since several years to the magisterial teachings of parasite immunology and molecular biology. He served as a Supervisor of 18 Ph.D. theses and 13 M.A. degrees. He was a Vice President of the “INSERM Nord-Pas de Calais-Grand Ouest” of the Regional Advisory Scientific Counsel (CSCRI) during 1993–1995. He serves as a member of the Scientific Commission no. 2 of IRD (2003–2007), a member of the Regional Ethical Committee of Animal Experimentation (2002–2009), and a member of the Administrative Council of the French Society of Immunology (2005–2007). He is an Expert consulted by international scientific journals and is an Associate Editor of the Journal of Biomedicine and Biotechnology, and a Guest Editor of the Special Issue on Immunology and Molecular Biology of Protozoan Infections.
Biography Updated on 17 March 2008
Articles in Scholarly Journals [Incomplete List]
- Advances and perspectives in Leishmania cell based drug-screening procedures
Parasitology International, vol. 56, no. 1, pp. 3–7, 2007 - Comparative evaluation of therapeutic DNA vaccines against Trypanosoma cruzi in mice
FEMS Immunology & Medical Microbiology, vol. 50, no. 3, pp. 333–341, 2007 - Immunology and Molecular Biology of Protozoan Infections
Journal of Biomedicine and Biotechnology, vol. 2007, Article ID 67210, 1 pages, 2007 - Regulatory Cells and Immunosuppressive Cytokines:
Parasite-Derived Factors Induce Immune Polarization
Journal of Biomedicine and Biotechnology, vol. 2007, Article ID 94971, 10 pages, 2007 - Histone Deacetylase Enzymes as Potential Drug Targets in Cancer and Parasitic Diseases
Journal of Biomedicine and Biotechnology, vol. 2006, Article ID 13474, 10 pages, 2006 - Leishmania cytosolic silent information regulatory protein 2 deacetylase induces murine B-cell differentiation and in vivo production of specific antibodies
Immunology, vol. 119, no. 4, pp. 529–540, 2006 - Looking for putative functions of the Leishmania cytosolic SIR2 deacetylase
Parasitology Research, vol. 100, no. 1, pp. 1–9, 2006 - Proof of interaction between Leishmania SIR2RP1 deacetylase and chaperone HSP83
Parasitology Research, vol. 100, no. 4, pp. 811–818, 2006 - Kinetoplastid Biology and Disease, vol. 5, no. 1, p. 6, 2006
- Kinetoplastid Biology and Disease, vol. 4, no. 1, p. 1, 2005
- Conversion of Tc52 released factor to a protein inducing apoptosis
Tissue and Cell, vol. 37, no. 6, pp. 469–478, 2005 - Targeted disruption of cytosolic SIR2 deacetylase discloses its essential role in survival and proliferation
Gene, vol. 363, pp. 85–96, 2005 - Differential effects of polyamine derivative compounds against promastigotes and axenic amastigotes
International Journal for Parasitology, vol. 35, no. 6, pp. 637–646, 2005 - Antibodies against a peroxiredoxin as a possible marker for diagnosis of visceral leishmaniasis and for monitoring the efficacy of treatment
Immunology Letters, vol. 101, no. 1, pp. 18–23, 2005 - Stage-specific antileishmanial activity of an inhibitor of SIR2 histone deacetylase
Acta Tropica, vol. 94, no. 2, pp. 107–115, 2005 - In Vitro Antileishmanial Activity of Nicotinamide
Antimicrobial Agents and Chemotherapy, vol. 49, no. 2, pp. 808–812, 2005 - Differential infectivity and immunopathology in murine experimental infections by two natural clones belonging to the Trypanosoma cruzi I lineage
Parasitology, vol. 131, no. 1, pp. 109–119, 2005 - Host Cell Phenotypic Variability Induced by Trypanosomatid-Parasite-Released Immunomodulatory Factors: Physiopathological Implications
Journal of Biomedicine and Biotechnology, vol. 2004, no. 3, pp. 167–174, 2004 - Entérocolite nécrosante en fin de grossesse chez une femme opérée à l'âge de six mois d'une maladie de Hirschsprung
Annales de Chirurgie, vol. 129, no. 1, pp. 34–36, 2004 - Immunological alterations induced by polyamine derivatives on murine splenocytes and human mononuclear cells
International Immunopharmacology, vol. 4, no. 4, pp. 547–556, 2004 - Traitement cœlioscopique d'une polykystose pancréatiqueCœlioscopic treatment of pancreatic polycystic disease
Annales de Chirurgie, vol. 128, no. 2, pp. 109–111, 2003 - Kinetoplastid Biology and Disease, vol. 2, no. 1, p. 5, 2003
- Peptide-based analysis of the amino acid sequence important to the immunoregulatory function of Trypanosoma cruzi Tc52 virulence factor
Immunology, vol. 109, no. 1, pp. 147–155, 2003 - Fatal bowel infarction due to aspergillosis after chemotherapy
European Journal of Surgical Oncology, vol. 29, no. 7, p. 628, 2003 - Identification of antibodies to Leishmania silent information regulatory 2 (SIR2) protein homologue during canine natural infections: pathological implications
Immunology Letters, vol. 86, no. 2, pp. 155–162, 2003 - Trypanosoma cruzi carrying a targeted deletion of a Tc52 protein-encoding allele elicits attenuated Chagas' disease in mice
Immunology Letters, vol. 89, no. 1, pp. 67–80, 2003 - isoenzyme variability in Ecuador: first observation of zymodeme III genotypes in chronic chagasic patients
Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 96, no. 4, pp. 378–382, 2002 - Glutathione S-transferases and related proteins from pathogenic human parasites behave as immunomodulatory factors
Immunology Letters, vol. 81, no. 3, pp. 159–164, 2002 - Cytoplasmic SIR2 homologue overexpression promotes survival of Leishmania parasites by preventing programmed cell death
Gene, vol. 296, no. 1-2, pp. 139–150, 2002 - Traitement chirurgical de l'incontinence analeSurgical treatment of anal incontinence
Annales de Chirurgie, vol. 127, no. 9, pp. 670–679, 2002 - Experimental studies on the evolution of antimony-resistant phenotype during the in vitro life cycle of Leishmania infantum: implications for the spread of chemoresistance in endemic areas
Acta Tropica, vol. 80, no. 3, pp. 195–205, 2001 - Endogenous Trypanosoma cruzi Tc52 protein expression upregulates the growth of murine macrophages and fibroblasts and cytokine gene expression
Immunology Letters, vol. 78, no. 3, pp. 127–134, 2001 - Antimonial-Mediated DNA Fragmentation in Leishmania infantum Amastigotes
Antimicrobial Agents and Chemotherapy, vol. 45, no. 7, pp. 2064–2069, 2001 - Dual Role of the Leishmania major Ribosomal Protein S3a Homologue in Regulation of T- and B-Cell Activation
Infection and Immunity, vol. 69, no. 11, pp. 6588–6596, 2001 - Trypanosoma Cruzi-Induced Host Immune System Dysfunction: A Rationale for Parasite Immunosuppressive Factor(s) Encoding Gene Targeting
Journal of Biomedicine and Biotechnology, vol. 1, no. 1, pp. 11–17, 2001 - N-Acetylcysteine and glutathione modulate the behaviour of Trypanosoma cruzi experimental infection
Immunology Letters, vol. 71, no. 2, pp. 79–83, 2000 - Identification and molecular characterization of two novel Trypanosoma cruzi genes encoding polypeptides sharing sequence motifs found in proteins involved in RNA editing reactions
Gene, vol. 253, no. 2, pp. 271–280, 2000 - Cloning of a Leishmania major gene encoding for an antigen with extensive homology to ribosomal protein S3a
Gene, vol. 240, no. 1, pp. 57–65, 1999 - Intracellular growth and metacyclogenesis defects in Trypanosoma cruzi carrying a targeted deletion of a Tc52 protein-encoding allele
Molecular Microbiology, vol. 32, no. 6, pp. 1273–1286, 1999 - A 24 000 MW Trypanosoma cruzi antigen is a B-cell activator
Immunology, vol. 94, no. 2, pp. 189–196, 1998 - Leishmania major: Cell type dependent distribution of a 43 kDa antigen related to silent information regulatory-2 protein family
Biology of the Cell, vol. 90, no. 3, pp. 239–245, 1998 - Phenotype of recombinant Trypanosoma cruzi which overexpress elongation factor 1-?: possible involvement of EF-1? GST-like domain in the resistance to clomipramine
Gene, vol. 198, no. 1-2, pp. 259–267, 1997 - A Leishmania major protein with extensive homology to silent information regulator 2 of Saccharomyces cerevisiae
Gene, vol. 169, no. 1, pp. 115–118, 1996 - Trypanosoma cruzi elongation factor 1-a: nuclear localization in parasites undergoing apoptosis
Gene, vol. 174, no. 1, pp. 19–26, 1996 - 2-Amino diphenylsulfides as new inhibitors of trypanothione reductase
International Journal of Antimicrobial Agents, vol. 6, no. 2, pp. 111–118, 1995 - High Circulating Levels of Fibronectin and Antibodies against Its RGD Adhesion Site during Mouse Trypanosoma cruzi Infection: Relation to Survival
Experimental Parasitology, vol. 80, no. 3, pp. 499–506, 1995 - Trypanosoma cruzi: A 52-kDa Protein Sharing Sequence Homology with Glutathione S-Transferase Is Localized in Parasite Organelles Morphologically Resembling Reservosomes
Experimental Parasitology, vol. 81, no. 4, pp. 453–461, 1995 - Use of a recombinant Trypanosoma cruzi protein antigen to monitor cure of Chagas disease
Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 89, no. 4, pp. 447–448, 1995 - A novel and basic mechanism of immunosuppression in Chagas' disease: releases in vitro and in vivo a protein which induces T cell unresponsiveness through specific interaction with cysteine and glutathione
Immunology Letters, vol. 48, no. 3, pp. 221–224, 1995 - : Analysis of cellular and humoral response against a protective recombinant antigen during experimental Chagas' disease
Immunology Letters, vol. 48, no. 3, pp. 193–200, 1995 - Molecular cloning of aTrypanosoma cruzi cDNA encoding a protein homologous with mammalian elongation factor 1?
Parasitology Research, vol. 80, no. 7, pp. 626–628, 1994 - Trypanosoma cruzi cDNA encodes a tandemly repeated domain structure characteristic of small stress proteins and glutathione S-transferases
Biology of the Cell, vol. 80, no. 1, pp. 1–10, 1994 - Molecular and immunological characterization of a Trypanosoma cruzi protein homologous to mammalian elongation factor 1 gamma
Biology of the Cell, vol. 82, no. 1, pp. 39–44, 1994 - glutathione-binding proteins (TcGBP) : protection induced by native proteins in an experimental model and analysis of the antibody response
Research in Immunology, vol. 144, no. 8, pp. 553–563, 1993 - attachment of from mouse and rat origin
Biology of the Cell, vol. 77, pp. 209–217, 1993 - Cloning and sequencing of a 24-kDa Trypanosoma cruzi specific antigen released in association with membrane vesicles and defined by a monoclonal antibody
Biology of the Cell, vol. 75, no. 1, pp. 11–17, 1992 - Trypanosoma cruzi: Infection of T lymphocytes and their destruction by antibody-dependent cell-mediated cytotoxicity
European Journal of Immunology, vol. 21, no. 9, pp. 2145–2152, 1991 - Trypanosoma cruzi: Differential expression and distribution of an 85-kDa polypeptide epitope by in vitro developmental stages
Experimental Parasitology, vol. 71, no. 2, pp. 207–217, 1990 - Some aspects of protozoan parasite-host cell interactions with special reference to RGD-mediated recognition process
Microbial Pathogenesis, vol. 6, no. 1, pp. 1–5, 1989 - Role of the RGD sequence in parasite adhesion to host cells
Parasitology Today, vol. 4, no. 6, pp. 169–173, 1988 - The major surface protein ofleishmania promastigotes is a fibronectin-like molecule
European Journal of Immunology, vol. 18, no. 3, pp. 473–476, 1988 - Identification of anti-acetylcholinesterase and anti-idiotype antibodies in human and experimental Chagas+ disease: pathological implications
European Journal of Immunology, vol. 18, no. 12, pp. 1889–1894, 1988 - Fluorescence-Activated Cell-Sorting Analysis of Fibronectin Peptides Binding to Trypanosoma cruzi Trypomastigotes
The Journal of Eukaryotic Microbiology, vol. 35, no. 1, pp. 111–114, 1988 - Trypanosoma cruzi: Ultrastructural visualization of fibronectin bound to culture forms
Experimental Parasitology, vol. 63, no. 1, pp. 112–114, 1987 - Trypanosoma cruzi: Cell type dependent distribution of a tubulin domain in mammalian stages
Experimental Parasitology, vol. 64, no. 2, pp. 133–138, 1987 - Identification and isolation of Trypanosoma cruzi trypomastigote cell surface protein with properties expected of a fibronectin receptor
Molecular and Biochemical Parasitology, vol. 19, no. 3, pp. 201–211, 1986 - Trypanosoma cruzi: modulation of parasite-cell interaction by plasma fibronectin
European Journal of Immunology, vol. 15, no. 11, pp. 1096–1101, 1985 - Fibronectin receptors on Trypanosoma cruzi trypomastigotes and their biological function
Nature, vol. 308, no. 5957, Article ID 308380a0, 2 pages, 1984 - Schistosoma mansoni: Ultrastructural damages due to complement on schistosomula in vitro
Experimental Parasitology, vol. 50, no. 1, pp. 74–82, 1980 - Interaction between Schistosoma mansoni and the complement system. Receptors for C3b on cercariae and schistosomula
Immunology Letters, vol. 1, no. 4, pp. 197–201, 1980 - Freeze-fracture study of immune-induced Schistosoma mansoni membrane alterationsI. Complement-dependent damage in the presence of antisera to host antigenic Determinants
Journal of Ultrastructure Research, vol. 67, no. 3, pp. 276–287, 1979 - Receptor for IgG(Fc) and human ß2-microglobulin on S. mansoni schistosomula
Nature, vol. 278, no. 5703, Article ID 278447a0, 2 pages, 1979