Alberto d'Onofrio works as the Principal Investigator in systems biomedicine at the Department of Experimental Oncology of the European Institute of Oncology, Milan, Italy. He received in 1993 the M.S. degree in electrical engineering and control theory from Pisa University and in 2000 his Ph.D. degree in medical computer sciences from the La Sapienza University in Rome. His research is focused on the application of a wide spectrum of computational and analytical tools of physics and nonlinear mathematics in both basic science of cancer and clinical oncology. Indeed, tumors are a family of highly dynamical diseases, so that the nonlinear kinetics of tumor onset and growth shapes both the natural history of neoplasias and their responses to treatments. Moreover, a tumor cell, in itself a highly complex nonlinear biochemical engine, substantially interacts with its microenvironment, and its nonlinear ecological interplay with other systems (e.g., immune system effectors and antibodies, blood vessels, etc.) determines its fate. Another research interest is the mathematical modeling of the spread and vaccine-based control of infectious diseases, with a focus on the role of information as indirect feedback modulating the dynamics of the infectious spread. d’Onofrio is also a Member of the Editorial Board of (JOTA), Journal of Optimization: Theory and Applications, and is the Author of 65 peer-reviewed publications in ISI-indexed journals and books.
Biography Updated on 4 October 2011