George Perry

George Perry obtained his bachelor of arts in zoology with high honors from the University of California at Santa Barbara in 1974 and completed his Ph.D. degree in marine biology from the Scripps Institution of Oceanography, University of California, San Diego, in 1979. After postdoctoral studies in cell biology at Baylor College of Medicine, Dr. Perry joined the faculty of Case Western Reserve University in 1982 as an Assistant Professor and has been a Professor since 1994. He was named Fellow by the American Association for the Advancement of Science in 1998. From 2001 through 2005, he was the Interim Chair of the Department of Pathology at Case and has since become the Dean of the College of Sciences at the University of Texas at San Antonio as of January 2006. Besides his roles as Dean and Professor, Dr. Perry is very active with editorial work and is an internationally known invited Lecturer and has numerous papers, presentations, and publications to his credit. Dr. Perry’s studies are focused on the mechanism of formation and physiological consequences of the cytopathology of Alzheimer disease. Dr. Perry’s group has shown that oxidative damage is the initial cytopathological abnormality in Alzheimer disease. The group is working to determine the sequence of events leading to neuronal oxidative damage and the source of the increased oxygen radicals. His current studies focus on three issues: (i) the metabolic basis for the mitochondrial damage restricted to vulnerable neurons; (ii) the consequences of RNA oxidation on protein synthesis rate and fidelity; and (iii) role of phosphorylation in controlling oxidative adduction.

Biography Updated on 16 March 2007

Articles in Scholarly Journals [Incomplete List]

  1. c-Jun phosphorylation in Alzheimer disease
    Journal of Neuroscience Research, vol. 85, no. 8, pp. 1668–1673, 2007
  2. Indices of Metabolic Dysfunction and Oxidative Stress
    Neurochemical Research, vol. 32, no. 4-5, pp. 717–722, 2007
  3. Alzheimer disease, the two-hit hypothesis: An update
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol. 1772, no. 4, pp. 494–502, 2007
  4. Vascular oxidative stress in Alzheimer disease
    Journal of the Neurological Sciences, vol. 257, no. 1-2, pp. 240–246, 2007
  5. Gonadotropins: A cohesive gender-based etiology of Alzheimer disease
    Molecular and Cellular Endocrinology, vol. 260-262, pp. 271–275, 2007
  6. Increases in luteinizing hormone are associated with declines in cognitive performance
    Molecular and Cellular Endocrinology, vol. 269, no. 1-2, pp. 107–111, 2007
  7. Autophagocytosis of Mitochondria Is Prominent in Alzheimer Disease
    Journal of Neuropathology and Experimental Neurology, vol. 66, no. 6, pp. 525–532, 2007
  8. Amyloid-beta in Alzheimer Disease: The Null versus the Alternate Hypotheses
    Journal of Pharmacology and Experimental Therapeutics, vol. 321, no. 3, pp. 823–829, 2007
  9. Cerebrotendinous xanthomatosis: case report with evidence of oxidative stress
    Redox Report, vol. 12, no. 3, pp. 119–124, 2007
  10. Molecular Neurodegeneration, vol. 2, no. 1, p. 2, 2007
  11. Identification of the Imprinted KLF14 Transcription Factor Undergoing Human-Specific Accelerated Evolution
    PLoS Genetics, vol. 3, no. 5, p. e65, 2007
  12. Neuropathology and treatment of Alzheimer disease: did we lose the forest for the trees?
    Expert Review of Neurotherapeutics, vol. 7, no. 5, pp. 473–485, 2007
  13. Prevention and Treatment of Alzheimer Disease and Aging: Antioxidants
    Mini Reviews in Medicinal Chemistry, vol. 7, no. 2, pp. 171–180, 2007
  14. Increased Expression of the Remodeling- and Tumorigenic-Associated Factor Osteopontin in Pyramidal Neurons of the Alzheimer's Disease Brain
    Current Alzheimer Research, vol. 4, no. 1, pp. 67–72, 2007
  15. Treating the Lesions, Not the Disease
    American Journal Of Pathology, vol. 170, no. 5, pp. 1457–1459, 2007
  16. Amyloid-  Vaccination: Testing the Amyloid Hypothesis?: Heads We Win, Tails You Lose!
    American Journal Of Pathology, vol. 169, no. 3, pp. 738–739, 2006