Daniel Little

Dan Little was born and raised in Superior, Wis, USA. He was educated at the Wisconsin State University-Superior (now UW-Superior) where he majored in chemistry and mathematics, the University of South Dakota (NSF research), Argonne National Laboratory (with Kaplan & Wilzbach), and the University of Wisconsin (WARF Fellow; Ph.D. with H.E. Zimmerman). In 1994, Dan was named an Outstanding Alumnus of UW-Superior. Following postdoctoral studies at Yale University (with J.A. Berson) Dan joined the faculty of the University of California, Santa Barbara, where he is a Professor in the Department of Chemistry & Biochemistry. Dan is a past Department Vice-Chair and Chair of the Department at UCSB, and was a Visiting Professor at the University of British Columbia. He is a member of several professional societies including the American Chemical Society and the Electrochemical Society. He has lectured in many countries around the world, most recently in Canada, Japan, and the Czech Republic. Dan has served on many review panels, particularly so for the National Science Foundation (NSF) and the National Institutes of Health (NIH). In addition to his role as an Associate Editor of Research Letters in Organic Chemistry, he is a member of the editorial board for Letters in Organic Chemistry. Dan’s research interests are wide, ranging from applications of quantum mechanics, to organic electrochemistry, to natural products chemistry. His group has made contributions in many areas including the development of synthetic methods (e.g., the MIRC reaction, the Stone-Little method for the preparation of fulvenes, the electroreductive cyclization reaction, the formation of alpha-C-glycosides), the chemistry of trimethylenemethane diyls, cation radicals, and anion radicals, and to the total synthesis of natural products (e.g., hirsutene, coriolin, hypnophilin, and desmethyl arteannunin B), as well as to organic electrochemistry.

Biography Updated on 12 November 2007

Personal Home Page

http://www.chem.ucsb.edu/~little_group/

Articles in Scholarly Journals [Incomplete List]

  1. A Highly Selective Rearrangement of a Housane-Derived Cation Radical: An Electrochemically Mediated Transformation
    The Journal of Organic Chemistry, vol. 72, no. 12, pp. 4351–4357, 2007
  2. The Journal of Organic Chemistry, vol. 71, no. 16, pp. 5936–5941, 2006
  3. The influence of electrogenerated Sm(II), electrogenerated Yb(II), and magnesium ions produced at a sacrificial magnesium anode, upon the diastereoselectivity of electroreductive cyclization reactions
    Journal of Electroanalytical Chemistry, 2006
  4. The positive effect of oxygenated solvents for the synthetic use of electroregenerated ytterbium(II)?
    Electrochimica Acta, vol. 50, no. 6, pp. 1383–1390, 2005
  5. The Journal of Organic Chemistry, vol. 70, no. 12, pp. 4598–4608, 2005
  6. The Journal of Organic Chemistry, vol. 70, no. 13, pp. 5249–5256, 2005
  7. The Journal of Organic Chemistry, vol. 69, no. 25, pp. 8574–8582, 2004
  8. Coping with substituent effects in divinylcyclopropyl diazene rearrangements
    Tetrahedron Letters, vol. 44, no. 10, pp. 2109–2112, 2003
  9. Erratum to “Coping with substituent effects in divinylcyclopropyl diazene rearrangements” [Tetrahedron Lett. 44 (2003) 2109]
    Tetrahedron Letters, vol. 44, no. 16, p. 3433, 2003
  10. Journal of the American Chemical Society, vol. 125, no. 13, pp. 3688–3689, 2003
  11. Organic Letters, vol. 5, no. 20, pp. 3615–3617, 2003
  12. Organic Letters, vol. 4, no. 9, pp. 1439–1442, 2002
  13. [3+2] versus [4+3] cycloaddition of conjugated dienes to TMM diradicals
    Tetrahedron Letters, vol. 43, no. 47, pp. 8459–8461, 2002
  14. Vinylcyclopropyl TMM diyls: access to eight-membered rings
    Tetrahedron Letters, vol. 42, no. 25, pp. 4095–4097, 2001
  15. Electrochemical generation of low-valent lanthanides
    Tetrahedron Letters, vol. 42, no. 44, pp. 7767–7770, 2001
  16. Electrochemical formation of glycals in THF
    Tetrahedron Letters, vol. 42, no. 42, pp. 7371–7374, 2001
  17. Journal of the American Chemical Society, vol. 123, no. 14, pp. 3289–3294, 2001
  18. Journal of Organic Chemistry, vol. 65, no. 23, pp. 8096–8099, 2000
  19. Organic Letters, vol. 2, no. 18, pp. 2873–2876, 2000
  20. Organic Letters, vol. 2, no. 16, pp. 2531–2534, 2000
  21. Interaction of cyclobutane with the Ru(001) surface: Low-temperature molecular adsorption and dissociative chemisorption at elevated surface temperature
    The Journal of Chemical Physics, vol. 110, no. 3, p. 1745, 1999
  22. Journal of Natural Products, vol. 62, no. 9, pp. 1349–1349, 1999
  23. TMM diyl-induced vinylcyclopropane fragmentation and recombination
    Tetrahedron Letters, vol. 39, no. 14, pp. 1893–1896, 1998
  24. Journal of the American Chemical Society, vol. 120, no. 45, pp. 11812–11813, 1998
  25. The Versatile Trimethylenemethane Diyl; Diyl Trapping Reactions - Retrospective and New Modes of Reactivity
    European Journal of Organic Chemistry, vol. 1998, no. 1, pp. 1–12, 1998
  26. The Versatile Trimethylenemethane Diyl; Diyl Trapping Reactions â?? Retrospective and New Modes of Reactivity
    European Journal of Organic Chemistry, vol. 1998, no. 1, pp. 1–12, 1998
  27. A modified electrochemical approach to diazenes
    Electrochimica Acta, vol. 42, no. 13-14, pp. 2201–2203, 1997
  28. Intermolecular diyl trapping reactions with allene diylophiles
    Tetrahedron Letters, vol. 38, no. 1, pp. 15–18, 1997
  29. Journal of Organic Chemistry, vol. 62, no. 11, pp. 3779–3781, 1997
  30. Journal of Organic Chemistry, vol. 62, no. 6, pp. 1610–1616, 1997
  31. An Improved Workup for Samarium (II) Iodide Reactions
    Synthetic Communications, vol. 27, no. 5, pp. 837–840, 1997
  32. Journal of Organic Chemistry, vol. 61, no. 5, pp. 1787–1793, 1996
  33. Journal of Organic Chemistry, vol. 61, no. 10, pp. 3240–3244, 1996
  34. Organometallic nucleophilic ring-opening of endo peroxides
    Tetrahedron Letters, vol. 37, no. 37, pp. 6635–6638, 1996
  35. Chemical Reviews, vol. 96, no. 1, pp. 93–114, 1996
  36. The binding modes of a rationally designed photoactivated DNA nuclease determined by NMR
    Nucleic Acids Research, vol. 23, no. 9, pp. 1576–1583, 1995
  37. Asymmetric induction in the Michael Initiated Ring Closure reaction
    Tetrahedron, vol. 50, no. 19, pp. 5591–5614, 1994
  38. Journal of the American Chemical Society, vol. 116, no. 12, pp. 5487–5488, 1994
  39. Journal of the American Chemical Society, vol. 116, no. 8, pp. 3635–3636, 1994
  40. Journal of Organic Chemistry, vol. 59, no. 8, pp. 2270–2272, 1994
  41. Journal of Organic Chemistry, vol. 59, no. 17, pp. 5017–5026, 1994
  42. Journal of the American Chemical Society, vol. 115, no. 4, pp. 1594–1595, 1993
  43. Journal of the American Chemical Society, vol. 114, no. 8, pp. 3071–3075, 1992
  44. Factors Affecting Regioselectivity in the Intramolecular Diyl Trapping Reaction
    Synlett, vol. 1992, no. 02, pp. 107–113, 1992
  45. Electroreductive cyclization reactions: Attempts to use 2(5h)furanones (a,ß-unsaturated butenolides). Dominance of acid-base over cyclization chemistry
    Tetrahedron, vol. 47, no. 30, pp. 383–402, 1991
  46. Stereoselectivity in intramolecular diyl trapping reactions. Model studies directed toward the phorbols.
    Tetrahedron Letters, vol. 31, no. 10, pp. 1377–1380, 1990
  47. Direct observation of intermediates involved in the intramolecular diyl trapping reaction
    Tetrahedron Letters, vol. 31, no. 9, pp. 1229–1232, 1990
  48. Electrolyte-assisted stereoselection and control of cyclization vs saturation in electroreductive cyclizations
    Tetrahedron Letters, vol. 31, no. 18, pp. 2525–2528, 1990
  49. Electroreductive cyclization reactions. Stereoselection, creation of quaternary centers in bicyclic frameworks, and a formal total synthesis of quadrone.
    Tetrahedron Letters, vol. 31, no. 4, pp. 485–488, 1990
  50. Journal of Organic Chemistry, vol. 55, no. 9, pp. 2742–2752, 1990
  51. Journal of Organic Chemistry, vol. 53, no. 15, pp. 3624–3626, 1988
  52. Journal of Organic Chemistry, vol. 53, no. 10, pp. 2287–2294, 1988
  53. Intramolecular diyl trapping reactions. Arrhenius activation parameters for extrusion of nitrogen; Rate acceleration when diyl and diylophile are linked directly to one another
    Tetrahedron Letters, vol. 29, no. 45, pp. 5711–5714, 1988
  54. Journal of Organic Chemistry, vol. 52, no. 21, pp. 4647–4661, 1987
  55. The intramolecular diyl trapping reaction. A useful tool for organic synthesis
    Chemical Reviews, vol. 86, no. 5, pp. 875–884, 1986
  56. Journal of Organic Chemistry, vol. 51, no. 23, pp. 4497–4498, 1986
  57. Journal of Organic Chemistry, vol. 50, no. 13, pp. 2400–2401, 1985
  58. Intramolecular 1,3-diyl trapping reactions. Use of a diylophile directly linked to the diyl. Preparation of bicyclic furans.
    Tetrahedron Letters, vol. 26, no. 29, pp. 3417–3420, 1985
  59. Journal of Organic Chemistry, vol. 50, no. 13, pp. 2244–2251, 1985
  60. Journal of Organic Chemistry, vol. 50, no. 20, pp. 3940–3942, 1985
  61. Journal of Organic Chemistry, vol. 50, no. 12, pp. 2202–2204, 1985
  62. Journal of the American Chemical Society, vol. 107, no. 12, pp. 3721–3722, 1985
  63. Journal of the American Chemical Society, vol. 107, no. 8, pp. 2495–2505, 1985
  64. Journal of the American Chemical Society, vol. 106, no. 1, pp. 41–46, 1984
  65. Journal of Organic Chemistry, vol. 49, no. 11, pp. 1849–1853, 1984
  66. Journal of Organic Chemistry, vol. 48, no. 24, pp. 4487–4492, 1983
  67. Journal of Organic Chemistry, vol. 48, no. 18, pp. 3139–3140, 1983
  68. Journal of the American Chemical Society, vol. 105, no. 4, pp. 928–932, 1983
  69. Journal of the American Chemical Society, vol. 105, no. 23, pp. 6976–6978, 1983
  70. Journal of Organic Chemistry, vol. 48, no. 6, pp. 803–806, 1983
  71. Some unusual reactions of molecular oxygen with bicyclic diazenes which typically serve as precursors to alkylidenecyclopenane-1,3-diyls; peroxide formation
    Tetrahedron Letters, vol. 24, no. 42, pp. 4499–4502, 1983
  72. Journal of Organic Chemistry, vol. 48, no. 19, pp. 3306–3308, 1983
  73. Electroreductive cyclization. A comparison of the electrochemical and analogous chemical (MIRC) reaction
    Tetrahedron Letters, vol. 23, no. 13, pp. 1339–1342, 1982
  74. Journal of Organic Chemistry, vol. 47, no. 2, pp. 362–364, 1982
  75. Intramolecular 1,3-diyl trapping reactions: Total synthesis of the marine natural product (?, ?)?9(12)-capnellene
    Tetrahedron Letters, vol. 22, no. 44, pp. 4389–4392, 1981
  76. Journal of the American Chemical Society, vol. 103, no. 10, pp. 2744–2749, 1981
  77. Oxidative desulfonylation. Phenyl vinyl sulfone as a ketene synthetic equivalent
    Tetrahedron Letters, vol. 21, no. 35, pp. 3339–3342, 1980
  78. MIRC (?ichael ?nitiated ?ing ?losure) Reactions Formation of Three, Five, Six and Seven Membered Rings
    Tetrahedron Letters, vol. 21, no. 27, pp. 2609–2612, 1980
  79. Facile construction of C10 modified prostaglandin precursors. diyl trapping reactions using phenyl vinyl sulfoxide and phenyl vinyl sulfone.
    Tetrahedron Letters, vol. 21, no. 23, pp. 2203–2204, 1980
  80. Carbon-13 chemical shifts in tricyclo[6.3.0.03,7] undecanes (linearly fused tricyclopentanoids)
    Tetrahedron Letters, vol. 20, no. 49, pp. 309–312, 1979
  81. A new route to linearly fused tricyclopentanoids. Diyl trapping reactions in organic synthesis.
    Tetrahedron Letters, vol. 20, no. 49, pp. 305–308, 1979
  82. Journal of the American Chemical Society, vol. 101, no. 23, pp. 7129–7130, 1979
  83. Journal of Organic Chemistry, vol. 44, no. 25, pp. 4720–4722, 1979
  84. Thermally-Induced Extrusion of Sulfur Dioxide from Allyl Alkyl Sulfones. Use of the Rearrangement for the Synthesis of Dihydrojasmone
    Synthetic Communications, vol. 9, no. 6, pp. 545–552, 1979
  85. Journal of Organic Chemistry, vol. 43, no. 14, pp. 2921–2923, 1978
  86. Journal of the American Chemical Society, vol. 100, no. 14, pp. 4607–4609, 1978
  87. Journal of the American Chemical Society, vol. 98, no. 18, pp. 5723–5725, 1976
  88. Journal of the American Chemical Society, vol. 98, no. 18, pp. 5725–5726, 1976
  89. Journal of the American Chemical Society, vol. 96, no. 14, pp. 4623–4630, 1974
  90. Journal of the American Chemical Society, vol. 96, no. 16, pp. 5143–5152, 1974
  91. Journal of the American Chemical Society, vol. 94, no. 23, pp. 8256–8258, 1972
  92. Contrasting photochemistry of cyclopentenone and cyclohexenone
    Journal of the Chemical Society, Chemical Communications, no. 11, p. 698b, 1972