Curtis Omiecinski

Personal Home Page

http://www.personal.psu.edu/faculty/c/j/cjo10/

Articles in Scholarly Journals [Incomplete List]

  1. Aryl-hydrocarbon receptor activation regulates constitutive androstane receptor levels in murine and human liver
    Hepatology, vol. 46, no. 1, pp. 209–218, 2007
  2. Regulation of the human cathepsin E gene by the constitutive androstane receptor
    Archives of Biochemistry and Biophysics, vol. 467, no. 1, pp. 132–138, 2007
  3. Gene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissues
    Toxicology and Applied Pharmacology, vol. 222, no. 1, pp. 42–56, 2007
  4. Transactivation of a DR-1 PPRE by a human constitutive androstane receptor variant expressed from internal protein translation start sites
    Nucleic Acids Research, vol. 35, no. 7, pp. 2177–2190, 2007
  5. CAR2 Displays Unique Ligand Binding and RXR  Heterodimerization Characteristics
    Drug Metabolism and Disposition, vol. 35, no. 3, pp. 428–439, 2006
  6. Relative Activation of Human Pregnane X Receptor versus Constitutive Androstane Receptor Defines Distinct Classes of CYP2B6 and CYP3A4 Inducers
    Journal of Pharmacology and Experimental Therapeutics, vol. 320, no. 1, pp. 72–80, 2006
  7. Alternative Promoters Determine Tissue-Specific Expression Profiles of the Human Microsomal Epoxide Hydrolase Gene (EPHX1)
    Molecular Pharmacology, vol. 67, no. 1, pp. 220–230, 2005
  8. Retinoid X Receptor- -Dependent Transactivation by a Naturally Occurring Structural Variant of Human Constitutive Androstane Receptor (NR1I3)
    Molecular Pharmacology, vol. 68, no. 5, pp. 1239–1253, 2005
  9. Variability in Human Sensitivity to 1,3-Butadiene: Influence of Polymorphisms in the 5'-Flanking Region of the Microsomal Epoxide Hydrolase Gene (EPHX1)
    Toxicological Sciences, vol. 85, no. 1, pp. 624–631, 2005
  10. Comparison of genomic and cDNA sequences of guinea pig CYP2B18 and rat CYP2B2: Absence of a phenobarbital-responsive enhancer module in the upstream region of theCYP2B18 gene
    Journal of Biochemical and Molecular Toxicology, vol. 18, no. 3, pp. 124–130, 2004
  11. Phenobarbital responsiveness as a uniquely sensitive indicator of hepatocyte differentiation status: requirement of dexamethasone and extracellular matrix in establishing the functional integrity of cultured primary rat hepatocytes
    Experimental Cell Research, vol. 292, no. 2, pp. 252–264, 2004
  12. Functional analysis of human microsomal epoxide hydrolase genetic variants
    Chemico-Biological Interactions, vol. 150, no. 2, pp. 149–159, 2004
  13. Alternatively spliced isoforms of the human constitutive androstane receptor
    Nucleic Acids Research, vol. 31, no. 12, pp. 3194–3207, 2003
  14. Pharmacogenetics, vol. 11, no. 8, pp. 703–708, 2001
  15. Fingerprinting of Cytochrome P450 and Microsomal Epoxide Hydrolase Gene Expression in Human Blood Cells
    Toxicological Sciences, vol. 55, no. 2, pp. 352–360, 2000
  16. Identification and Functional Characterization of Human Soluble Epoxide Hydrolase Genetic Polymorphisms
    Journal of Biological Chemistry, vol. 275, no. 37, pp. 28873–28881, 2000
  17. Epoxide hydrolases: biochemistry and molecular biology
    Chemico-Biological Interactions, vol. 129, no. 1-2, pp. 41–59, 2000
  18. A large insertion in the Shiga-like toxin 2 gene (stx2) of an Escherichia coli O157:H7 clinical isolate
    International Journal of Food Microbiology, vol. 57, no. 1-2, pp. 115–124, 2000
  19. Epoxide hydrolase — polymorphism and role in toxicology
    Toxicology Letters, vol. 112-113, no. 1-3, pp. 365–370, 2000
  20. Baculovirus vectors repress phenobarbital-mediated gene induction and stimulate cytokine expression in primary cultures of rat hepatocytes
    Gene Therapy, vol. 7, no. 15, pp. 1274–1283, 2000
  21. Phenobarbital responsiveness conferred by the 5'-flanking region of the rat CYP2B2 gene in transgenic mice
    Gene, vol. 228, no. 1-2, pp. 169–179, 1999
  22. Lack of modulation by phenobarbital of cyclic AMP levels or protein kinase A activity in rat primary hepatocytes
    Biochemical Pharmacology, vol. 58, no. 7, pp. 1109–1114, 1999
  23. Insulin-mediated modulation of cytochrome P450 gene induction profiles in primary rat hepatocyte cultures
    Journal of Biochemical and Molecular Toxicology, vol. 13, no. 1, pp. 1–9, 1999
  24. Symposium overview: the role of genetic polymorphism and repair deficiencies in environmental disease [published erratum appears in Toxicol Sci 1999 Oct;51(2):317]
    Toxicological Sciences, vol. 47, no. 2, pp. 135–143, 1999
  25. Concise review of the cytochrome P450s and their roles in toxicology
    Toxicological Sciences, vol. 48, no. 2, pp. 151–156, 1999
  26. Erratum
    Toxicological Sciences, vol. 51, no. 2, pp. 317–317, 1999
  27. Human microsomal epoxide hydrolase: 5'-flanking region genetic polymorphisms
    Carcinogenesis, vol. 19, no. 3, pp. 387–393, 1998
  28. Protein Synthesis Inhibitors Exhibit a Nonspecific Effect on Phenobarbital-inducible Cytochome P450 Gene Expression in Primary Rat Hepatocytes
    Journal of Biological Chemistry, vol. 273, no. 8, pp. 4769–4775, 1998
  29. Differential induction of cytochrome P450 gene expression by 4n-alkyl-methylenedioxybenzenes in primary rat hepatocyte cultures
    Journal of Biochemical and Molecular Toxicology, vol. 12, no. 5, pp. 253–262, 1998
  30. Effects of Chemical Inducers on Human Microsomal Epoxide Hydrolase in Primary Hepatocyte Cultures
    Biochemical Pharmacology, vol. 55, no. 7, pp. 1059–1069, 1998
  31. Human Hepatic Microsomal Epoxide Hydrolase: Comparative Analysis of Polymorphic Expression
    Archives of Biochemistry and Biophysics, vol. 337, no. 2, pp. 275–283, 1997
  32. Promoter region analysis of the rat CYP2B1 and CYP2B2 genes
    Pharmacogenetics, vol. 6, no. 4, pp. 369–374, 1996
  33. Modulation of xenobiotic-inducible cytochrome P450 gene expression by dexamethasone in primary rat hepatocytes
    Pharmacogenetics, vol. 5, no. 1, pp. 24–36, 1995
  34. A Universal Approach to the Expression of Human and Rabbit Cytochrome P450s of the 2C Subfamily inEscherichia coli
    Archives of Biochemistry and Biophysics, vol. 323, no. 1, pp. 87–96, 1995
  35. cAMP-associated Inhibition of Phenobarbital-inducible Cytochrome P450 Gene Expression in Primary Rat Hepatocyte Cultures
    Journal of Biological Chemistry, vol. 270, no. 21, pp. 12762–12773, 1995
  36. The Human Microsomal Epoxide Hydrolase Gene (EPHX1): Complete Nucleotide Sequence and Structural Characterization
    Genomics, vol. 23, no. 2, pp. 433–442, 1994
  37. Expression of Cytochrome P450s and Microsomal Epoxide Hydrolase in Primary Cultures of Human Umbilical Vein Endothelial Cells
    Toxicology and Applied Pharmacology, vol. 124, no. 1, pp. 1–9, 1994
  38. Absence of enantioselectivity in the pharmacodynamics of P450 2B induction by 5-ethyl-5-phenylhydantoin in the male rat liver or in cultured rat hepatocytes
    Journal of Biochemical Toxicology, vol. 9, no. 6, pp. 279–288, 1994
  39. Influence of Extracellular Matrix Overlay on Phenobarbital-Mediated Induction of CYP2B1, 2B2, and 3A1 Genes in Primary Adult Rat Hepatocyte Culture
    Archives of Biochemistry and Biophysics, vol. 301, no. 1, pp. 103–113, 1993
  40. Human and rabbit paraoxonases: Purification, cloning, sequencing, mapping and role of polymorphism in organophosphate detoxification
    Chemico-Biological Interactions, vol. 87, no. 1-3, pp. 35–48, 1993
  41. The molecular basis of the human serum paraoxonase activity polymorphism
    Nature Genetics, vol. 3, no. 1, Article ID ng0193-73, 3 pages, 1993
  42. Biochemistry, vol. 30, no. 42, pp. 10141–10149, 1991
  43. Selective induction of cytochrome P450 isozymes in rat liver by 4-n-alkyl-methylenedioxybenzenes
    Archives of Biochemistry and Biophysics, vol. 277, no. 1, pp. 8–16, 1990
  44. Selective expression of cytochrome P450 isozymes by 4-n-alkyl-methylenedioxybenzenes in rat lung cells
    Archives of Biochemistry and Biophysics, vol. 277, no. 1, pp. 17–25, 1990
  45. Rabbit microsomal epoxide hydrolase: Isolation and characterization of the xenobiotic metabolizing enzyme cDNA*1
    Archives of Biochemistry and Biophysics, vol. 271, no. 2, pp. 380–389, 1989
  46. Xenobiotic microsomal epoxide hydrolase: 5' sequence of the human gene
    Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, vol. 1008, no. 3, pp. 357–358, 1989
  47. Regulation of gene expression in adult rat hepatocytes cultured on a basement membrane matrix
    Journal of Cellular Physiology, vol. 134, no. 3, pp. 309–323, 1988
  48. Use of a conserved consensus oligomer in the identification of cytochrome P-450 mRNAs*1
    Biochemical and Biophysical Research Communications, vol. 149, no. 2, pp. 326–333, 1987
  49. Molecular induction by phenobarbital of a rat hepatic form of cytochrome -450: Expression of a 4-kilobase messenger RNA
    Archives of Biochemistry and Biophysics, vol. 227, no. 2, pp. 478–493, 1983
  50. Substrate and position specificity of hematin-activated monooxygenation reactions
    Biochemical Pharmacology, vol. 30, no. 20, pp. 2837–2845, 1981
  51. Drug Metabolism by the Human Fetus
    Clinical Pharmacokinetics, vol. 5, no. 4, pp. 320–339, 1980
  52. Kinetics, activation, and induction of aortic mono-oxygenases—biotransformation of benzo[a]pyrene,
    Biochemical Pharmacology, vol. 28, no. 2, pp. 305–311, 1979
  53. Stimulation by hematin of monooxygenase activity in extra-hepatic tissues from rats, rabbits and chickens
    Biochemical and Biophysical Research Communications, vol. 83, no. 3, pp. 1004–1011, 1978