Werner M. Nau

Werner M. Nau’s research interests lie in the area of photochemistry, supramolecular chemistry, and biomolecular chemistry, with emphasis on mechanistic investigation and spectroscopic measurements, including laser-flash photolysis and time-resolved fluorescence. He has developed molecular probes based on fluorescent azoalkanes, which have found applications for investigating the kinetics of host-guest complexation, diffusion of antioxidants in membranes, and intrachain collision in biopolymers. More recently, he has turned to the construction of supramolecular metalloenzyme models based on dynamic self-assembly and host-induced pKa shifts affected by macrocycles, including cyclodextrins, calixarenes, and cucurbturils. He coauthored in some recent references including “Cucurbituril encapsulation of fluorescent dyes,” “Supramolecular dye laser with cucurbit[7]uril in water,” “New insights into the mechanism of triplet radical-pair combinations. The persistent radical effect masks the distinction between in-cage and out-of-cage processes,” “Efficient fluorescence enhancement and cooperative binding of an organic dye in a supra-biomolecular host-protein assembly.”

Articles in Scholarly Journals [Incomplete List]

  1. Supramolecular Dye Laser with Cucurbit[7]uril in Water
    ChemPhysChem, vol. 8, no. 1, pp. 54–56, 2007
  2. Design of peptide substrates for nanosecond time-resolved fluorescence assays of proteases: 2,3-Diazabicyclo[2.2.2]oct-2-ene as a noninvasive fluorophore
    Analytical Biochemistry, vol. 360, no. 2, pp. 255–265, 2007
  3. Dynamically Self-Assembling Metalloenzyme Models Based on Calixarenes
    Angewandte Chemie International Edition, vol. 45, no. 44, pp. 7400–7404, 2006
  4. Nanosecond Time-Resolved Fluorescence Protease Assays
    ChemBioChem, vol. 7, no. 5, pp. 733–737, 2006
  5. Analysis of Host-Assisted Guest Protonation Exemplified forp-Sulfonatocalix[4]arene—Towards Enzyme-Mimetic pKa Shifts
    Chemistry - A European Journal, vol. 12, no. 18, pp. 4799–4807, 2006
  6. Diastereomeric Discrimination in the Lifetimes of Norrish Type II Triplet 1,4-Biradicals and Stereocontrolled Partitioning of Their Reactivity (Yang Cyclization versus Type II Fragmentation)
    Chemistry - A European Journal, vol. 12, no. 34, pp. 8744–8749, 2006
  7. Fluorescence Regeneration as a Signaling Principle for Choline and Carnitine Binding: A Refined Supramolecular Sensor System Based on a Fluorescent Azoalkane
    Advanced Functional Materials, vol. 16, no. 2, pp. 237–242, 2006
  8. Journal of the American Chemical Society, vol. 128, no. 25, pp. 8118–8119, 2006
  9. The Journal of Organic Chemistry, vol. 71, no. 5, pp. 1977–1983, 2006
  10. The Journal of Physical Chemistry B, vol. 110, no. 10, pp. 5132–5138, 2006
  11. Temperature-dependent loop formation kinetics in flexible peptides studied by time-resolved fluorescence spectroscopy
    International Journal of Photoenergy, vol. 2006, Article ID 89638, 9 pages, 2006
  12. Investigation of Polar and Stereoelectronic Effects on Pure Excited-state Hydrogen Atom Abstractions from Phenols and Alkylbenzenes†
    Photochemistry and Photobiology, vol. 82, no. 1, p. 310, 2006
  13. Ultrastable Rhodamine with Cucurbituril
    Angewandte Chemie International Edition, vol. 44, no. 24, pp. 3750–3754, 2005
  14. Taming fluorescent dyes with cucurbituril
    International Journal of Photoenergy, vol. 7, no. 3, pp. 133–141, 2005
  15. Photochemical techniques for studying the flexibility of polypeptides
    Research on Chemical Intermediates, vol. 31, no. 7, pp. 717–726, 2005
  16. Binding of inorganic cations by p-sulfonatocalix[4]arene monitored through competitive fluorophore displacement in aqueous solution
    Chemical Communications, no. 43, p. 5411, 2005
  17. The Journal of Organic Chemistry, vol. 70, no. 1, pp. 39–46, 2005
  18. The Journal of Organic Chemistry, vol. 70, no. 11, pp. 4506–4509, 2005
  19. The Journal of Organic Chemistry, vol. 70, no. 18, pp. 7439–7442, 2005
  20. The Journal of Organic Chemistry, vol. 70, no. 24, pp. 9960–9966, 2005
  21. Journal of the American Chemical Society, vol. 127, no. 41, pp. 14375–14382, 2005
  22. Journal of the American Chemical Society, vol. 127, no. 44, pp. 15575–15584, 2005
  23. Chiral discrimination in the complexation of heptakis-(2,6-di--methyl)-ß-cyclodextrin with 2,3-diazabicyclo[2.2.2]oct-2-ene derivatives
    Journal of Photochemistry and Photobiology A: Chemistry, vol. 173, no. 3, pp. 340–348, 2005
  24. Journal of the American Chemical Society, vol. 126, no. 18, pp. 5806–5816, 2004
  25. Journal of the American Chemical Society, vol. 126, no. 3, pp. 808–813, 2004
  26. Journal of the American Chemical Society, vol. 126, no. 17, pp. 5482–5492, 2004
  27. Journal of the American Chemical Society, vol. 126, no. 50, pp. 16665–16675, 2004
  28. Cucurbiturils: Molecular Nanocapsules for Time-Resolved Fluorescence-Based Assays
    IEEE Transactions on Nanobioscience, vol. 3, no. 1, pp. 39–45, 2004
  29. Intramolecular singlet?singlet energy transfer in antenna-substituted azoalkanes
    Photochemical & Photobiological Sciences, vol. 3, no. 3, p. 305, 2004
  30. Refractive index effects on the oscillator strength and radiative decay rate of 2,3-diazabicyclo[2.2.2]oct-2-ene
    Photochemical & Photobiological Sciences, vol. 3, no. 11-12, p. 1026, 2004
  31. Organic Letters, vol. 5, no. 21, pp. 3911–3914, 2003
  32. Exploiting Long-Lived Molecular Fluorescence
    CHIMIA International Journal for Chemistry, vol. 57, no. 4, pp. 161–167, 2003
  33. A Conformational Flexibility Scale for Amino Acids in Peptides
    Angewandte Chemie International Edition, vol. 42, no. 20, pp. 2269–2272, 2003