Ronald A. Ghossein
Ronald A. Ghossein received his M.D. degree from Saint Joseph University School of Medicine, Beirut, Lebanon, followed by residencies at Mallory Institute of Pathology and Tufts University School of Medicine in Boston, Ma, USA, and a fellowship at Memorial Sloan-Kettering Cancer Center (MSKCC) in New York. He is currently an Associate Attending at the Department of Pathology at MSKCC. His most important studies include a critical clinicopathologic assessment of Hurthle cell carcinomas and a genomewide appraisal of the follicular variant of papillary thyroid carcinoma (FVPTC) that revealed a pattern of chromosomal abnormalities similar to follicular adenoma/carcinoma and very different from classical papillary carcinoma supporting further consideration of the current classification of thyroid neoplasms. This led Ghossein to subclassify FVPTC into encapsulated and infiltrative forms, the latter being closer to classical papillary carcinoma while the encapsulated subgroup is closer to follicular adenoma/carcinoma in its nodal metastatic pattern. This may lead to the reclassification of encapsulated FVPTC as belonging to the follicular adenoma/carcinoma family of tumor. This will in turn directly impact on the therapy of FVPTC. Another focus of his work is a better stratification of patients with aggressive thyroid carcinoma. Toward that goal, he attempted a new definition of poorly differentiated thyroid carcinomas (PDTCs) on the basis of mitosis and necrosis and found this definition superior to architectural grade in assessing the prognosis of this rare entity. This will prevent the over- and underdiagnosis of PDTC. Finally, Dr. Ghossein and his colleagues from MSKCC (Drs. Fagin, Tuttle, and Rivera) published the first and largest histopathologic and molecular characterization of radioactive iodine-refractory positron emission tomography positive thyroid carcinomas.
Biography Updated on 3 June 2010