Janice Aldrich-Wright received her undergraduate degree from the University of Technology, Sydney, Australia in 1979 and after some years in industry went back at Macquarie University, Macquarie Park, Australia and undertook a Ph.D. degree study for which she was awarded the Cornforth Medal in 1993 for best Ph.D. degree in chemistry in Australia. She has made significant contributions to the investigation of metal complex DNA interactions. Work initiated in her laboratory at UWS demonstrated by 1H NMR that both ?- and ?-[Ru(2,9-phenMe2)2(dpq)]2+ and ?-[Ru(2,9-phenMe2)2(dppz)]2+ bind to the oligonucleotide d(GTCGAC)2 by intercalation within the minor groove. These were the first octahedral metal complexes reported to exhibit minor-groove intercalation. This finding was controversial and has influenced researchers to reinvestigate the DNA interactions of metallointercalators with a less prejudiced view about the nature and extent of intercalation. Her group has also reported that platinum-based metallointercalators have anticancer activity in many cell lines and that they differ significantly in their mode of action from anticancer platinum compounds in current clinical use. Prof. Aldrich-Wright’s publications have appeared in high-profile journals; she has over 1,000 citations to her work with an average citation rate per paper of 15.33 (higher than the chemistry average).
Biography Updated on 31 October 2012