Wenge Liu holds M.D. and Ph.D. degrees. He works as an Associate Research Professor in the Department of Biomedical Engineering at Duke University, Durham, NC, USA. Upon completion of his Doctorate degree in pharmaceutical science at the Kumamoto University, Kumamoto, Japan, in 2000, Dr. Wenge Liu joined Dr. Chilkoti Lab as a Research Assistant Professor in the Department of Bioengineering, Duke University, where he directed in vivo research for the development of drug delivery system by using thermally sensitive elastin-like polypeptide (ELPs). He developed a bioradiolabeling method to label ELP with 14C during producing ELP in E. coli. This technology is capable of in vivo tracking of ELP degradation and biodistribution (Liu et al., Journal of Controlled Release, 2006). Since 2007, Liu has been optimizing ELP as a thermally responsive drug delivery carrier to develop an injectable, degradable, and alternative modality to brachytherapy for the local delivery of radionuclides to solid tumors and has achieved promising results that demonstrate that ELP-radionuclide conjugate local depot (ELP depot) is injectable, biodegradable, and able to retain the payload (radionuclide) for one week following intratumoral administration (Liu et al., Journal of Controlled Release, 2010). Since 2009, this work has been supported by an NIH grant. The most recent results indicate that the optimized ELP depot exhibited significant tumor inhibition with minimal toxicity (Liu et al., Cancer Research, 2012).
Biography Updated on 5 January 2013