James L. Sherley

James L. Sherley is an Associate Professor of biological engineering in the Biological Engineering Division at MIT. He is also an affiliated faculty member in three MIT Centers: the Center for Environmental Health Sciences, the Biotechnology Process Engineering Center, and the Center for Cancer Research. In addition, Professor Sherley holds an adjunct appointment as an Associate Professor in the Department of Biochemistry at Meharry Medical College in Nashville, Tennessee. Professor Sherley initiated formal training in cancer research with a B.A. degree in biology from Harvard College in 1980. He matriculated to the Johns Hopkins University School of Medicine in Baltimore, Maryland, and in 1988 graduated with joint M.D./Ph.D. degrees, with an emphasis on biochemistry and molecular and cellular biology. Thereafter, as a Postdoctoral Fellow at Princeton University, Professor Sherley developed model cell systems to investigate the cellular function of the p53 cancer gene. In 1991, he established a research program in adult stem cell kinetics as a principal investigator in the Division of Medical Science at the Fox Chase Cancer Center in Philadelphia. In 1998, as the first hire into MIT's Biological Engineering Faculty as an Assistant Professor, he established his current research program in adult stem cell biological engineering. This research program has diverse applications that reflect Professor Sherley’s broad interests and expertise in tissue engineering, cell replacement therapy, aging, cancer, and environmental health science. Professor Sherley is an outspoken advocate for improved scientific disclosure in the interest of the public good.

Biography Updated on 16 March 2007

Articles in Scholarly Journals [Incomplete List]

  1. CFP and YFP, but Not GFP, Provide Stable Fluorescent Marking of Rat Hepatic Adult Stem Cells
    Journal of Biomedicine and Biotechnology, vol. 2008, Article ID 453590, 9 pages, 2008
  2. Commentary: Facing up to the Feasibility of ANT-OAR
    Stem Cell Reviews, vol. 3, no. 1, pp. 66–67, 2007
  3. Race and tenure case was not handled fairly by MIT
    Nature, vol. 448, no. 7151, Article ID 448250b, 1 pages, 2007
  4. Romancing biology: tissue and cell engineering in the new era of biological engineering
    Current Opinion in Biotechnology, vol. 17, no. 5, pp. 499–500, 2006
  5. Semiconservative quasispecies equations for polysomic genomes: The haploid case
    Journal of Theoretical Biology, 2006
  6. Biological Principles for Ex Vivo Adult Stem Cell Expansion
    Current Topics in Developmental Biology, vol. 73, pp. 141–171, 2006
  7. EMP-1 is a junctional protein in a liver stem cell line and in the liver
    Biochemical and Biophysical Research Communications, vol. 334, no. 4, pp. 996–1003, 2005
  8. Evolutionary dynamics of adult stem cells: Comparison of random and immortal-strand segregation mechanisms
    Physical Review E, vol. 71, no. 4, 2005
  9. Imperfect DNA lesion repair in the semiconservative quasispecies model: Derivation of the Hamming class equations and solution of the single-fitness peak landscape
    Physical Review E, vol. 70, no. 6, 2004
  10. Human Embryonic Stem Cell Research: No Way Around a Scientific Bottleneck
    Journal of Biomedicine and Biotechnology, vol. 2004, no. 2, pp. 71–72, 2004
  11. Embryos aren't essential to stem-cell research
    Nature, vol. 423, no. 6938, Article ID 423381a, 1 pages, 2003
  12. Clonal expansion of adult rat hepatic stem cell lines by suppression of asymmetric cell kinetics (SACK)
    Biotechnology and Bioengineering, vol. 83, no. 7, pp. 760–771, 2003
  13. Metastasis: objections to the same-gene model
    Nature, vol. 419, no. 6907, Article ID 419560a, 1 pages, 2002
  14. Asymmetric Cell Kinetics Genes: The Key to Expansion of Adult Stem Cells in Culture
    TheScientificWorldJOURNAL, vol. 2, pp. 1906–1921, 2002
  15. Asymmetric Cell Kinetics Genes: The Key to Expansion of Adult Stem Cells in Culture
    Stem Cells, vol. 20, no. 6, pp. 561–572, 2002
  16. Breaching the Kinetic Barrier to in Vitro Somatic Stem Cell Propagation
    Journal of Biomedicine and Biotechnology, vol. 1, no. 1, pp. 25–27, 2001
  17. Cellular Senescence: Ex Vivo p53-Dependent Asymmetric Cell Kinetics
    Journal of Biomedicine and Biotechnology, vol. 1, no. 1, pp. 28–37, 2001
  18. Methylation of episomal plasmids as a barrier to transient gene expression via a synthetic delivery vector
    Biomolecular Engineering, vol. 18, no. 4, pp. 185–192, 2001
  19. Comparison ofbax,waf1, and IMP dehydrogenase regulation in response to wild-type p53 expression under normal growth conditions
    Journal of Cellular Physiology, vol. 177, no. 2, pp. 364–376, 1998
  20. Expression of the Wild-Type p53 Antioncogene Induces Guanine Nucleotide-Dependent Stem Cell Division Kinetics
    Proceedings of the National Academy of Sciences, vol. 92, no. 1, pp. 136–140, 1995