Rita Casadio
Rita Casadio has a degree in physics, and after working in laboratories of biophysics in USA and Germany she was enrolled by the University of Bologna, Italy, in 1987 as an Assistant Professor of biophysics, and in 2001 as a Full Professor of biochemistry/bioinformatics at the Faculty of Physical Mathematical and Natural Sciences. She is the founder and the group leader of the Biocomputing Group, a research team working since a decade in developing tools for problem solving in computational biology. One major field of research is the application of machine learning methods to the prediction of different structural and functional features of proteins, including membrane proteins. Several applications are available as web servers for sequence analysis and structure prediction, proteome annotations, and structural bioinformatics (www.biocomp.unibo.it). The results of these works have been selected several times for presentation at the International Forum of Bioinformatics “Intelligent Systems for Molecular Biology” (ISMB). A method for the prediction of protein contact maps was scored as the best of its category in CASP nos. 4 and 5 (Asimolar, California, 2000 and 2002 ). A method for predicting the topography of outer membrane proteins based on HMM and sequence profile was acknowledged with the SGI best award at ISMB02 (Edmonton, Canada, 2002). RC with the Biocomputing Unit is active in organizing international schools on bioinformatics. She cochaired WABI 2005, and serves at the Editorial Board of BMC Bioinformatics and BioData Mining. Presently, she is the President of the Bologna International Master in Bioinformatics. She is also a member of the Board of Directors of INBB, an Italian Interuniversity Consortium, acting as a representative of the Italian Minister of MIUR; the International Society of Computational Biology (ISCB); the Italian Society of Bioinformatics; and of the National CNR-Life Science Department (under the Bioinformatics project).
Biography Updated on 19 March 2008
Personal Home Page
http://lipid.biocomp.unibo.it/casadio/
Articles in Scholarly Journals [Incomplete List]
- Terlipressin infusion induces ischemia of breast skin in a cirrothic patient with hepatorenal syndrome
Digestive and Liver Disease, vol. 40, no. 4, pp. 304–305, 2008 - Use of estimated evolutionary strength at the codon level improves the prediction of disease-related protein mutations in humans
Human Mutation, vol. 29, no. 1, pp. 198–204, 2007 - Cloning, functional identification and structural modelling of Vitis vinifera S-adenosylmethionine decarboxylase
Journal of Plant Physiology, vol. 164, no. 9, pp. 1208–1219, 2007 - Non-adiabatic quantum effects from a Standard Model time-dependent Higgs vev
Nuclear Physics B, vol. 783, no. 1-2, pp. 1–30, 2007 - Robust Determinants of Thermostability Highlighted by a Codon Frequency Index Capable of Discriminating Thermophilic from Mesophilic Genomes
Journal of Proteome Research, vol. 6, no. 7, pp. 2502–2508, 2007 - Molecular mechanism of thioredoxin regulation in photosynthetic A2B2-glyceraldehyde-3-phosphate dehydrogenase
Proceedings of the National Academy of Sciences, vol. 104, no. 26, pp. 11109–11114, 2007 - The implications of alternative splicing in the ENCODE protein complement
Proceedings of the National Academy of Sciences, vol. 104, no. 13, pp. 5495–5500, 2007 - eSLDB: eukaryotic subcellular localization database
Nucleic Acids Research, vol. 35, no. Database, pp. D208–D212, 2007 - Boundaries and the Casimir effect in noncommutative space-time
Physical Review D, vol. 76, no. 2, 2007 - Guest Editor's Introduction to the Special Section on Computational Biology and Bioinformatics (WABI) -- Part 2
IEEE/ACM Transactions on Computational Biology and Bioinformatics, vol. 4, no. 1, pp. 3–3, 2007 - Modern Physics Letters A, vol. 22, no. 5, p. 339, 2007
- New Escherichia coli outer membrane proteins identified through prediction and experimental verification
Protein Science, vol. 15, no. 4, pp. 884–889, 2006 - Moving mirrors and black hole evaporation in noncommutative space-times
Physical Review D, vol. 73, no. 4, 2006 - Guest Editor's Introduction to the Special Issue on Computational Biology and Bioinformatics -- Part 1
IEEE/ACM Transactions on Computational Biology and Bioinformatics, vol. 3, no. 4, pp. 321–322, 2006 - BaCelLo: a balanced subcellular localization predictor
Bioinformatics, vol. 22, no. 14, pp. e408–e416, 2006 - Predicting the insurgence of human genetic diseases associated to single point protein mutations with support vector machines and evolutionary information
Bioinformatics, vol. 22, no. 22, pp. 2729–2734, 2006 - K-Fold: a tool for the prediction of the protein folding kinetic order and rate
Bioinformatics, vol. 23, no. 3, pp. 385–386, 2006 - PONGO: a web server for multiple predictions of all-alpha transmembrane proteins
Nucleic Acids Research, vol. 34, no. Web Server, pp. W169–W172, 2006 - The Ectodomain of Herpes Simplex Virus Glycoprotein H Contains a Membrane -Helix with Attributes of an Internal Fusion Peptide, Positionally Conserved in the Herpesviridae Family
Journal of Virology, vol. 81, no. 5, pp. 2539–2539, 2006 - Classical dynamics and stability of collapsing thick shells of matter
Classical and Quantum Gravity, vol. 23, no. 5, pp. 1493–1506, 2006 - The method of comparison equations for cosmological perturbations
Journal of Cosmology and Astroparticle Physics, vol. 2006, no. 04, pp. 011–011, 2006 - Gravitational collapse and evolution of holographic black holes
Journal of Physics: Conference Series, vol. 33, pp. 434–439, 2006 - The WWWH of remote homolog detection: The state of the art
Briefings in Bioinformatics, vol. 8, no. 2, pp. 78–87, 2006 - Hierarchical Mechanochemical Switches in Angiostatin
ChemBioChem, vol. 7, no. 11, pp. 1774–1782, 2006 - Pressure and temperature as tools for investigating the role of individual non-covalent interactions in enzymatic reactionsSulfolobus solfataricus carboxypeptidase as a model enzyme
Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics, 2006 - Preprotein Translocase of the Outer Mitochondrial Membrane: Reconstituted Tom40 Forms a Characteristic TOM Pore
Journal of Molecular Biology, 2005 - Substrate-induced conformational changes of the mitochondrial oxoglutarate carrier: a spectroscopic and molecular modelling study
Molecular Membrane Biology, vol. 22, no. 5, pp. 443–452, 2005 - The Ectodomain of Herpes Simplex Virus Glycoprotein H Contains a Membrane -Helix with Attributes of an Internal Fusion Peptide, Positionally Conserved in the Herpesviridae Family
Journal of Virology, vol. 79, no. 5, pp. 2931–2940, 2005 - Predicting protein stability changes from sequences using support vector machines
Bioinformatics, vol. 21, no. suppl_2, pp. ii54–ii58, 2005 - I-Mutant2.0: predicting stability changes upon mutation from the protein sequence or structure
Nucleic Acids Research, vol. 33, no. Web Server, pp. W306–W310, 2005 - TRAMPLE: the transmembrane protein labelling environment
Nucleic Acids Research, vol. 33, no. Web Server, pp. W198–W201, 2005 - Second order brane cosmology with radion stabilization
Physical Review D, vol. 72, no. 2, 2005 - Protein annotation as term categorization in the gene ontology using word proximity networks
BMC Bioinformatics, vol. 6, no. Suppl 1, p. S20, 2005 - Overview of BITS2005, the Second Annual Meeting of the Italian Bioinformatics Society
BMC Bioinformatics, vol. 6, no. Suppl 4, p. S1, 2005 - A new decoding algorithm for hidden Markov models improves the prediction of the topology of all-beta membrane proteins
BMC Bioinformatics, vol. 6, no. Suppl 4, p. S12, 2005 - Histone deacetylase 1: a target of 9-hydroxystearic acid in the inhibition of cell growth in human colon cancer
The Journal of Lipid Research, vol. 46, no. 8, pp. 1596–1603, 2005 - ConSeq: the identification of functionally and structurally important residues in protein sequences
Bioinformatics, vol. 20, no. 8, pp. 1322–1324, 2004 - A neural-network-based method for predicting protein stability changes upon single point mutations
Bioinformatics, vol. 20, no. suppl_1, pp. i63–i68, 2004 - Functional Characterization of a Second Porin Isoform in Drosophila melanogaster: DMPORIN2 FORMS VOLTAGE-INDEPENDENT CATION-SELECTIVE PORES
Journal of Biological Chemistry, vol. 279, no. 24, pp. 25364–25373, 2004 - Biotechnology Progress, vol. 20, no. 3, pp. 968–974, 2004
- Isothermal and non-isothermal bioreactors in the detoxification of waste waters polluted by aromatic compounds by means of immobilised laccase from Rhus vernicifera
Journal of Molecular Catalysis B: Enzymatic, vol. 27, no. 4-6, pp. 191–206, 2004 - A novel RGDS-analog inhibits angiogenesis in vitro and in vivo
Biochemical and Biophysical Research Communications, vol. 321, no. 4, pp. 809–814, 2004 - Prediction of disulfide-bonded cysteines in proteomes with a hidden neural network
PROTEOMICS, vol. 4, no. 6, pp. 1665–1671, 2004 - The prediction of membrane protein structure and genome structural annotation
Comparative and Functional Genomics, vol. 4, no. 4, pp. 406–409, 2003 - The 4th Bologna Winter School: hot topics in structural genomics
Comparative and Functional Genomics, vol. 4, no. 4, pp. 394–396, 2003 - A neural network approach to evaluate fold recognition results
Proteins: Structure, Function, and Genetics, vol. 50, no. 4, pp. 600–608, 2003 - A Shannon entropy-based filter detects high- quality profile-profile alignments in searches for remote homologues
Proteins: Structure, Function, and Bioinformatics, vol. 54, no. 2, pp. 351–360, 2003 - MaxSubSeq: an algorithm for segment-length optimization. The case study of the transmembrane spanning segments
Bioinformatics, vol. 19, no. 4, pp. 500–505, 2003 - An ENSEMBLE machine learning approach for the prediction of all-alpha membrane proteins
Bioinformatics, vol. 19, no. 90001, pp. 205i–211, 2003 - SPEPlip: the detection of signal peptide and lipoprotein cleavage sites
Bioinformatics, vol. 19, no. 18, pp. 2498–2499, 2003 - In silico prediction of the structure of membrane proteins: Is it feasible?
Briefings in Bioinformatics, vol. 4, no. 4, pp. 341–348, 2003 - Fishing new proteins in the twilight zone of genomes: The test case of outer membrane proteins in Escherichia coli K12, Escherichia coli O157:H7, and other Gram-negative bacteria
Protein Science, vol. 12, no. 6, pp. 1158–1168, 2003 - Prediction of the disulfide-bonding state of cysteines in proteins at 88% accuracy
Protein Science, vol. 11, no. 11, pp. 2735–2739, 2002 - Substitution in the Murine Nectin1 Receptor of a Single Conserved Amino Acid at a Position Distal from the Herpes Simplex Virus gD Binding Site Confers High-Affinity Binding to gD
Journal of Virology, vol. 76, no. 11, pp. 5463–5471, 2002 - Protein structure prediction and biomolecular recognition: from protein sequence to peptidomimetic design with the human β 3 integrin
SAR and QSAR in Environmental Research, vol. 13, no. 3-4, pp. 473–486, 2002 - A 3D model of the voltage-dependent anion channel (VDAC)
FEBS Letters, vol. 520, no. 1-3, pp. 1–7, 2002 - Transglutaminases: Nature’s biological glues
Biochemical Journal, vol. 368, no. 2, p. 377, 2002 - Prediction of protein-protein interaction sites in heterocomplexes with neural networks
European Journal of Biochemistry, vol. 269, no. 5, pp. 1356–1361, 2002 - Progress in predicting inter-residue contacts of proteins with neural networks and correlated mutations
Proteins: Structure, Function, and Genetics, vol. 45, no. S5, pp. 157–162, 2002 - Prediction of coordination number and relative solvent accessibility in proteins
Proteins: Structure, Function, and Genetics, vol. 47, no. 2, pp. 142–153, 2002 - Effect of molecular confinement on internal enzyme dynamics: Frequency domain fluorometry and molecular dynamics simulation studies
Biopolymers, vol. 67, no. 2, pp. 85–95, 2002 - Characterisation of immunodominant protein encoded by the F1L gene of orf virus strains isolated in Italy
Archives of Virology, vol. 147, no. 10, pp. 1989–1995, 2002 - Structure-based computational study of the catalytic and inhibition mechanisms of urease
Journal of Biological Inorganic Chemistry, vol. 6, no. 3, pp. 300–314, 2001 - Urease immobilisation on chemically grafted nylon membranes Part 1: Isothermal characterisation
Journal of Molecular Catalysis B: Enzymatic, vol. 14, no. 1-3, pp. 15–29, 2001 - Influence of the immobilization process on the activity of ß-galactosidase bound to Nylon membranes grafted with glycidyl methacrylate Part 1. Isothermal behavior
Journal of Molecular Catalysis B: Enzymatic, vol. 16, no. 3-4, pp. 175–189, 2001 - Model of interaction of the IL-1 receptor accessory protein IL-1RAcP with the IL-1ß/IL-1RI complex
FEBS Letters, vol. 499, no. 1-2, pp. 65–68, 2001 - Prediction of disulfide connectivity in proteins
Bioinformatics, vol. 17, no. 10, pp. 957–964, 2001 - RCNPRED: prediction of the residue co-ordination numbers in proteins
Bioinformatics, vol. 17, no. 2, pp. 202–204, 2001 - Prediction of the transmembrane regions of beta-barrel membrane proteins with a neural network-based predictor
Protein Science, vol. 10, no. 4, pp. 779–787, 2001 - Discrete symmetries and localization in a brane-world
Physical Review D, vol. 64, no. 2, 2001 - Gravitational collapse of a radiating shell
Physical Review D, vol. 64, no. 10, 2001 - Nonminimally coupled scalar fields in homogeneous universes
Physical Review D, vol. 61, no. 8, 2000 - Three dimensional gravity from ISO(2,1) coset models
Physical Review D, vol. 62, no. 10, 2000 - Neural Networks Predict Protein Folding and Structure: Artificial Intelligence Faces Biomolecular Complexity
SAR and QSAR in Environmental Research, vol. 11, no. 2, pp. 149–182, 2000 - The effect of tryptophanyl substitution on folding and structure of myoglobin
European Journal of Biochemistry, vol. 267, no. 13, pp. 3937–3945, 2000 - Electromagnetic contributions to lepton g-2 in a thick brane-world
Physics Letters B, vol. 495, no. 3-4, pp. 378–383, 2000 - Predictions of protein segments with the same aminoacid sequence and different secondary structure: A benchmark for predictive methods
Proteins: Structure, Function, and Genetics, vol. 41, no. 4, pp. 535–544, 2000 - Role of evolutionary information in predicting the disulfide-bonding state of cysteine in proteins
Proteins: Structure, Function, and Genetics, vol. 36, no. 3, pp. 340–346, 1999 - Neural networks to study invariant features of protein folding
Theoretical Chemistry Accounts: Theory, Computation, and Modeling (Theoretica Chimica Acta), vol. 101, no. 1-3, pp. 21–26, 1999 - The structural basis for the regulation of tissue transglutaminase by calcium ions
European Journal of Biochemistry, vol. 262, no. 3, pp. 672–679, 1999 - Energy absorption by the dilaton waves around a rotating black hole in a binary system
Physical Review D, vol. 60, no. 10, 1999 - Microfield dynamics of black holes
Physical Review D, vol. 58, no. 4, 1998 - Perturbations in the Kerr-Newman dilatonic black hole background: Maxwell waves, the dilaton background, and gravitational lensing
Physical Review D, vol. 58, no. 4, 1998 - Hamiltonian formalism for the Oppenheimer-Snyder model
Physical Review D, vol. 58, no. 6, 1998 - Erratum to: 'Functional genetic tests of DNA mismatch repair protein activity in Saccharomyces cerevisiae' [Gene 213 (1998) 159–167]
Gene, vol. 221, no. 1, p. 169, 1998 - A high diffusion coefficient for coenzyme Q10 might be related to a folded structure
FEBS Letters, vol. 426, no. 1, pp. 77–80, 1998 - An entropy criterion to detect minimally frustrated intermediates in native proteins
Proceedings of the National Academy of Sciences, vol. 95, no. 16, pp. 9290–9294, 1998 - Conformational Changes of Neuromedin B and Delta Sleep-Inducing Peptide Induced by Their Interaction with Lipid Membranes as Revealed by Spectroscopic Techniques and Molecular Dynamics Simulation,
Archives of Biochemistry and Biophysics, vol. 349, no. 2, pp. 225–235, 1998 - The prediction of protein secondary structure with a Cascade Correlation Learning Architecture of neural networks
Neural Computing & Applications, vol. 6, no. 1, pp. 57–62, 1997 - CaATP inhibition of the MgATP-dependent proton pump (H + -ATPase) in bacterial photosynthetic membranes with a mechanism of alternative substrate inhibition
Journal of Biological Inorganic Chemistry, vol. 1, no. 4, pp. 284–291, 1996 - DCCD-sensitive proton permeability of bacterial photosynthetic membranes. Cross-reconstitution studies with purified bovine heart Fo subunits
Biochimica et Biophysica Acta (BBA) - Bioenergetics, vol. 1276, no. 1, pp. 80–86, 1996 - An ab initio study of the dioxygen binding site of hemocyanin: A comparison between CASSCF, CASPT2, and DFT approaches
International Journal of Quantum Chemistry, vol. 58, no. 1, pp. 109–119, 1996 - Inorganic Chemistry, vol. 35, no. 18, pp. 5207–5212, 1996
- The Effect of Membranes on the Conformation of Neuromedin C
Biochemical and Biophysical Research Communications, vol. 214, no. 2, pp. 663–668, 1995 - Characterization of 9-aminoacridine interaction with chromatophore membranes and modelling of the probe response to artificially induced transmembrane ?pH values
Biochimica et Biophysica Acta (BBA) - Biomembranes, vol. 1237, no. 1, pp. 23–30, 1995 - A mathematical model relating diffusion of hydrophobic ions to their adsorption on biological membranes as detected with a microdialyzer
Journal of Biological Physics, vol. 19, no. 3, pp. 211–222, 1994 - Kinetic characterization of the ATP-dependent proton pump in bacterial photosynthetic membranes: a study with the fluorescent probe 9-amino-6-chloro-2-methoxyacridine
Biochimica et Biophysica Acta (BBA) - Bioenergetics, vol. 1143, no. 2, pp. 215–222, 1993 - Evaluation of the electrical capacitance in biological membranes at different phospholipid to protein ratios
European Biophysics Journal, vol. 16, no. 4, 1988 - Calibration of the response of 9-amino acridine fluorescence to transmembrane pH differences in bacterial chromatophores
Archives of Biochemistry and Biophysics, vol. 238, no. 1, pp. 219–228, 1985 -
$$\Delta \tilde \mu _{{\rm H}^ + } $$
determination in phospholipid vesicles reconstituted with aggregated and monomeric bacteriorhodopsindetermination in phospholipid vesicles reconstituted with aggregated and monomeric bacteriorhodopsin
Biophysics of Structure and Mechanism, vol. 7, no. 4, pp. 291–291, 1981 - Biochemistry, vol. 19, no. 14, pp. 3374–3381, 1980
- Limited cooperativity in the coupling between electron flow and photosynthetic ATP synthesis A comparative study in chromatophores phosphorylating at very different rates
FEBS Letters, vol. 87, no. 2, pp. 323–328, 1978 - The behavior of 9-aminoacridine as an indicator of transmembrane pH difference in liposomes of natural bacterial phospholipids
Journal of Bioenergetics and Biomembranes, vol. 9, no. 1, pp. 17–29, 1977 - Thermodynamics and Kinetics of Photophosphorylation in Bacterial Chromatophores and Their Relation with the Transmembrane Electrochemical Potential Difference of Protons
European Journal of Biochemistry, vol. 78, no. 2, pp. 389–402, 1977 - On the Determination of the Transmembrane pH Difference in Bacterial Chromatophores using 9-Aminoacridine
European Journal of Biochemistry, vol. 47, no. 1, pp. 121–128, 1974 - Electrochemical proton gradient and phosphate potential in bacterial chromatophores
FEBS Letters, vol. 49, no. 2, pp. 203–207, 1974