Walter Stühmer

Walter Stühmer received the M.S. degree in nuclear physics and the Ph.D. degrees from the Technical University Munich, Germany, in 1975 and 1980, respectively. From 1980 to 1981, Dr. Stühmer was a Research Associate at the Department of Physiology and Biophysics of the University of Washington in Seattle, USA, and then a Visiting Senior Research Scientist in Seattle. From 1983 to 1992, he was a Scientific Collaborator and independent group leader at the MPI for Biophysical Chemistry in Göttingen. Since 1992, Dr. Stühmer is Director of the Department of Molecular Biology of Neuronal Signals at the MPI for Experimental Medicine in Göttingen. Since 1995 he is Honorary Professor at the University of Göttingen. Dr. Stühmer is recipient of the Humboldt Mutis Prize (1991) and the International Amedeo and Frances Herlitzka Prize for Physiology (1998). He was a member of the selection committee of the Alexander von Humboldt Foundation from 1999 to 2007. Dr. Stühmer was an editor of the Journal of Physiology from 1991 to 1998 and serves as an editor of the European Biophysical Journal, of Biological Research and Acta Biologica Colombiana. Dr. Stühmer was awarded the Cátedra Santiago Ramón y Cajal Lectureship (2007). He was co-organizer of the first international Ringberg meeting on Ion Channels and Cancer in 2007. He is member of the German Society for Biophysics, Physiological Society, SOBLA, Society of General Physiologists, ACAL, AACR, Associated Member of the Molecular Neurobiology Department at the University of Alicante, Spain. Dr. Stühmer´s research interests include molecular biology of ion channels, cellular signal processing, and protein interactions at cell membranes (using TIRFM and FRET methods), functional electrophysiology of ion channels during neuronal interactions and during cancerogenesis as well as structure-function relationships of native and genetically modified ion channels.

Biography Updated on 12 February 2008

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Articles in Scholarly Journals [Incomplete List]

  1. The insecticidal potential of scorpion ß-toxins
    Toxicon, vol. 49, no. 4, pp. 473–489, 2007
  2. The differential preference of scorpion a-toxins for insect or mammalian sodium channels: Implications for improved insect control
    Toxicon, vol. 49, no. 4, pp. 452–472, 2007
  3. Monoclonal Antibody Blockade of the Human Eag1 Potassium Channel Function Exerts Antitumor Activity
    Cancer Research, vol. 67, no. 15, pp. 7343–7349, 2007
  4. Re-Expression of a Developmentally Restricted Potassium Channel in Autoimmune Demyelination: Kv1.4 Is Implicated in Oligodendroglial Proliferation
    American Journal Of Pathology, vol. 171, no. 2, pp. 589–598, 2007
  5. Molecular Cancer, vol. 5, no. 1, p. 41, 2006
  6. Molecular Cancer, vol. 5, no. 1, p. 42, 2006
  7. Silencing the Activity and Proliferative Properties of the Human EagI Potassium Channel by RNA Interference
    Journal of Biological Chemistry, vol. 281, no. 19, pp. 13030–13037, 2006
  8. Calcium microdomains in regulated exocytosis
    Cell Calcium, vol. 40, no. 5-6, pp. 423–439, 2006
  9. Potassium channels as tumour markers
    FEBS Letters, vol. 580, no. 12, pp. 2850–2852, 2006
  10. Different relevance of inactivation and F468 residue in the mechanisms of hEag1 channel blockage by astemizole, imipramine and dofetilide
    FEBS Letters, vol. 580, no. 21, pp. 5059–5066, 2006
  11. Glycosylation of Eag1 (Kv10.1) Potassium Channels: INTRACELLULAR TRAFFICKING AND FUNCTIONAL CONSEQUENCES
    Journal of Biological Chemistry, vol. 280, no. 33, pp. 29506–29512, 2005
  12. International Union of Pharmacology. LIII. Nomenclature and Molecular Relationships of Voltage-Gated Potassium Channels
    Pharmacological Reviews, vol. 57, no. 4, pp. 473–508, 2005
  13. Mechanism of Block of hEag1 K+ Channels by Imipramine and Astemizole
    The Journal of General Physiology, vol. 124, no. 4, pp. 301–317, 2004
  14. C-terminal domains implicated in the functional surface expression of potassium channels
    The EMBO Journal, vol. 22, no. 3, pp. 395–403, 2003
  15. Calcium regulates exocytosis at the level of single vesicles
    Nature Neuroscience, vol. 6, no. 8, Article ID nn1087, 7 pages, 2003
  16. Tityustoxin-K(alpha) blockade of the voltage-gated potassium channel Kv1.3
    British Journal of Pharmacology, vol. 139, no. 6, Article ID 0705343, 6 pages, 2003
  17. Quantifying axial secretory-granule motion with variable-angle evanescent-field excitation
    Journal of Neuroscience Methods, vol. 119, no. 1, pp. 65–73, 2002
  18. Multiparameter evanescent-wave imaging in biological fluorescence microscopy
    IEEE Journal of Quantum Electronics, vol. 38, no. 2, pp. 142–148, 2002
  19. Ion channels in health and disease
    EMBO Reports, vol. 2, no. 7, Article ID embor373, 5 pages, 2001
  20. Super-resolution measurements with evanescent-wave fluorescence excitation using variable beam incidence
    Journal of Biomedical Optics, vol. 5, no. 1, p. 23, 2000
  21. Tracking chromaffin granules on their way through the actin cortex
    European Biophysics Journal, vol. 29, no. 2, pp. 67–89, 2000
  22. Cytoskeletal interactions determine the electrophysiological properties of human EAG potassium channels
    Pfl�gers Archiv European Journal of Physiology, vol. 441, no. 2-3, pp. 167–174, 2000
  23. Multiple stimulation-dependent processes regulate the size of the releasable pool of vesicles
    European Biophysics Journal, vol. 28, no. 2, pp. 91–101, 1999
  24. Antagonistic properties of the suramin analogue NF023 at heterologously expressed P2X receptors
    Neuropharmacology, vol. 38, no. 1, pp. 141–149, 1999
  25. Oncogenic potential of EAG K+ channels
    The EMBO Journal, vol. 18, no. 20, pp. 5540–5547, 1999
  26. Evanescent-wave microscopy: a new tool to gain insight into the control of transmitter release
    Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 354, no. 1381, pp. 307–318, 1999
  27. kappa -Conotoxin PVIIA Is a Peptide Inhibiting the Shaker K+ Channel
    Journal of Biological Chemistry, vol. 273, no. 1, pp. 33–38, 1998
  28. Cell Cycle-related Changes in the Conducting Properties of r-eag K+ Channels
    The Journal of Cell Biology, vol. 143, no. 3, pp. 767–775, 1998
  29. ATP binding site of P2X channel proteins: structural similarities with class II aminoacyl-tRNA synthetases
    FEBS Letters, vol. 434, no. 1-2, pp. 61–65, 1998
  30. Structure and Function of Voltage-Gated Ion Channels
    Naturwissenschaften, vol. 85, no. 9, pp. 437–444, 1998
  31. The last few milliseconds in the life of a secretory granule
    European Biophysics Journal, vol. 27, no. 2, pp. 83–98, 1998
  32. Molecular basis for different pore properties of potassium channels from the rat brain Kv1 gene family
    Pfl�gers Archiv European Journal of Physiology, vol. 434, no. 6, pp. 661–668, 1997
  33. Molecular characterization and pharmacological properties of the human P2X3 purinoceptor
    Molecular Brain Research, vol. 47, no. 1-2, pp. 59–66, 1997
  34. Mitosis-promoting factor-mediated suppression of a cloned delayed rectifier potassium channel expressed in Xenopus oocytes
    Proceedings of the National Academy of Sciences, vol. 94, no. 2, pp. 537–542, 1997
  35. Amino terminal-dependent gating of the potassium channel rat eag is compensated by a mutation in the S4 segment
    The Journal of Physiology, vol. 502, no. 3, pp. 537–543, 1997
  36. Calcium dependence and distribution of calcium-activated chloride channels in Xenopus oocytes
    The Journal of Physiology, vol. 502, no. 3, pp. 569–574, 1997
  37. P2X4: An ATP-activated ionotropic receptor cloned from rat brain
    Proceedings of the National Academy of Sciences, vol. 93, no. 8, pp. 3684–3688, 1996
  38. Strategy for rapid immobilization of prey by a fish-hunting marine snail
    Nature, vol. 381, no. 6578, Article ID 381148a0, 3 pages, 1996
  39. Extracellular Mg 2+ regulates activation of rat eag potassium channel
    Pfl�gers Archiv European Journal of Physiology, vol. 432, no. 2, pp. 301–312, 1996
  40. Molecular cloning and functional expression of a novel rat heart P2X purinoceptor
    FEBS Letters, vol. 388, no. 2-3, pp. 123–127, 1996
  41. Cloning and Tissue Distribution of a Novel P2X Receptor from Rat Brain
    Biochemical and Biophysical Research Communications, vol. 223, no. 2, pp. 456–460, 1996
  42. alpha-Bungarotoxin-sensitive Nicotinic Receptors on Bovine Chromaffin Cells: Molecular Cloning, Functional Expression and Alternative Splicing of the alpha7 Subunit
    European Journal of Neuroscience, vol. 7, no. 4, pp. 647–655, 1995
  43. Depletion of InsP3 stores activates a Ca2+ and K+ current by means of a phosphatase and a diffusible messenger
    Nature, vol. 364, no. 6440, Article ID 364814a0, 4 pages, 1993
  44. Ether-?-go-go encodes a voltage-gated channel permeable to K+ and Ca2+ and modulated by cAMP
    Nature, vol. 365, no. 6445, Article ID 365445a0, 3 pages, 1993
  45. Signalling mechanisms stimulus-secretion coupling in the nervous system
    Current Opinion in Neurobiology, vol. 3, no. 3, pp. 269–271, 1993
  46. The structure and function of Na+ channels
    Current Opinion in Neurobiology, vol. 2, no. 3, pp. 243–246, 1992
  47. Structural parts involved in activation and inactivation of the sodium channel
    Nature, vol. 339, no. 6226, Article ID 339597a0, 6 pages, 1989
  48. Potassium channels expressed from rat brain cDNA have delayed rectifier properties
    FEBS Letters, vol. 242, no. 1, pp. 199–206, 1988
  49. Slow sodium channel inactivation in mammalian muscle: A possible role in regulating excitability
    Muscle & Nerve, vol. 11, no. 5, pp. 502–510, 1988
  50. Patch-clamping of the inner mitochondrial membrane reveals a voltage-dependent ion channel
    Nature, vol. 330, no. 6147, Article ID 330498a0, 2 pages, 1987
  51. Single Acetylcholine Receptor Channel Currents Recorded at High Hydrostatic Pressures
    Proceedings of the National Academy of Sciences, vol. 84, no. 10, pp. 3229–3233, 1987
  52. Effects of hydrostatic pressure on membrane processes. Sodium channels, calcium channels, and exocytosis
    The Journal of General Physiology, vol. 90, no. 6, pp. 765–778, 1987
  53. Use of the Loose-Patch Voltage Clamp to Determine Endplate-Area Sodium Current Density in Myasthenia Gravis
    Annals of the New York Academy of Sciences, vol. 505, no. 1 Myasthenia Gr, pp. 761–763, 1987
  54. Distribution and Mobility of Voltage-gated Ion Channels in Skeletal Muscle
    Annals of the New York Academy of Sciences, vol. 479, no. 1 Tetrodotoxin,, pp. 377–384, 1986
  55. Mobility of voltage-dependent ion channels and lectin receptors in the sarcolemma of frog skeletal muscle
    The Journal of General Physiology, vol. 87, no. 6, pp. 955–983, 1986
  56. Pressure dependence of sodium gating currents in the squid giant axon
    European Biophysics Journal, vol. 11, no. 2, pp. 137–147, 1984
  57. Effect of glucocorticoid treatment on the excitability of rat skeletal muscle
    Pfl�gers Archiv European Journal of Physiology, vol. 395, no. 2, pp. 132–137, 1982
  58. Pressure dependence of the sodium currents of squid giant axon
    The Journal of Membrane Biology, vol. 69, no. 1, pp. 23–34, 1982
  59. Pressure dependence of the potassium currents of squid giant axon
    The Journal of Membrane Biology, vol. 69, no. 1, pp. 35–40, 1982
  60. Photobleaching through Glass Micropipettes: Sodium Channels without Lateral Mobility in the Sarcolemma of Frog Skeletal Muscle
    Proceedings of the National Academy of Sciences, vol. 79, no. 3, pp. 946–950, 1982