Neelam Sharma-Walia received her Ph.D. degree in experimental medicine and biotechnology from the Postgraduate Institute of Medical Education and Research, Chandigarh, India, in 1998. She was appointed as a Senior Demonstrator in the Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh, India, from 1998–2000. She worked as a Postdoctoral Fellow in the Northwestern University Medical School, Chicago in 2001 and in the Department of Microbiology, Molecular Genetics and Immunology at University of Kansas Medical Center from 2002–2005. She joined the Rosalind Franklin University of Medicine and Science in July, 2005 as a Research Assistant Professor. She serves as an Invited Reviewer for many reputed scientific journals and scientific research grants. Her research interest with her team is studies that focus on arachidonic acid (AA) pathway in Kaposi‘s sarcoma-associated herpes virus (KSHV) pathogenesis. Their previous studies reported the upregulation of prostaglandin pathway‘s major stress angiogenic protein cyclooxygenase-2 (COX-2) and its lipid metabolite prostaglandin E2 (PGE2) in the endothelial cells strictly displaying viral latency and Body-cavity B-cell lymphoma (BCBL) cells carrying multicopy viral genome. Their studies showed that KSHV-induced COX-2/PGE2 plays important role in KSHV pathogenesis-related events like inflammation, invasion, angiogenesis, and cell survival. Using a variety of cutting edge technologies, they are currently deciphering the role of prostaglandin pathway in KSHV episome maintenance and chromatin remodeling. Their research also focuses on the identification of the cellular and viral factors involved in the stability of COX-2 and continuous regulated secretion of PGE2 in KSHV-positive lymphoma cells.
Biography Updated on 10 June 2012