Marcel van Vugt0000-0002-3202-4678
Marcel Van Vugt obtained his Ph.D. degree from the Division of Molecular Biology at The Netherlands Cancer Institute (NKI-AvL) and the Medical Oncology Department of the University Medical Center Utrecht (UMCU) in the laboratory of Professor Dr. Rene Medema. Here, he studied the role of Polo-like kinase-1 (Plk1) during the cell cycle. His Ph.D. research project described the requirement for Plk1 to build functional mitotic spindles. In addition, his work led to the finding that Polo-like kinase-1 controls the recovery of human cancer cells after treatment with genotoxic chemotherapeutics. Following his graduation in 2005, his postdoctoral training focused on the regulation of the DNA damage checkpoint by cell-cycle kinases in the laboratory of Michael B. Yaffe at the David H. Koch Institute for Integrative Cancer Research at the Massachusetts Institute of Technology (MIT, Cambridge, USA). Currently, he serves as a Principle Investigator at the Department of Medical Oncology at the University Medical Center Groningen (University of Groningen). His research line aims at finding regulatory pathways that control the cellular responses to DNA damage. Using a combination of RNA interference, bioinformatics, biochemistry, and microscopy, he studies molecular interactions, of which the clinical implications are subsequently tested using clinically relevant models.
Biography Updated on 28 August 2011