Simon J. Morley
Simon J. Morley is a Reader in biochemistry, University of Sussex, since 2005. From 1995 to 2005, he was a Senior Research Fellow of The Wellcome Trust, in the Department of Biochemistry, University of Sussex. From 1992 to 1995, he was a Senior Research Faculty sponsored by a project grant from The Wellcome Trust, in the Department of Biochemistry, University of Sussex. In 1990–1992, he was a Postdoctoral research worker in the Laboratory of Dr. George Thomas, Friedrich Miescher-Institut, Basel, Switzerland. In 1987–1990, he was a Postdoctoral research worker under the sponsorship of Dr. Jolinda Traugh, Department of Biochemistry, University of California at Riverside, Riverside, USA, and, in 1984–1987, a Postdoctoral research worker under the sponsorship of Dr. John W. B. Hershey, Department of Biological Chemistry, School of Medicine, University of California at Davis, USA. He received his Ph.D. degree in the Department of Biochemistry, University of Cambridge, UK, under the supervision of Dr. Richard Jackson and Dr. Tim Hunt, in 1984, and the B.S. degree in the Department of Biochemistry, School of Biological Sciences, University of Sussex, in 1981.
Biography Updated on 5 November 2007
Personal Home Page
http://www.sussex.ac.uk/biochemistry/profile1880.html
Articles in Scholarly Journals [Incomplete List]
- Compartmentalisation and localisation of the translation initiation factor (eIF) 4F complex in normally growing fibroblasts
Experimental Cell Research, vol. 312, no. 15, pp. 2942–2953, 2006 - Immunohistochemical mapping of total and phosphorylated eukaryotic initiation factor 4G in rat hippocampus following global brain ischemia and reperfusion
Neuroscience, vol. 139, no. 4, pp. 1235–1248, 2006 - Functional Analysis of Individual Binding Activities of the Scaffold Protein eIF4G
Journal of Biological Chemistry, vol. 282, no. 3, pp. 1695–1708, 2006 - Specific Isoforms of Translation Initiation Factor 4GI Show Differences in Translational Activity
Molecular and Cellular Biology, vol. 26, no. 22, pp. 8448–8460, 2006 - Initiation factor modifications in the preapoptotic phase
Cell Death and Differentiation, vol. 12, no. 6, Article ID 4401591, 13 pages, 2005 - Inhibition of cap-dependent translation via phosphorylation of eIF4G by protein kinase Pak2
The EMBO Journal, vol. 24, no. 23, Article ID 7600868, 11 pages, 2005 - Shortfalls in the peptidyl-prolyl ? isomerase protein Pin1 in neurons are associated with frontotemporal dementias
Neurobiology of Disease, vol. 17, no. 2, pp. 237–249, 2004 - Rapamycin-sensitive induction of eukaryotic initiation factor 4F in regenerating mouse liver
Hepatology, vol. 40, no. 3, pp. 537–544, 2004 - Molecular Cross-talk between MEK1/2 and mTOR Signaling during Recovery of 293 Cells from Hypertonic Stress
Journal of Biological Chemistry, vol. 279, no. 44, pp. 46023–46034, 2004 - Expression of fragments of translation initiation factor eIF4GI reveals a nuclear localisation signal within the N-terminal apoptotic cleavage fragment N-FAG
Journal of Cell Science, vol. 117, no. 12, pp. 2545–2555, 2004 - Overproduction of a conserved domain of fission yeast and mammalian translation initiation factor eIF4G causes aberrant cell morphology and results in disruption of the localization of F-actin and the organization of microtubules
Genes to Cells, vol. 8, no. 2, pp. 163–178, 2003 - Phosphorylation of initiation factor 4E is resistant to SB203580 in cells expressing a drug-resistant mutant of stress-activated protein kinase 2a/p38
Cellular Signalling, 2003 - Increased levels of the translation initiation factor eIF4E in differentiating epithelial lung tumor cell lines
Differentiation, vol. 71, no. 2, pp. 126–134, 2003 - The Histone 3'-Terminal Stem-Loop-Binding Protein Enhances Translation through a Functional and Physical Interaction with Eukaryotic Initiation Factor 4G (eIF4G) and eIF3
Molecular and Cellular Biology, vol. 22, no. 22, pp. 7853–7867, 2002 - Phosphorylation of Eukaryotic Initiation Factor (eIF) 4E Is Not Required for de Novo Protein Synthesis following Recovery from Hypertonic Stress in Human Kidney Cells
Journal of Biological Chemistry, vol. 277, no. 36, pp. 32855–32859, 2002 - In Vitro Cleavage of eIF4GI but not eIF4GII by HIV-1 Protease and its Effects on Translation in the Rabbit Reticulocyte Lysate System
Journal of Molecular Biology, vol. 318, no. 1, pp. 9–20, 2002 - Paxillin Associates with Poly(A)-binding Protein 1 at the Dense Endoplasmic Reticulum and the Leading Edge of Migrating Cells
Journal of Biological Chemistry, vol. 277, no. 8, pp. 6428–6437, 2002 - Disruption of the Interaction of Mammalian Protein Synthesis Eukaryotic Initiation Factor 4B with the Poly(A)-binding Protein by Caspase- and Viral Protease-mediated Cleavages
Journal of Biological Chemistry, vol. 276, no. 26, pp. 23922–23928, 2001 - Proteasome inhibitors and immunosuppressive drugs promote the cleavage of eIF4GI and eIF4GII by caspase-8-independent mechanisms in Jurkat T cell lines
FEBS Letters, vol. 503, no. 2-3, pp. 206–212, 2001 - Phosphorylation of eukaryotic initiation factor 4E (eIF4E) at Ser209 is not required for protein synthesis in vitro and in vivo
European Journal of Biochemistry, vol. 268, no. 20, pp. 5375–5385, 2001 - Interaction of Eukaryotic Translation Initiation Factor 4G with the Nuclear Cap-Binding Complex Provides a Link between Nuclear and Cytoplasmic Functions of the m7 Guanosine Cap
Molecular and Cellular Biology, vol. 21, no. 11, pp. 3632–3641, 2001 - Truncated initiation factor eIF4G lacking an eIF4E binding site can support capped mRNA translation
The EMBO Journal, vol. 20, no. 15, pp. 4233–4242, 2001 - Activity of the Hepatitis A Virus IRES Requires Association between the Cap-Binding Translation Initiation Factor (eIF4E) and eIF4G
Journal of Virology, vol. 75, no. 17, pp. 7854–7863, 2001 - The role of 5'-leader length, secondary structure and PABP concentration on cap and poly(A) tail function during translation in Xenopus oocytes
Nucleic Acids Research, vol. 28, no. 15, pp. 2943–2953, 2000 - Differential requirements for caspase-8 activity in the mechanism of phosphorylation of eIF2a, cleavage of eIF4GI and signaling events associated with the inhibition of protein synthesis in apoptotic Jurkat T cells
FEBS Letters, vol. 477, no. 3, pp. 229–236, 2000 - Changes in integrity and association of eukaryotic protein synthesis initiation factors during apoptosis
European Journal of Biochemistry, vol. 267, no. 4, pp. 1083–1091, 2000 - Translation initiation factor modifications and the regulation of protein synthesis in apoptotic cells
Cell Death and Differentiation, vol. 7, no. 7, pp. 603–615, 2000 - Cleavage of polypeptide chain initiation factor eIF4GI during apoptosis in lymphoma cells: characterisation of an internal fragment generated by caspase-3-mediated cleavage
Cell Death and Differentiation, vol. 7, no. 7, pp. 628–636, 2000 - Translation initiation factor 4E
The International Journal of Biochemistry & Cell Biology, vol. 31, no. 1, pp. 31–35, 1999 - Cellular stress in Xenopus kidney cells enhances the phosphorylation of eukaryotic translation initiation factor (eIF)4E and the association of eIF4F with poly(A)-binding protein
Biochemical Journal, vol. 342, no. 3, p. 519, 1999 - Caspase-3 is necessary and sufficient for cleavage of protein synthesis eukaryotic initiation factor 4G during apoptosis
FEBS Letters, vol. 451, no. 3, pp. 332–336, 1999 - The Association of Initiation Factor 4F with Poly(A)-binding Protein Is Enhanced in Serum-stimulated Xenopus Kidney Cells
Journal of Biological Chemistry, vol. 274, no. 1, pp. 196–204, 1999 - Cleavage of translation initiation factor 4G (eIF4G) during anti-Fas IgM-induced apoptosis does not require signalling through the p38 mitogen-activated protein (MAP) kinase
FEBS Letters, vol. 438, no. 1-2, pp. 41–48, 1998 - Rapamycin Inhibition of the G1 to S Transition Is Mediated by Effects on Cyclin D1 mRNA and Protein Stability
Journal of Biological Chemistry, vol. 273, no. 23, pp. 14424–14429, 1998 - Involvement of Stress-activated Protein Kinase and p38/RK Mitogen-activated Protein Kinase Signaling Pathways in the Enhanced Phosphorylation of Initiation Factor 4E in NIH 3T3 Cells
Journal of Biological Chemistry, vol. 272, no. 28, pp. 17887–17893, 1997 - The proteolytic cleavage of eukaryotic initiation factor (eIF) 4G is prevented by eIF4E binding protein (PHAS-I; 4E-BP1) in the reticulocyte lysate
The EMBO Journal, vol. 16, no. 4, pp. 844–855, 1997 - Signalling through either the p38 or ERK mitogen-activated protein (MAP) kinase pathway is obligatory for phorbol ester and T cell receptor complex (TCR-CD3)-stimulated phosphorylation of initiation factor (eIF) 4E in Jurkat T cells
FEBS Letters, vol. 418, no. 3, pp. 327–332, 1997 - A Reevaluation of the Cap-binding Protein, eIF4E, as a Rate-limiting Factor for Initiation of Translation in Reticulocyte Lysate
Journal of Biological Chemistry, vol. 271, no. 15, pp. 8983–8990, 1996 - The Phosphodiesterase Inhibitor SQ 20006 Selectively Blocks Mitogen Activation of p70[IMAGE] and Transition to S Phase of the Cell Division Cycle without Affecting the Steady State Phosphorylation of eIF-4E
Journal of Biological Chemistry, vol. 270, no. 44, pp. 26698–26706, 1995 - Inhibition of Protein Synthesis by the Heme-Controlled Eif-2alpha kinase Leads to the Appearance of mRNA-Containing 48S Complexes that Contain eIF-4E but Lack Methionyl-tRNAf
European Journal of Biochemistry, vol. 228, no. 1, pp. 31–38, 1995 - Signal transduction mechanisms in the regulation of protein synthesis
Molecular Biology Reports, vol. 19, no. 3, pp. 221–231, 1994 - Stimulation of translation in 3T3-L1 cells in response to insulin and phorbol ester is directly correlated with increased phosphate labelling of initiation factor (eIF-) 4F and ribosomal protein S6
Biochimie, vol. 75, no. 11, pp. 985–989, 1993 - Increased phosphorylation of eukaryotic initiation factor 4alpha during early activation of T lymphocytes correlates with increased initiation factor 4F complex formation
European Journal of Biochemistry, vol. 218, no. 1, pp. 39–48, 1993 - Activation of p70s6k is Associated with Phosphorylation of Four Clustered Sites Displaying Ser/Thr-Pro Motifs
Proceedings of the National Academy of Sciences, vol. 89, no. 15, pp. 7282–7286, 1992 - Intracellular messengers and the control of protein synthesis
Pharmacology & Therapeutics, vol. 50, no. 3, pp. 291–319, 1991 - Relationship between radiological classification and the serological and haematological features of untreated pulmonary tuberculosis in Indonesia
Tubercle, vol. 70, no. 2, pp. 103–113, 1989 - A rabbit reticulocyte factor which stimulates protein synthesis in several mammalian cell-free systems
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, vol. 825, no. 1, pp. 57–69, 1985 - Preparation and properties of an improved cell-free protein synthesis system from mammalian liver
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, vol. 825, no. 1, pp. 45–56, 1985