Simon J. Morley

Simon J. Morley is a Reader in biochemistry, University of Sussex, since 2005. From 1995 to 2005, he was a Senior Research Fellow of The Wellcome Trust, in the Department of Biochemistry, University of Sussex. From 1992 to 1995, he was a Senior Research Faculty sponsored by a project grant from The Wellcome Trust, in the Department of Biochemistry, University of Sussex. In 1990–1992, he was a Postdoctoral research worker in the Laboratory of Dr. George Thomas, Friedrich Miescher-Institut, Basel, Switzerland. In 1987–1990, he was a Postdoctoral research worker under the sponsorship of Dr. Jolinda Traugh, Department of Biochemistry, University of California at Riverside, Riverside, USA, and, in 1984–1987, a Postdoctoral research worker under the sponsorship of Dr. John W. B. Hershey, Department of Biological Chemistry, School of Medicine, University of California at Davis, USA. He received his Ph.D. degree in the Department of Biochemistry, University of Cambridge, UK, under the supervision of Dr. Richard Jackson and Dr. Tim Hunt, in 1984, and the B.S. degree in the Department of Biochemistry, School of Biological Sciences, University of Sussex, in 1981.

Biography Updated on 5 November 2007

Personal Home Page

http://www.sussex.ac.uk/biochemistry/profile1880.html

Articles in Scholarly Journals [Incomplete List]

  1. Compartmentalisation and localisation of the translation initiation factor (eIF) 4F complex in normally growing fibroblasts
    Experimental Cell Research, vol. 312, no. 15, pp. 2942–2953, 2006
  2. Immunohistochemical mapping of total and phosphorylated eukaryotic initiation factor 4G in rat hippocampus following global brain ischemia and reperfusion
    Neuroscience, vol. 139, no. 4, pp. 1235–1248, 2006
  3. Functional Analysis of Individual Binding Activities of the Scaffold Protein eIF4G
    Journal of Biological Chemistry, vol. 282, no. 3, pp. 1695–1708, 2006
  4. Specific Isoforms of Translation Initiation Factor 4GI Show Differences in Translational Activity
    Molecular and Cellular Biology, vol. 26, no. 22, pp. 8448–8460, 2006
  5. Initiation factor modifications in the preapoptotic phase
    Cell Death and Differentiation, vol. 12, no. 6, Article ID 4401591, 13 pages, 2005
  6. Inhibition of cap-dependent translation via phosphorylation of eIF4G by protein kinase Pak2
    The EMBO Journal, vol. 24, no. 23, Article ID 7600868, 11 pages, 2005
  7. Shortfalls in the peptidyl-prolyl ? isomerase protein Pin1 in neurons are associated with frontotemporal dementias
    Neurobiology of Disease, vol. 17, no. 2, pp. 237–249, 2004
  8. Rapamycin-sensitive induction of eukaryotic initiation factor 4F in regenerating mouse liver
    Hepatology, vol. 40, no. 3, pp. 537–544, 2004
  9. Molecular Cross-talk between MEK1/2 and mTOR Signaling during Recovery of 293 Cells from Hypertonic Stress
    Journal of Biological Chemistry, vol. 279, no. 44, pp. 46023–46034, 2004
  10. Expression of fragments of translation initiation factor eIF4GI reveals a nuclear localisation signal within the N-terminal apoptotic cleavage fragment N-FAG
    Journal of Cell Science, vol. 117, no. 12, pp. 2545–2555, 2004
  11. Overproduction of a conserved domain of fission yeast and mammalian translation initiation factor eIF4G causes aberrant cell morphology and results in disruption of the localization of F-actin and the organization of microtubules
    Genes to Cells, vol. 8, no. 2, pp. 163–178, 2003
  12. Phosphorylation of initiation factor 4E is resistant to SB203580 in cells expressing a drug-resistant mutant of stress-activated protein kinase 2a/p38
    Cellular Signalling, 2003
  13. Increased levels of the translation initiation factor eIF4E in differentiating epithelial lung tumor cell lines
    Differentiation, vol. 71, no. 2, pp. 126–134, 2003
  14. The Histone 3'-Terminal Stem-Loop-Binding Protein Enhances Translation through a Functional and Physical Interaction with Eukaryotic Initiation Factor 4G (eIF4G) and eIF3
    Molecular and Cellular Biology, vol. 22, no. 22, pp. 7853–7867, 2002
  15. Phosphorylation of Eukaryotic Initiation Factor (eIF) 4E Is Not Required for de Novo Protein Synthesis following Recovery from Hypertonic Stress in Human Kidney Cells
    Journal of Biological Chemistry, vol. 277, no. 36, pp. 32855–32859, 2002
  16. In Vitro Cleavage of eIF4GI but not eIF4GII by HIV-1 Protease and its Effects on Translation in the Rabbit Reticulocyte Lysate System
    Journal of Molecular Biology, vol. 318, no. 1, pp. 9–20, 2002
  17. Paxillin Associates with Poly(A)-binding Protein 1 at the Dense Endoplasmic Reticulum and the Leading Edge of Migrating Cells
    Journal of Biological Chemistry, vol. 277, no. 8, pp. 6428–6437, 2002
  18. Disruption of the Interaction of Mammalian Protein Synthesis Eukaryotic Initiation Factor 4B with the Poly(A)-binding Protein by Caspase- and Viral Protease-mediated Cleavages
    Journal of Biological Chemistry, vol. 276, no. 26, pp. 23922–23928, 2001
  19. Proteasome inhibitors and immunosuppressive drugs promote the cleavage of eIF4GI and eIF4GII by caspase-8-independent mechanisms in Jurkat T cell lines
    FEBS Letters, vol. 503, no. 2-3, pp. 206–212, 2001
  20. Phosphorylation of eukaryotic initiation factor 4E (eIF4E) at Ser209 is not required for protein synthesis in vitro and in vivo
    European Journal of Biochemistry, vol. 268, no. 20, pp. 5375–5385, 2001
  21. Interaction of Eukaryotic Translation Initiation Factor 4G with the Nuclear Cap-Binding Complex Provides a Link between Nuclear and Cytoplasmic Functions of the m7 Guanosine Cap
    Molecular and Cellular Biology, vol. 21, no. 11, pp. 3632–3641, 2001
  22. Truncated initiation factor eIF4G lacking an eIF4E binding site can support capped mRNA translation
    The EMBO Journal, vol. 20, no. 15, pp. 4233–4242, 2001
  23. Activity of the Hepatitis A Virus IRES Requires Association between the Cap-Binding Translation Initiation Factor (eIF4E) and eIF4G
    Journal of Virology, vol. 75, no. 17, pp. 7854–7863, 2001
  24. The role of 5'-leader length, secondary structure and PABP concentration on cap and poly(A) tail function during translation in Xenopus oocytes
    Nucleic Acids Research, vol. 28, no. 15, pp. 2943–2953, 2000
  25. Differential requirements for caspase-8 activity in the mechanism of phosphorylation of eIF2a, cleavage of eIF4GI and signaling events associated with the inhibition of protein synthesis in apoptotic Jurkat T cells
    FEBS Letters, vol. 477, no. 3, pp. 229–236, 2000
  26. Changes in integrity and association of eukaryotic protein synthesis initiation factors during apoptosis
    European Journal of Biochemistry, vol. 267, no. 4, pp. 1083–1091, 2000
  27. Translation initiation factor modifications and the regulation of protein synthesis in apoptotic cells
    Cell Death and Differentiation, vol. 7, no. 7, pp. 603–615, 2000
  28. Cleavage of polypeptide chain initiation factor eIF4GI during apoptosis in lymphoma cells: characterisation of an internal fragment generated by caspase-3-mediated cleavage
    Cell Death and Differentiation, vol. 7, no. 7, pp. 628–636, 2000
  29. Translation initiation factor 4E
    The International Journal of Biochemistry & Cell Biology, vol. 31, no. 1, pp. 31–35, 1999
  30. Cellular stress in Xenopus kidney cells enhances the phosphorylation of eukaryotic translation initiation factor (eIF)4E and the association of eIF4F with poly(A)-binding protein
    Biochemical Journal, vol. 342, no. 3, p. 519, 1999
  31. Caspase-3 is necessary and sufficient for cleavage of protein synthesis eukaryotic initiation factor 4G during apoptosis
    FEBS Letters, vol. 451, no. 3, pp. 332–336, 1999
  32. The Association of Initiation Factor 4F with Poly(A)-binding Protein Is Enhanced in Serum-stimulated Xenopus Kidney Cells
    Journal of Biological Chemistry, vol. 274, no. 1, pp. 196–204, 1999
  33. Cleavage of translation initiation factor 4G (eIF4G) during anti-Fas IgM-induced apoptosis does not require signalling through the p38 mitogen-activated protein (MAP) kinase
    FEBS Letters, vol. 438, no. 1-2, pp. 41–48, 1998
  34. Rapamycin Inhibition of the G1 to S Transition Is Mediated by Effects on Cyclin D1 mRNA and Protein Stability
    Journal of Biological Chemistry, vol. 273, no. 23, pp. 14424–14429, 1998
  35. Involvement of Stress-activated Protein Kinase and p38/RK Mitogen-activated Protein Kinase Signaling Pathways in the Enhanced Phosphorylation of Initiation Factor 4E in NIH 3T3 Cells
    Journal of Biological Chemistry, vol. 272, no. 28, pp. 17887–17893, 1997
  36. The proteolytic cleavage of eukaryotic initiation factor (eIF) 4G is prevented by eIF4E binding protein (PHAS-I; 4E-BP1) in the reticulocyte lysate
    The EMBO Journal, vol. 16, no. 4, pp. 844–855, 1997
  37. Signalling through either the p38 or ERK mitogen-activated protein (MAP) kinase pathway is obligatory for phorbol ester and T cell receptor complex (TCR-CD3)-stimulated phosphorylation of initiation factor (eIF) 4E in Jurkat T cells
    FEBS Letters, vol. 418, no. 3, pp. 327–332, 1997
  38. A Reevaluation of the Cap-binding Protein, eIF4E, as a Rate-limiting Factor for Initiation of Translation in Reticulocyte Lysate
    Journal of Biological Chemistry, vol. 271, no. 15, pp. 8983–8990, 1996
  39. The Phosphodiesterase Inhibitor SQ 20006 Selectively Blocks Mitogen Activation of p70[IMAGE] and Transition to S Phase of the Cell Division Cycle without Affecting the Steady State Phosphorylation of eIF-4E
    Journal of Biological Chemistry, vol. 270, no. 44, pp. 26698–26706, 1995
  40. Inhibition of Protein Synthesis by the Heme-Controlled Eif-2alpha kinase Leads to the Appearance of mRNA-Containing 48S Complexes that Contain eIF-4E but Lack Methionyl-tRNAf
    European Journal of Biochemistry, vol. 228, no. 1, pp. 31–38, 1995
  41. Signal transduction mechanisms in the regulation of protein synthesis
    Molecular Biology Reports, vol. 19, no. 3, pp. 221–231, 1994
  42. Stimulation of translation in 3T3-L1 cells in response to insulin and phorbol ester is directly correlated with increased phosphate labelling of initiation factor (eIF-) 4F and ribosomal protein S6
    Biochimie, vol. 75, no. 11, pp. 985–989, 1993
  43. Increased phosphorylation of eukaryotic initiation factor 4alpha during early activation of T lymphocytes correlates with increased initiation factor 4F complex formation
    European Journal of Biochemistry, vol. 218, no. 1, pp. 39–48, 1993
  44. Activation of p70s6k is Associated with Phosphorylation of Four Clustered Sites Displaying Ser/Thr-Pro Motifs
    Proceedings of the National Academy of Sciences, vol. 89, no. 15, pp. 7282–7286, 1992
  45. Intracellular messengers and the control of protein synthesis
    Pharmacology & Therapeutics, vol. 50, no. 3, pp. 291–319, 1991
  46. Relationship between radiological classification and the serological and haematological features of untreated pulmonary tuberculosis in Indonesia
    Tubercle, vol. 70, no. 2, pp. 103–113, 1989
  47. A rabbit reticulocyte factor which stimulates protein synthesis in several mammalian cell-free systems
    Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, vol. 825, no. 1, pp. 57–69, 1985
  48. Preparation and properties of an improved cell-free protein synthesis system from mammalian liver
    Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, vol. 825, no. 1, pp. 45–56, 1985