Emanuel E. Strehler

Emanuel E. Strehler is a Professor of biochemistry and molecular biology at the Mayo Clinic in Rochester, Minn, USA. His principal research interests concern the molecular mechanisms of calcium regulation and calcium signaling, including calcium transport systems of the membrane and calcium sensor proteins. Dr. Strehler received his M.S. degree in 1977 and his Ph.D. degree in biochemistry and cell biology in 1981 from the Swiss Federal Institute of Technology (ETH) in Zurich, Switzerland. After postdoctoral training at Umea University in Sweden (1981, Electron Microscopy) and at Harvard Medical School (1982–1986, Molecular Biology), he was an Assistant Professor in the Laboratory of Biochemistry at the ETH Zurich (1986–1992) before joining the faculty of the Mayo Clinic in Rochester, Minn, USA. Since 2006, he also serves as Adjunct Professor in the Department of Pharmacology of the University of Saskatchewan, Saskatoon, Canada. From 2000 to 2007, he was Graduate Program Director for the Molecular Neuroscience track of the Mayo Graduate School. Dr. Strehler was a Managing Editor for Frontiers in Biosciences (2000–2003) and currently serves on the Editorial Board of the Journal of Biological Chemistry (2006–2011). Dr. Strehler’s honors include the Prize and Silver Medal for his Masters (1977) and his Ph.D. thesis (1981), an EMBO short term fellowship (1981), a Fellowship for Young Advanced Researchers from the Swiss National Science Foundation (1982–1984), the ETH-Latsis Prize from the International Latsis Foundation for his work on the molecular biology of calcium pumps (1990), and a START career development award from the Swiss NSF (1990–1993). Dr. Strehler is a member of numerous professional societies, including the American Society for Cell Biology (ASCB), the American Society for Biochemistry and Molecular Biology (ASBMB), the European Calcium Society (ECS), and the American Association for the Advancement of Science (AAAS).

Biography Updated on 13 November 2007

Personal Home Page

http://mayoresearch.mayo.edu/mayo/research/staff/strehler_ee.cfm

Articles in Scholarly Journals [Incomplete List]

  1. Plasma membrane calcium pump activity is affected by the membrane protein concentration: Evidence for the involvement of the actin cytoskeleton
    Biochimica et Biophysica Acta (BBA) - Biomembranes, vol. 1768, no. 6, pp. 1641–1649, 2007
  2. The Plasma Membrane Ca2+ Pump Isoform 4a Differs from Isoform 4b in the Mechanism of Calmodulin Binding and Activation Kinetics: IMPLICATIONS FOR Ca2+ SIGNALING
    Journal of Biological Chemistry, vol. 282, no. 35, pp. 25640–25648, 2007
  3. Rapid Downregulation of NCX and PMCA in Hippocampal Neurons Following H2O2 Oxidative Stress
    Annals of the New York Academy of Sciences, vol. 1099, no. 1, pp. 436–439, 2007
  4. Plasma Membrane Ca2+ ATPases as Dynamic Regulators of Cellular Calcium Handling
    Annals of the New York Academy of Sciences, vol. 1099, no. 1, pp. 226–236, 2007
  5. Molecular determinants for differential membrane trafficking of PMCA1 and PMCA2 in mammalian hair cells
    Journal of Cell Science, vol. 119, no. 14, pp. 2995–3007, 2006
  6. Splice-Site A Choice Targets Plasma-Membrane Ca2+-ATPase Isoform 2 to Hair Bundles
    Journal of Neuroscience, vol. 26, no. 23, pp. 6172–6180, 2006
  7. Rapid Turnover of Stereocilia Membrane Proteins: Evidence from the Trafficking and Mobility of Plasma Membrane Ca2+-ATPase 2
    Journal of Neuroscience, vol. 26, no. 23, pp. 6386–6395, 2006
  8. Glutamate-induced protease-mediated loss of plasma membrane Ca2+ pump activity in rat hippocampal neurons
    Journal of Neurochemistry, vol. 98, no. 5, pp. 1646–1656, 2006
  9. Calmodulin-like Protein Increases Filopodia-dependent Cell Motility via Up-regulation of Myosin-10
    Journal of Biological Chemistry, vol. 282, no. 5, pp. 3205–3212, 2006
  10. The Homer-1 protein Ania-3 interacts with the plasma membrane calcium pump
    Biochemical and Biophysical Research Communications, vol. 343, no. 2, pp. 630–637, 2006
  11. Changes in the expression of plasma membrane calcium extrusion systems during the maturation of hippocampal neurons
    Hippocampus, vol. 16, no. 1, pp. 20–34, 2005
  12. Ontogeny of plasma membrane Ca2+ ATPase isoforms in the neural retina of the postnatal rat
    Visual Neuroscience, vol. 22, no. 3, pp. 263–274, 2005
  13. A statistical approach to the interpretation of molecular dynamics simulations of calmodulin equilibrium dynamics
    Protein Science, vol. 14, no. 12, pp. 2955–2963, 2005
  14. Calcium Pumps of Plasma Membrane and Cell Interior
    Current Molecular Medicine, vol. 4, no. 3, pp. 323–335, 2004
  15. Dynamics of Ca2+-saturated calmodulin D129N mutant studied by multiple molecular dynamics simulations
    Protein Science, vol. 12, no. 10, pp. 2215–2229, 2003
  16. Alternative Splicing of the First Intracellular Loop of Plasma Membrane Ca2+-ATPase Isoform 2 Alters Its Membrane Targeting
    Journal of Biological Chemistry, vol. 278, no. 20, pp. 18464–18470, 2003
  17. Isoform-specific distribution of the plasma membrane Ca2+ ATPase in the rat brain
    The Journal of Comparative Neurology, vol. 467, no. 4, pp. 464–476, 2003
  18. Cell-specific expression of plasma membrane calcium ATPase isoforms in retinal neurons
    The Journal of Comparative Neurology, vol. 451, no. 1, pp. 1–21, 2002
  19. Bradykinin and ATP Accelerate Ca2+ Efflux from Rat Sensory Neurons via Protein Kinase C and the Plasma Membrane Ca2+ Pump Isoform 4
    Neuron, vol. 33, no. 1, pp. 113–122, 2002
  20. Regulation of calmodulin mRNAs in differentiating human IMR-32 neuroblastoma cells
    Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics, vol. 1600, no. 1-2, pp. 95–104, 2002
  21. Plasma Membrane Ca2+ ATPase Isoform 2b Interacts Preferentially with Na+/H+ Exchanger Regulatory Factor 2 in Apical Plasma Membranes
    Journal of Biological Chemistry, vol. 277, no. 12, pp. 10506–10511, 2002
  22. The Tumor-sensitive Calmodulin-like Protein Is a Specific Light Chain of Human Unconventional Myosin X
    Journal of Biological Chemistry, vol. 276, no. 15, pp. 12182–12189, 2001
  23. Plasma Membrane Ca2+-ATPase Isoforms 2b and 4b Interact Promiscuously and Selectively with Members of the Membrane-associated Guanylate Kinase Family of PDZ (PSD95/Dlg/ZO-1) Domain-containing Proteins
    Journal of Biological Chemistry, vol. 276, no. 24, pp. 21594–21600, 2001
  24. Differentiation induces up-regulation of plasma membrane Ca2+-ATPase and concomitant increase in Ca2+ efflux in human neuroblastoma cell line IMR-32
    Journal of Neurochemistry, vol. 76, no. 6, pp. 1756–1765, 2001
  25. Erratum
    Journal of Neuroscience Research, vol. 66, no. 4, pp. 733–735, 2001
  26. Plasma membrane calcium ATPase plays a role in reducing Ca2+-mediated cytotoxicity in PC12 cells
    Journal of Neuroscience Research, vol. 64, no. 6, pp. 661–669, 2001
  27. Human Calmodulin-like Protein Is an Epithelial-Specific Protein Regulated during Keratinocyte Differentiation
    Experimental Cell Research, vol. 267, no. 2, pp. 216–224, 2001
  28. The Promoter Region of the Human PMCA1 Gene Mediates Transcriptional Downregulation by 1,25-Dihydroxyvitamin D3
    Biochemical and Biophysical Research Communications, vol. 277, no. 3, pp. 722–728, 2000
  29. The calmodulin multigene family as a unique case of genetic redundancy: multiple levels of regulation to provide spatial and temporal control of calmodulin pools?
    Cell Calcium, vol. 28, no. 2, pp. 83–96, 2000
  30. Plasma membrane calcium ATPases as critical regulators of calcium homeostasis during neuronal cell function
    Frontiers in Bioscience, vol. 4, no. 1-3, p. d869, 1999
  31. Plasma Membrane Ca2+ ATPase Isoform 4b Binds to Membrane-associated Guanylate Kinase (MAGUK) Proteins via Their PDZ (PSD-95/Dlg/ZO-1) Domains
    Journal of Biological Chemistry, vol. 273, no. 3, pp. 1591–1595, 1998
  32. Characterization of the human CALM2 calmodulin gene and comparison of the transcriptional activity of CALM1, CALM2 and CALMS
    Cell Calcium, vol. 23, no. 5, pp. 323–338, 1998
  33. Minimum CAG repeat in the human calmodulin-1 gene 5' untranslated region is required for full expression
    Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, vol. 1398, no. 3, pp. 315–320, 1998
  34. Seizure-induced alterations of plasma membrane calcium ATPase isoforms 1, 2 and 3 mRNA and protein in rat hippocampus
    Molecular Brain Research, vol. 45, no. 2, pp. 230–238, 1997
  35. mRNA expression of the four isoforms of the human plasma membrane Ca-ATPase in the human hippocampus
    Molecular Brain Research, vol. 45, no. 1, pp. 173–176, 1997
  36. Change in plasma membrane Ca2+-ATPase splice-variant expression in response to a rise in intracellular Ca2+
    Current Biology, vol. 6, no. 12, pp. 1642–1652, 1996
  37. Primary structure of human plasma membrane Ca2+-ATPase isoform 3
    Biochimica et Biophysica Acta (BBA) - Biomembranes, vol. 1283, no. 1, pp. 10–13, 1996
  38. Plasma Membrane Calcium Pump Isoform 4a Has a Longer Calmodulin-Binding Domain Than 4b
    Journal of Biological Chemistry, vol. 271, no. 7, pp. 3714–3718, 1996
  39. Transcript distribution of plasma membrane Ca2+ pump isoforms and splice variants in the human brain
    Molecular Brain Research, vol. 28, no. 2, pp. 263–272, 1995
  40. Structure of the Human CALM1 Calmodulin Gene and Identification of two CALM1 -Related Pseudogenes CALM1P1 and CALM1P2
    European Journal of Biochemistry, vol. 225, no. 1, pp. 71–82, 1994
  41. Biochemistry, vol. 32, no. 23, pp. 6089–6094, 1993
  42. Functional analysis of the promoters of the human CaMIII calmodulin gene and of the intronless gene coding for a calmodulin-like protein
    Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, vol. 1163, no. 1, pp. 1–9, 1993
  43. Localization of the Human Bona Fide Calmodulin Genes CALM1, CALM2, and CALM3 to Chromosomes 14q24-q31, 2p21.1-p21.3, and 19q13.2-q13.3
    Genomics, vol. 16, no. 2, pp. 461–465, 1993
  44. Biochemistry, vol. 31, no. 47, pp. 11785–11792, 1992
  45. Biochemistry, vol. 31, no. 51, pp. 12826–12832, 1992
  46. Microdiversity of human-plasma-membrane calcium-pump isoform 2 generated by alternative RNA splicing in the N-terminal coding region
    European Journal of Biochemistry, vol. 205, no. 1, pp. 333–340, 1992
  47. The Molecular Basis of the Modulation of the Plasma Membrane Calcium Pump by Calmodulin
    Annals of the New York Academy of Sciences, vol. 671, no. 1 Ion-Motive AT, pp. 58–69, 1992
  48. Cloning an Escherichia coli gene encoding a protein remarkably similar to mammalian aldehyde dehydrogenases
    Gene, vol. 99, no. 1, pp. 15–23, 1991
  49. Characterization of two novel human retropseudogenes related to the calmodulin-encoding gene, CaMII
    Gene, vol. 97, no. 2, pp. 245–251, 1991
  50. Localization of two genes encoding plasma membrane Ca2+-transporting ATPases to human chromosomes 1q25?32 and 12q21?23
    Genomics, vol. 9, no. 4, pp. 629–641, 1991
  51. Recent advances in the molecular characterization of plasma membrane Ca2+ pumps
    The Journal of Membrane Biology, vol. 120, no. 1, pp. 1–15, 1991
  52. Structural organization of the human CaMIII calmodulin gene
    Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, vol. 1087, no. 2, pp. 180–189, 1990
  53. mRNAs for Plasma Membrane Calcium Pump Isoforms Differing in their Regulatory Domain are Generated by Alternative Splicing that Involves Two Internal Donor Sites in a Single Exon
    Proceedings of the National Academy of Sciences, vol. 86, no. 18, pp. 6908–6912, 1989
  54. Characterization of an intronless human calmodulin-like pseudogene
    FEBS Letters, vol. 239, no. 1, pp. 121–128, 1988
  55. Complete nucleotide and encoded amino acid sequence of a mammalian myosin heavy chain gene *1Evidence against intron-dependent evolution of the rod
    Journal of Molecular Biology, vol. 190, no. 3, pp. 291–317, 1986
  56. Sarcomeric myosin heavy chain gene family: organization and pattern of expression
    Medicine & Science in Sports & Exercise, vol. 18, no. 3, pp. 299–308, 1986
  57. Differentiation of the atrioventricular node, the atrioventricular bundle and the bundle branches in the bovine heart: An immunohistochemical and enzyme histochemical study
    The Histochemical Journal, vol. 15, no. 11, pp. 1099–1111, 1983
  58. Ultrastructural localization of M-band proteins in chicken breast muscle as revealed by combined immunocytochemistry and ultramicrotomy
    Journal of Molecular Biology, vol. 166, no. 2, pp. 141–158, 1983
  59. Differentiation of Purkinje fibres and ordinary ventricular and atrial myocytes in the bovine heart: an immuno-and enzyme histochemical study
    The Histochemical Journal, vol. 14, no. 6, pp. 929–942, 1982
  60. Ultrastructural identification of human fetal Purkinje fibres—a comparative immunocytochemical and electron microscopic study of composition and structure of myofibrillar M-regions
    Journal of Molecular and Cellular Cardiology, vol. 14, no. 8, pp. 437–449, 1982
  61. The Mr 165,000 M-protein myomesin: a specific protein of cross-striated muscle cells
    The Journal of Cell Biology, vol. 89, no. 2, pp. 185–193, 1981
  62. Biochemical and ultrastructural aspects of Mr 165,000 M-protein in cross-striated chicken muscle
    The Journal of Cell Biology, vol. 86, no. 3, pp. 775–783, 1980
  63. M-protein in chicken cardiac muscle
    Experimental Cell Research, vol. 124, no. 1, pp. 39–45, 1979
  64. Isolation and characterization of parvalbumin from chicken leg-muscle
    FEBS Letters, vol. 78, no. 1, pp. 127–133, 1977