Michael D. Sevilla

Michael D. Sevilla obtained his B.S. degree in 1963 from San Jose State College in chemistry and his Ph.D. degree in 1967 from University of Washington in Physical Chemistry. After a postdoctoral appointment at University of Washington and two years with Atomics International, he joined the faculty of Oakland University in 1970 where he rose to a Professor in 1983 and Distinguished Professor in 2005. He was Acting Associate Dean of College of Arts and Sciences, Oakland University, 1994–1996, and from 1997 to 2003, he was Chair of the Department of Chemistry. He chaired Gordon Research Conference on Radiation Chemistry in 1998. He was a member NIH Radiation Study Section, l995–1998, and has served on a variety of ad hoc study section sessions. He has been Associate Editor of Radiation Research, as well as, Vice President, 2004-2005, and President, 2005-2006, of the Radiation Research Society. His research interests have been in the area of free radicals in biomolecules especially DNA employing electron spin resonance and high energy radiation sources. His research has also focused on the use of theoretical chemistry to treat free radicals formed in biomolecules to understand their mechanisms of reaction. He has authored over 170 scientific papers including 14 reviews.

Biography Updated on 9 February 2008

Personal Home Page

http://www2.oakland.edu/chemistry/faculty.cfm?ID=4561

Articles in Scholarly Journals [Incomplete List]

  1. The Role of ps* Excited States in Electron-Induced DNA Strand Break Formation: A Time-Dependent Density Functional Theory Study
    Journal of the American Chemical Society, vol. 0, no. 0, pp. 0–0, 2008
  2. Formation of Sugar Radicals in RNA Model Systems and Oligomers via Excitation of Guanine Cation Radical
    Journal of Physical Chemistry B, vol. 0, no. 0, pp. 0–0, 2008
  3. Low-Energy Electron Attachment to 5'-Thymidine Monophosphate: Modeling Single Strand Breaks Through Dissociative Electron Attachment
    Journal of Physical Chemistry B, vol. 111, no. 19, pp. 5464–5474, 2007
  4. Sugar Radicals Formed by Photoexcitation of Guanine Cation Radical in Oligonucleotides
    Journal of Physical Chemistry B, vol. 111, no. 25, pp. 7415–7421, 2007
  5. Formation of 8-oxo-7,8-dihydroguanine-radicals in  -irradiated DNA by multiple one-electron oxidations
    Nucleic Acids Research, vol. 35, no. 7, pp. 2460–2461, 2007
  6. C5'- and C3'-sugar radicals produced via photo-excitation of one-electron oxidized adenine in 2'-deoxyadenosine and its derivatives
    Nucleic Acids Research, vol. 34, no. 5, pp. 1501–1511, 2006
  7. Photo-induced Hole Transfer from Base to Sugar in DNA: Relationship to Primary Radiation Damage
    Radiation Research, vol. 165, no. 4, p. 479, 2006
  8. Base Release in Nucleosides Induced by Low-Energy Electrons: A DFT Study
    Radiation Research, vol. 165, no. 6, p. 721, 2006
  9. Journal of Physical Chemistry B, vol. 110, no. 47, pp. 24171–24180, 2006
  10. Journal of Physical Chemistry B, vol. 110, no. 47, pp. 24181–24188, 2006
  11. Journal of Physical Chemistry B, vol. 110, no. 49, pp. 25122–25123, 2006
  12. Products of the reactions of the dry and aqueous electron with hydrated DNA: hydrogen and 5,6-dihydropyrimidines
    Radiation Physics and Chemistry, vol. 72, no. 2-3, pp. 257–264, 2005
  13. Track Structure in DNA Irradiated with Heavy Ions
    Radiation Research, vol. 163, no. 4, p. 447, 2005
  14. Sugar Radicals in DNA: Isolation of Neutral Radicals in Gamma-Irradiated DNA by Hole and Electron Scavenging
    Radiation Research, vol. 163, no. 5, p. 591, 2005
  15. UVA-visible photo-excitation of guanine radical cations produces sugar radicals in DNA and model structures
    Nucleic Acids Research, vol. 33, no. 17, pp. 5553–5564, 2005
  16. Formation of 8-oxo-7,8-dihydroguanine-radicals in  -irradiated DNA by multiple one-electron oxidations
    Nucleic Acids Research, vol. 32, no. 22, pp. 6565–6574, 2004
  17. The Formation of DNA Sugar Radicals from Photoexcitation of Guanine Cation Radicals
    Radiation Research, vol. 161, no. 5, p. 582, 2004
  18. Research Breakthrough: DNA Strandedness Controls Halouracil Radiosensitization
    Radiation Research, vol. 162, no. 6, p. 603, 2004
  19. The Journal of Physical Chemistry B, vol. 108, no. 49, pp. 19013–19019, 2004
  20. The Journal of Physical Chemistry B, vol. 108, no. 17, pp. 5472–5476, 2004
  21. Journal of the American Chemical Society, vol. 125, no. 29, pp. 8916–8920, 2003
  22. Journal of the American Chemical Society, vol. 125, no. 45, pp. 13668–13669, 2003
  23. Propyl gallate is a superoxide dismutase mimic and protects cultured lens epithelial cells from H2O2 insult
    Experimental Eye Research, vol. 76, no. 1, pp. 49–59, 2003
  24. Electron and Hole Transfer from DNA Base Radicals to Oxidized Products of Guanine in DNA
    Radiation Research, vol. 159, no. 3, p. 411, 2003
  25. Electron Spin Resonance Study of DNA Irradiated with an Argon-Ion Beam: Evidence for Formation of Sugar Phosphate Backbone Radicals
    Radiation Research, vol. 160, no. 2, p. 174, 2003
  26. The Journal of Physical Chemistry A, vol. 106, no. 8, pp. 1596–1603, 2002
  27. The Journal of Physical Chemistry B, vol. 106, no. 10, pp. 2755–2762, 2002
  28. The Journal of Physical Chemistry A, vol. 106, no. 40, pp. 9345–9351, 2002
  29. The Journal of Physical Chemistry A, vol. 106, no. 46, pp. 11248–11253, 2002
  30. The Journal of Physical Chemistry B, vol. 105, no. 8, pp. 1614–1617, 2001
  31. The Journal of Physical Chemistry B, vol. 105, no. 25, pp. 6031–6041, 2001
  32. The Journal of Physical Chemistry B, vol. 105, no. 41, pp. 10115–10123, 2001
  33. The Journal of Physical Chemistry B, vol. 104, no. 29, pp. 6942–6949, 2000
  34. The Journal of Physical Chemistry B, vol. 104, no. 44, pp. 10406–10411, 2000
  35. Reductively Activated Cleavage of DNA Mediated by o,o′-Diphenylenehalonium Compounds
    Radiation Research, vol. 154, no. 3, p. 319, 2000
  36. The Journal of Physical Chemistry B, vol. 104, no. 5, pp. 1128–1136, 2000
  37. The Journal of Physical Chemistry A, vol. 103, no. 11, pp. 1619–1626, 1999
  38. The Journal of Physical Chemistry A, vol. 103, no. 32, pp. 6351–6359, 1999
  39. Modification of the Reductive Pathway in Gamma-Irradiated DNA by Electron Scavengers: Targeting the Sugar-Phosphate Backbone
    Radiation Research, vol. 149, no. 5, p. 422, 1998
  40. Secondary radical attack on DNA nucleotides: reaction by addition to DNA bases and abstraction from sugars
    International Journal of Radiation Biology, vol. 71, no. 4, pp. 387–399, 1997
  41. The Journal of Physical Chemistry B, vol. 101, no. 8, pp. 1460–1467, 1997
  42. The Journal of Physical Chemistry A, vol. 101, no. 15, pp. 2910–2915, 1997
  43. The Journal of Physical Chemistry A, vol. 101, no. 47, pp. 8935–8941, 1997
  44. The Journal of Physical Chemistry, vol. 100, no. 10, pp. 4090–4096, 1996
  45. The Journal of Physical Chemistry, vol. 100, no. 11, pp. 4420–4423, 1996
  46. Reactions of sulphonyl peroxyl radicals with DNA and its components: hydrogen abstraction from the sugar backbone versus addition to pyrimidine double bonds
    International Journal of Radiation Biology, vol. 69, no. 1, pp. 75–87, 1996
  47. Radiation-Induced DNA Damage as a Function of Hydration. II. Base Damage from Electron-Loss Centers
    Radiation Research, vol. 145, no. 3, p. 304, 1996
  48. Electron Spin Resonance of DNA Irradiated with a Heavy-Ion Beam ( 16 O 8+ ): Evidence for Damage to the Deoxyribose Phosphate Backbone
    Radiation Research, vol. 146, no. 4, p. 361, 1996
  49. Yields of ∙ OH in Gamma-Irradiated DNA as a Function of DNA Hydration: Hole Transfer in Competition with ∙ OH Formation
    Radiation Research, vol. 145, no. 6, p. 673, 1996
  50. Elucidation of Primary Radiation Damage in DNA through Application of Ab Initio Molecular Orbital Theory
    International Journal of Radiation Biology, vol. 67, no. 6, pp. 627–645, 1995
  51. Journal of Physical Chemistry, vol. 99, no. 3, pp. 1060–1063, 1995
  52. Journal of Physical Chemistry, vol. 99, no. 11, pp. 3867–3874, 1995
  53. Journal of Physical Chemistry, vol. 99, no. 20, pp. 7993–8001, 1995
  54. Journal of Physical Chemistry, vol. 99, no. 34, pp. 13033–13037, 1995
  55. Journal of Physical Chemistry, vol. 98, no. 8, pp. 2215–2215, 1994
  56. Journal of Physical Chemistry, vol. 98, no. 41, pp. 10484–10491, 1994
  57. Influence of Oxygen on the Repair of Direct Radiation Damage to DNA by Thiols in Model Systems
    International Journal of Radiation Biology, vol. 65, no. 5, pp. 537–548, 1994
  58. ESR Detection at 77 K of the Hydroxyl Radical in the Hydration Layer of Gamma-Irradiated DNA
    Radiation Research, vol. 140, no. 1, p. 123, 1994
  59. The Influence of Hydration on the Absolute Yields of Primary Free Radicals in Gamma-Irradiated DNA at 77 K. II. Individual Radical Yields
    Radiation Research, vol. 137, no. 1, p. 2, 1994
  60. Protonation of Nucleobase Anions in Gamma-Irradiated DNA and Model Systems. Which DNA Base Is the Ultimate Sink for the Electron?
    Radiation Research, vol. 138, no. 1, p. 9, 1994
  61. The Influence of Hydration on the Absolute Yields of Primary Ionic Free Radicals in g-Irradiated DNA at 77 K: I. Total Radical Yields
    Radiation Research, vol. 135, no. 2, p. 146, 1993
  62. Journal of Physical Chemistry, vol. 97, no. 30, pp. 8092–8097, 1993
  63. Journal of Physical Chemistry, vol. 97, no. 51, pp. 13852–13859, 1993
  64. The Superoxide Dismutase Mimic TEMPOL Protects Cultured Rabbit Lens Epithelial Cells from Hydrogen Peroxide Insult
    Experimental Eye Research, vol. 56, no. 5, pp. 543–554, 1993
  65. Journal of Physical Chemistry, vol. 96, no. 2, pp. 661–668, 1992
  66. Journal of Physical Chemistry, vol. 96, no. 4, pp. 1983–1989, 1992
  67. Journal of Physical Chemistry, vol. 96, no. 24, pp. 9787–9794, 1992
  68. Journal of Agricultural and Food Chemistry, vol. 40, no. 11, pp. 2045–2051, 1992
  69. Radiation-Induced DNA Damage as a Function of Hydration: I. Release of Unaltered Bases
    Radiation Research, vol. 129, no. 3, p. 333, 1992
  70. Journal of Physical Chemistry, vol. 95, no. 8, pp. 3409–3415, 1991
  71. Journal of Physical Chemistry, vol. 95, no. 9, pp. 3676–3681, 1991
  72. Journal of Physical Chemistry, vol. 95, no. 17, pp. 6487–6493, 1991
  73. Journal of Physical Chemistry, vol. 94, no. 4, pp. 1447–1452, 1990
  74. Journal of Physical Chemistry, vol. 94, no. 18, pp. 7185–7190, 1990
  75. Journal of Physical Chemistry, vol. 93, no. 1, pp. 155–161, 1989
  76. Journal of Physical Chemistry, vol. 92, no. 13, pp. 3745–3751, 1988
  77. Thiol peroxyl radical formation from the reaction of cysteine thiyl radical with molecular oxygen: An ESR investigation
    Biochemical and Biophysical Research Communications, vol. 155, no. 1, pp. 405–410, 1988
  78. Sulfinyl radical formation from the reaction of cysteine and glutathione thiyl radicals with molecular oxygen
    Biochemical and Biophysical Research Communications, vol. 144, no. 2, pp. 1037–1042, 1987
  79. Journal of Physical Chemistry, vol. 91, no. 2, pp. 487–491, 1987
  80. Journal of Physical Chemistry, vol. 91, no. 2, pp. 492–496, 1987
  81. Radiolysis of Spin-Labeled DNA: An Electron Spin Resonance Investigation
    Radiation Research, vol. 112, no. 1, p. 21, 1987
  82. Macromolecules, vol. 20, no. 6, pp. 1222–1227, 1987
  83. Journal of Physical Chemistry, vol. 90, no. 24, pp. 6446–6451, 1986
  84. Journal of Physical Chemistry, vol. 90, no. 13, pp. 2963–2968, 1986
  85. Journal of Physical Chemistry, vol. 89, no. 12, pp. 2638–2646, 1985
  86. Journal of Physical Chemistry, vol. 89, no. 24, pp. 5251–5255, 1985
  87. Journal of Physical Chemistry, vol. 87, no. 4, pp. 634–640, 1983
  88. Journal of Physical Chemistry, vol. 87, no. 9, pp. 1648–1652, 1983
  89. An esr study of radical intermediates formed by ? - radiolysis of tripalmitin and dipalmitoyl phosphatidylethanolamine
    Journal of the American Oil Chemists’ Society, vol. 60, no. 5, pp. 950–957, 1983
  90. Reaction of the antithrombotic and antimetastatic agent, nafazatrom, with oxidizing radicals
    Biochemical and Biophysical Research Communications, vol. 115, no. 3, pp. 800–806, 1983
  91. Journal of Physical Chemistry, vol. 85, no. 8, pp. 1027–1031, 1981
  92. ESR studies of barriers to ring inversion in cyclic monocarboxylic acid radicals
    The Journal of Chemical Physics, vol. 72, no. 2, p. 1325, 1980
  93. Journal of Physical Chemistry, vol. 83, no. 10, pp. 1323–1327, 1979
  94. Journal of Physical Chemistry, vol. 83, no. 22, pp. 2887–2892, 1979
  95. Journal of Physical Chemistry, vol. 83, no. 22, pp. 2893–2897, 1979
  96. Journal of Physical Chemistry, vol. 82, no. 3, pp. 338–342, 1978
  97. Journal of Physical Chemistry, vol. 82, no. 24, pp. 2589–2594, 1978
  98. Journal of Physical Chemistry, vol. 81, no. 12, pp. 1198–1200, 1977
  99. Journal of Physical Chemistry, vol. 80, no. 4, pp. 353–358, 1976
  100. Journal of Physical Chemistry, vol. 80, no. 17, pp. 1898–1901, 1976
  101. ESR Study of the Anion Radicals of 5-Nitropyrimidines: Conversion to Iminoxy Radicals
    Radiation Research, vol. 65, no. 1, p. 29, 1976
  102. Journal of Physical Chemistry, vol. 79, no. 8, pp. 839–845, 1975
  103. Journal of Physical Chemistry, vol. 78, no. 7, pp. 696–699, 1974
  104. The Purine DNA Base Cation and Anion Radicals: An E.S.R. Study
    International Journal of Radiation Biology, vol. 25, no. 6, pp. 635–638, 1974
  105. Journal of Physical Chemistry, vol. 77, no. 25, pp. 2954–2959, 1973
  106. Journal of Physical Chemistry, vol. 76, no. 24, pp. 3571–3577, 1972
  107. Journal of Physical Chemistry, vol. 76, no. 24, pp. 3577–3582, 1972
  108. Journal of Physical Chemistry, vol. 75, no. 5, pp. 626–631, 1971