Wolfgang Neuhofer is a Heisenberg Fellow of the Deutsche Forschungsgemeinschaft. He studied medicine at the Ludwig-Maximilians-Universität München and graduated in 1999; he made the thesis of his M.D. degree in 2000 and got the Habilitation degree in 2004. Since 1995, he made research activities at the Department of Physiology, LMU München. Neuhofer worked in clinical training in internal medicine at the Department of Medicine, Inner City Campus, LMU, and became an Internist in 2010. Major research fields include the analysis of signal transduction pathways during osmotic stress, in particular the regulation of osmolyte-accumulating mechanisms and heat shock proteins by the osmosensitive transcription factor NFAT5 and the effect of S-nitrosylation of NFAT5 on its transcriptional activity. A further focus is on the role of NFAT5 in proinflammatory cytokine production. In addition to the application of common molecular biology methods, conditional knockout of NFAT in mice is being used to advance the understanding of the mechanisms promoting cell survival in the extremely hostile environment in the renal medulla.
Biography Updated on 10 May 2011