Virginia Moser

Virginia Moser is a Research Toxicologist in the Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development of the US EPA located in Research Triangle Park, North Carolina, USA. She has been at EPA since receiving her Ph.D. degree in pharmacology and toxicology at the Medical College of Virginia in 1983. Dr. Moser is a diplomate of the American Board of Toxicology, and has received several honors from US EPA, including the Scientific Achievement Award for Human Health Research for her pioneering efforts in developing the US EPA functional observational battery. As an active member of numerous scientific societies, she has held office, served on planning committees, and organized meetings. Currently, she is the President of the North Carolina Regional Chapter of the Society of Toxicology. She has several adjunct faculty positions and serves on editorial boards for five toxicology journals. She has over 105 peer-reviewed manuscripts and book chapters published or in press. Dr. Moser has been instrumental in validating and promoting the use of neurobehavioral test methods for toxicity screening, especially the functional observational battery. She helped shape the test guidelines for neurobehavioral toxicity testing, and served as Study Director for an international multilaboratory Collaborative Study on Neurobehavioral Test Methods. She has also been involved with training personnel in contract, chemical, and pharmaceutical testing laboratories in the conduct of these methods, as well as training risk assessors in the interpretation of those data. Her current research interests include neurotoxicity of pesticide mixtures, developmental neurotoxicity of brominated flame retardants, and susceptibility of the aged to environmental agents.

Biography Updated on 29 February 2008

Personal Home Page

http://toxicology.geneimprint.com/people/adjunct.php?name=Moser.V

Articles in Scholarly Journals [Incomplete List]

  1. Influence of dosing volume on the neurotoxicity of bifenthrin?
    Neurotoxicology and Teratology, vol. 29, no. 3, pp. 377–384, 2007
  2. Evaluation of developmental neurotoxicity of organotins via drinking water in rats: Dimethyl tin?
    Neurotoxicology and Teratology, vol. 29, no. 6, pp. 622–633, 2007
  3. Neurotoxicological evaluation of two disinfection by-products, bromodichloromethane and dibromoacetonitrile, in rats?
    Toxicology, vol. 230, no. 2-3, pp. 137–144, 2007
  4. The simultaneous analysis of discrete and continuous outcomes in a dose–response study: Using desirability functions?
    Regulatory Toxicology and Pharmacology, vol. 48, no. 1, pp. 51–58, 2007
  5. Comparison of Acute Neurobehavioral and Cholinesterase Inhibitory Effects of N-Methylcarbamates in Rat
    Toxicological Sciences, vol. 98, no. 2, pp. 552–560, 2007
  6. Integrating epidemiology and toxicology in neurotoxicity risk assessment
    Human & Experimental Toxicology, vol. 26, no. 4, pp. 283–293, 2007
  7. Animal models of chronic pesticide neurotoxicity
    Human & Experimental Toxicology, vol. 26, no. 4, pp. 321–332, 2007
  8. Neurotoxicological Interactions of a Five-Pesticide Mixture in Preweanling Rats
    Toxicological Sciences, vol. 92, no. 1, pp. 235–245, 2006
  9. Inhalational Exposure to Carbonyl Sulfide Produces Altered Brainstem Auditory and Somatosensory-Evoked Potentials in Fischer 344N Rats
    Toxicological Sciences, vol. 95, no. 1, pp. 118–135, 2006
  10. Evaluation of cognitive function in weanling rats: A review of methods suitable for chemical screening?
    Neurotoxicology and Teratology, vol. 28, no. 1, pp. 144–161, 2006
  11. Evaluation of developmental neurotoxicity of organotins via drinking water in rats: Monomethyl tin?
    NeuroToxicology, vol. 27, no. 3, pp. 409–420, 2006
  12. Power and Sample Size Calculations for Linear Hypotheses Associated with Mixtures of Many Components using Fixed-Ratio Ray Designs
    Environmental and Ecological Statistics, vol. 13, no. 1, pp. 11–23, 2006
  13. Ds-optimal designs for studying combinations of chemicals using multiple fixed-ratio ray experiments
    Environmetrics, vol. 16, no. 2, pp. 129–147, 2005
  14. Potential developmental toxicity of anatoxin-a, a cyanobacterial toxin
    Journal of Applied Toxicology, vol. 25, no. 6, pp. 527–534, 2005
  15. Behavioral test methods workshop
    Neurotoxicology and Teratology, vol. 27, no. 3, pp. 417–427, 2005
  16. Response to open commentary, “Validity and Utility of Geotaxis” by Motz and Alberts
    Neurotoxicology and Teratology, vol. 27, no. 4, pp. 539–540, 2005
  17. Analyses of neurobehavioral screening data: Dose?time?response modeling of continuous outcomes
    Regulatory Toxicology and Pharmacology, vol. 41, no. 3, pp. 240–255, 2005
  18. Analyses of neurobehavioral screening data: Benchmark dose estimation
    Regulatory Toxicology and Pharmacology, vol. 42, no. 2, pp. 190–201, 2005
  19. Direct Dosing of Preweaning Rodents in Toxicity Testing and Research: Deliberations of an ILSI RSI Expert Working Group
    International Journal of Toxicology, vol. 24, no. 2, pp. 87–94, 2005
  20. Neurotoxicological and Statistical Analyses of a Mixture of Five Organophosphorus Pesticides Using a Ray Design
    Toxicological Sciences, vol. 86, no. 1, pp. 101–115, 2005
  21. Neurobehavioral Effects of Chronic Dietary and Repeated High-Level Spike Exposure to Chlorpyrifos in Rats
    Toxicological Sciences, vol. 86, no. 2, pp. 375–386, 2005
  22. Neurochemical Effects of Chronic Dietary and Repeated High-Level Acute Exposure to Chlorpyrifos in Rats
    Toxicological Sciences, vol. 88, no. 1, pp. 161–171, 2005
  23. FURTHER ASSESSMENT OF AN IN VITRO SCREEN THAT MAY HELP IDENTIFY ORGANOPHOSPHORUS PESTICIDES THAT ARE MORE ACUTELY TOXIC TO THE YOUNG
    Journal of Toxicology and Environmental Health Part A, vol. 67, no. 18, pp. 1477–1489, 2004
  24. Differential profiles of cholinesterase inhibition and neurobehavioral effects in rats exposed to fenamiphos or profenofos
    Neurotoxicology and Teratology, vol. 26, no. 3, pp. 407–415, 2004
  25. Analysis of functional effects of a mixture of five pesticides using a ray design
    Environmental Toxicology and Pharmacology, vol. 18, no. 2, pp. 115–125, 2004
  26. Neurotoxicity of carbonyl sulfide in F344 rats following inhalation exposure for up to 12 weeks
    Toxicology and Applied Pharmacology, vol. 200, no. 2, pp. 131–145, 2004
  27. Neurotoxicity Produced by Dibromoacetic Acid in Drinking Water of Rats
    Toxicological Sciences, vol. 79, no. 1, pp. 112–122, 2004
  28. Detecting Interaction(s) and Assessing the Impact of Component Subsets in a Chemical Mixture Using Fixed-Ratio Mixture Ray Designs
    Journal of Agricultural, Biological & Environmental Statistics, vol. 9, no. 3, pp. 339–361, 2004
  29. Neurobehavioral evaluations of mixtures of trichloroethylene, heptachlor, and di(2-ethylhexyl)phthlate in a full-factorial design
    Toxicology, 2003
  30. LETTER TO THE EDITOR
    Toxicological Sciences, vol. 77, no. 1, pp. 183–183, 2003
  31. Neurobehavioral Assessments of Rats Perinatally Exposed to a Commercial Mixture of Polychlorinated Biphenyls
    Toxicological Sciences, vol. 68, no. 1, pp. 109–120, 2002
  32. Tissue Carboxylesterases and Chlorpyrifos Toxicity in the Developing Rat
    Human and Ecological Risk Assessment, vol. 8, no. 1, pp. 75–90, 2002
  33. Comparing cognitive and screening tests for neurotoxicity Effects of acute chlorpyrifos on visual signal detection and a neurobehavioral test battery in rats
    Neurotoxicology and Teratology, vol. 23, no. 1, pp. 33–44, 2001
  34. Neurotoxicological Outcomes of Perinatal Heptachlor Exposure in the Rat
    Toxicological Sciences, vol. 60, no. 2, pp. 315–326, 2001
  35. The Effects of Perinatal Tebuconazole Exposure on Adult Neurological, Immunological, and Reproductive Function in Rats
    Toxicological Sciences, vol. 62, no. 2, pp. 339–352, 2001
  36. Dopamine Transporter Binding in the Rat Striatum Is Increased by Gestational, Perinatal, and Adolescent Exposure to Heptachlor
    Toxicological Sciences, vol. 64, no. 2, pp. 216–223, 2001
  37. Observational Batteries in Neurotoxicity Testing
    International Journal of Toxicology, vol. 19, no. 6, pp. 407–411, 2000
  38. Rapid neurobehavioral analysis of Pfiesteria piscicida effects in juvenile and adult rats
    Neurotoxicology and Teratology, vol. 22, no. 4, pp. 533–540, 2000
  39. Dose–response and time-course of neurobehavioral changes following oral chlorpyrifos in rats of different ages
    Neurotoxicology and Teratology, vol. 22, no. 5, pp. 713–723, 2000
  40. Cognitive evaluation: is it needed in neurotoxicity screening? Symposium presented at the annual Behavioral Toxicology Society meeting, May 1999
    Neurotoxicology and Teratology, vol. 22, no. 6, pp. 785–798, 2000
  41. Gestational exposure to chlorpyrifos: dose response profiles for cholinesterase and carboxylesterase activity
    Toxicological Sciences, vol. 52, no. 1, pp. 92–100, 1999
  42. Pfiesteria Toxin and Learning Performance
    Neurotoxicology and Teratology, vol. 21, no. 3, pp. 215–221, 1999
  43. Behavioral Evaluation of the Neurotoxicity Produced by Dichloroacetic Acid in Rats
    Neurotoxicology and Teratology, vol. 21, no. 6, pp. 719–731, 1999
  44. Comparison of Aldicarb and Methamidophos Neurotoxicity at Different Ages in the Rat: Behavioral and Biochemical Parameters,
    Toxicology and Applied Pharmacology, vol. 157, no. 2, pp. 94–106, 1999
  45. Letter to the Editor
    Toxicology and Applied Pharmacology, vol. 161, no. 3, pp. 302–303, 1999
  46. Age- and Gender-Related Differences in the Time Course of Behavioral and Biochemical Effects Produced by Oral Chlorpyrifos in Rats, ,
    Toxicology and Applied Pharmacology, vol. 149, no. 1, pp. 107–119, 1998
  47. Gestational Exposure to Chlorpyrifos: Apparent Protection of the Fetus?
    Toxicology and Applied Pharmacology, vol. 152, no. 1, pp. 56–65, 1998
  48. The IPCS Collaborative Study on Neurobehavioral Screening Methods,
    Fundamental and Applied Toxicology, vol. 35, no. 2, pp. 143–151, 1997
  49. Tissue-Specific Effects of Chlorpyrifos on Carboxylesterase and Cholinesterase Activity in Adult Rats: Anin Vitroandin VivoComparison
    Fundamental and Applied Toxicology, vol. 38, no. 2, pp. 148–157, 1997
  50. The IPCS Collaborative Study on Neurobehavioral Screening Methods
    Toxicological Sciences, vol. 35, no. 2, pp. 143–151, 1997
  51. Tissue-Specific Effects of Chlorpyrifos on Carboxylesterase and Cholinesterase Activity in Adult Rats: An in Vitro and in Vivo Comparison
    Toxicological Sciences, vol. 38, no. 2, pp. 148–157, 1997
  52. The Effects of Perinatal/Juvenile Methoxychlor Exposure on Adult Rat Nervous, Immune, and Reproductive System Function
    Toxicological Sciences, vol. 40, no. 1, pp. 138–157, 1997
  53. The Relationship of Oral Chlorpyrifos Effects on Behavior, Cholinesterase Inhibition, and Muscarinic Receptor Density in Rat
    Pharmacology Biochemistry and Behavior, vol. 58, no. 1, pp. 15–23, 1997
  54. RAT STRAIN-AND GENDER-RELATED DIFFERENCES IN NEUROBEHAVIORAL SCREENING: ACUTE TRIMETHYLTIN NEUROTOXICITY
    Journal of Toxicology and Environmental Health Part A, vol. 47, no. 6, pp. 567–586, 1996
  55. Slow accumulation of acetylcholinesterase in rat brain during enzyme inhibition by repeated dosing with chlorpyrifos
    Biochemical Pharmacology, vol. 49, no. 7, pp. 955–963, 1995
  56. Comparisons of the acute effects of cholinesterase inhibitors using a neurobehavioral screening battery in rats
    Neurotoxicology and Teratology, vol. 17, no. 6, pp. 617–625, 1995
  57. Utility of a neurobehavioral screening battery for differentiating the effects of two pyrethroids, permethrin and cypermethrin
    Neurotoxicology and Teratology, vol. 15, no. 2, pp. 71–83, 1993
  58. Death of intermediolateral spinal cord neurons follows selective, complement-mediated destruction of peripheral preganglionic sympathetic terminals by acetylcholinesterase antibodies
    Neuroscience, vol. 54, no. 1, pp. 201–223, 1993
  59. Prolonged Neurobehavioral and Visual Effects of Short-Term Exposure to 3,3'-Iminodipropionitrile (IDPN) in Rats
    Fundamental and Applied Toxicology, vol. 21, no. 3, pp. 277–290, 1993
  60. Paraoxon toxicity is not potentiated by prior reduction in blood acetylcholinesterase
    Toxicology and Applied Pharmacology, vol. 117, no. 1, pp. 110–115, 1992
  61. International validation of a neurobehavioral screening battery: the IPCS/WHO collaborative study
    Toxicology Letters, vol. 64-65, pp. 217–223, 1992
  62. Comparison of subchronic neurotoxicity of 2-hydroxyethyl acrylate and acrylamide in rats*1
    Fundamental and Applied Toxicology, vol. 18, no. 3, pp. 343–352, 1992
  63. Investigations of amitraz neurotoxicity in rats *1IV. Assessment of toxicity syndrome using a functional observational battery
    Fundamental and Applied Toxicology, vol. 17, no. 1, pp. 7–16, 1991
  64. Interlaboratory comparison of motor activity experiments: Implications for neurotoxicological assessments
    Neurotoxicology and Teratology, vol. 13, no. 6, pp. 599–609, 1991
  65. Rat strain and stock comparisons using a functional observational battery: Baseline values and effects of amitraz*1, *2
    Toxicology and Applied Pharmacology, vol. 108, no. 2, pp. 267–283, 1991
  66. Approaches for assessing the validity of a functional observational battery
    Neurotoxicology and Teratology, vol. 12, no. 5, pp. 483–488, 1990
  67. Neurobehavioral effects of triadimefon, a triazole fungicide, in male and female rats
    Neurotoxicology and Teratology, vol. 11, no. 3, pp. 285–293, 1989
  68. Investigations of amitraz neurotoxicity in rats *1III. Effects on motor activity and inhibition of monoamine oxidase
    Fundamental and Applied Toxicology, vol. 12, no. 1, pp. 12–22, 1989
  69. Comparison of chlordimeform and carbaryl using a functional observational battery*1
    Fundamental and Applied Toxicology, vol. 11, no. 2, pp. 189–206, 1988
  70. An ?2-adrenergic mode of action of chlordimeform on rat visual function*1
    Toxicology and Applied Pharmacology, vol. 92, no. 3, pp. 402–418, 1988
  71. Cholinergic involvement in the action of formetanate on operant behavior in rats,
    Pharmacology Biochemistry and Behavior, vol. 26, no. 1, pp. 119–121, 1987
  72. Investigations of amitraz neurotoxicity in rats *1I. Effects on operant performance
    Fundamental and Applied Toxicology, vol. 9, no. 1, pp. 131–139, 1987
  73. Investigations of amitraz neurotoxicity in rats *1II. Effects on visual evoked potentials
    Fundamental and Applied Toxicology, vol. 9, no. 1, pp. 140–153, 1987
  74. Yohimbine attenuates the delayed lethality induced in mice by amitraz, a formamidine pesticide
    Toxicology Letters, vol. 28, no. 2-3, pp. 99–104, 1985
  75. Effects of toluene, halothane and ethanol vapor on fixed-ratio performance in mice
    Pharmacology Biochemistry and Behavior, vol. 22, no. 5, pp. 797–802, 1985
  76. Monoamine oxidase inhibition cannot account for changes in visual evoked potentials produced by chlordimeform
    Neuropharmacology, vol. 24, no. 9, pp. 853–860, 1985
  77. Effects of xylene isomers on operant responding and motor performance in mice*1
    Toxicology and Applied Pharmacology, vol. 80, no. 2, pp. 293–298, 1985
  78. Acute motor and lethal effects of inhaled toluene, 1,1,1-trichloroethane, halothane, and ethanol in mice: Effects of exposure duration*1
    Toxicology and Applied Pharmacology, vol. 77, no. 2, pp. 285–291, 1985
  79. Concurrent measurement of solvent vapor concentrations and effects on operant behavior using a dynamic exposure system
    Journal of Pharmacological Methods, vol. 8, no. 4, pp. 299–309, 1982