Graziano Pesole is a Full Professor of molecular biology in the University of Bari. He has since long carried out research activity in the fields of bioinformatics, comparative genomics, and molecular evolution. In particular, his interests are computational approaches for the identification of regulatory elements in noncoding genome regions, alternative splicing, and functional analysis of untranslated regions of eukaryotic mRNAs. He has developed a specialized database (UTRdb/UTRsite), largely used by the scientific community, collecting mRNA untranslated sequences and related regulatory motifs involved in the posttranscriptional regulation of gene expression. He has also developed analysis software and several algorithms largely used by the scientific community and available also through web browsers. Within his studies on molecular evolution, he has contributed to the development of new analysis methodologies and has carried out several studies on the evolution of mitochondrial genome at the intraspecies level, in order to clarify some aspects of the origin of modern man, and at the interspecies one to reconstruct mammal phylogeny and to study the evolutionary dynamics of the mitochondrial genome of Tunicata. He leads an interdisciplinary research group including molecular biologists, computer scientists, and mathematicians. He coordinated research units in several research projects funded by national (MIUR, CNR, Telethon, AIRC) and international (EU, NIH) agencies, and has filed an international patent for the selection of primers for RNA fingerprinting. He is a member of the editorial board of international journals (GENE, BMC Bioinformatics, BMC Genomics, Computational Biology and Chemistry, Briefings in Bioinformatics), author of over 120 papers published in international journals, and coauthor of books on bioinformatics and genomics published by italian (Zanichelli, Gnocchi) and international (Wiley) editors.
Biography Updated on 30 October 2007