Arthur J. L. Cooper holds a Ph.D. degree, serves as a professor, and studies transglutaminases, enzymes that catalyze covalent modifications of protein substrates. Aberrant transglutaminase activity is thought to contribute to neurodegenerative diseases. Selective transglutaminase inhibitors may, therefore, be clinically useful. He also studies the role of cysteine S-conjugate b-lyases, a type of enzyme involved in the bioactivation, or toxification, of endogenous and exogenous electrophiles. Such studies may be useful in devising methods to minimize the harmful effects of certain drugs.
Biography Updated on 29 August 2012