Debanjan Biswas

United States Pharmacopeia, USA 0000-0001-5375-5667

Debanjan Biswas R&D, Monograph Development US Pharmacopeial Convention 12601 Twinbrook Parkway Rockville, Maryland 20852-1790, USA E-mail: dyb@usp.org ________________________________________ RESEARCH EXPERIENCE SUMMARY ? Development of new synthetic protocols for the preparation of primary amine diazeniumdiolates as potential HNO-releasing prodrugs for the treatment of congestive heart failure. ? Synthesis, analytical characterization, and structure activity relationship (SAR) study of N-diazeniumdiolated amidines as potential NO donors. ? Synthesis and biological assay for glutathione activated small molecule NO-donors as hybrid PARP inhibitors. ? Preparation of highly efficacious ?-Aminobutyric Acid (GABA) analogs by one-pot allylboration of aromatic, fluoro-aromatic and aliphatic nitriles. ? Multistep asymmetric organic synthesis of chiral Vigabatrin analogs. ? Screening of neuro-active compounds for potent GABAergic drugs using Patch-clamp techniques. ________________________________________ SYNTHETIC & ANALYTICAL SKILLS Synthesis and purification of air/moisture sensitive organic compounds, macro and micro scale multi-step synthesis, multi-probe NMR, preparative and analytical HPLC, UV-VIS, FT-IR, distillation, crystallization, polarimetric analysis, patch-clamp analysis with perfusion system controller. ________________________________________ PUBLICATIONS 1. J. Org. Chem. 2012, 77, 108504-10810. 2. Chem. Commun. 2012, 48, 5931-5933. 3. Heterocycles, 2011, 82, 1423-1433. 4. Chem. Commun. 2010, 46, 5799-5801. 5. Tetrahedron Lett. 2010, 51, 332-336. 6. J. Fluorine Chem. 2009, 130, 204-215. 7. Org. Lett. 2007, 9, 3025-3027. 8. Org. Lett. 2006, 8, 3877-3879. 9. Chem. Comm. 2005, 15, 1988-1989. 10. Org. Lett. 2004, 6, 481-484.

Biography Updated on 23 June 2013

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