Karl Drlica is a Professor of microbiology and molecular genetics and a member of the Public Health Research Institute at the University of Medicine and Dentistry of New Jersey. He received the Ph.D. degree in molecular biology from the University of California, Berkeley, Calif, USA, and carried out postdoctoral studies at the University of California, Davis, and Princeton University. His early work focused on DNA topoisomerases and bacterial chromosome structure. More recently, the work has turned to the study of fluoroquinolone mechanism and resistance, particularly with Mycobacterium tuberculosis. This work led to the mutant selection window hypothesis, which has spawned new dosing strategies for restricting the emergence of resistance for pathogens in general. His work is described in more than 160 research papers and book chapters. He is also the author of Understanding DNA & Gene Cloning: A Guide for the Curious and Double-Edged Sword: The Promises and Risks of the Genetic Revolution. A new book on antibiotic resistance is in preparation.
Biography Updated on 6 September 2009