Research interests are focused to the regulatory mechanisms of blood pressure and vascular function in rats and mice using various animal experimental models such as spontaneous hypertension, borderline hypertension, L-NAME-induced hypertension, stress-induced hypertension, STZ-induced diabetes and experimental hypertriglyceridemia. Special attention is paid to the role of endothelium-derived relaxing factors, mainly nitric oxide, in regulation of cardiovascular function and structure. The effect of various pharmacological and natural substances on vascular and cardiac function has been investigated. Current research is focused to the role of chronic social stress in development of endothelial dysfunction in rats with various genetic predisposition to hypertension, age- and sex-related differences in vascular adaptation to stress, role of endothelium-derived contracting factors in modulation of vascular function as well as to prevention and treatment of endothelial dysfunction in rats with borderline and fully developed hypertension. Results were published in more than 70 peer-reviewed papers, which were cited more that 500-times.
Biography Updated on 23 June 2013