Marìa A. Blasco

Articles in Scholarly Journals [Incomplete List]

  1. Cellular Senescence in Cancer and Aging
    Cell, vol. 130, no. 2, pp. 223–233, 2007
  2. A G-Quadruplex Ligand with 10000-Fold Selectivity over Duplex DNA
    Journal of the American Chemical Society, vol. 129, no. 6, pp. 1502–1503, 2007
  3. Delayed ageing through damage protection by the Arf/p53 pathway
    Nature, vol. 448, no. 7151, Article ID nature05949, 4 pages, 2007
  4. Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres
    Nature Genetics, vol. 39, no. 2, Article ID ng1952, 7 pages, 2007
  5. The epigenetic regulation of mammalian telomeres
    Nature Reviews Genetics, vol. 8, no. 4, Article ID nrg2047, 10 pages, 2007
  6. Spreading of mammalian DNA-damage response factors studied by ChIP-chip at damaged telomeres
    The EMBO Journal, vol. 26, no. 11, Article ID 7601719, 11 pages, 2007
  7. High-throughput telomere length quantification by FISH and its application to human population studies
    Proceedings of the National Academy of Sciences, vol. 104, no. 13, pp. 5300–5305, 2007
  8. Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis
    Genes & Development, vol. 21, no. 2, pp. 206–220, 2007
  9. Genetic Analysis of Myc and Telomerase Interactions In Vivo
    Molecular and Cellular Biology, vol. 26, no. 16, pp. 6130–6138, 2006
  10. Mice Deficient in Telomerase Activity Develop Hypertension Because of an Excess of Endothelin Production
    Circulation, vol. 114, no. 4, pp. 309–317, 2006
  11. Expression of mTert in primary murine cells links the growth-promoting effects of telomerase to transforming growth factor-ß signaling
    Oncogene, vol. 25, no. 31, Article ID 1209465, 9 pages, 2006
  12. Increased p53 activity does not accelerate telomere-driven ageing
    EMBO reports, Article ID 7400667, 2006
  13. DNA methyltransferases control telomere length and telomere recombination in mammalian cells
    Nature Cell Biology, vol. 8, no. 4, Article ID ncb1386, 8 pages, 2006
  14. Telomeres and telomerase in Alzheimer’s disease: Epiphenomena or a new focus for therapeutic strategy?
    Alzheimer's and Dementia, vol. 2, no. 3, pp. 164–168, 2006
  15. Novel roles for telomerase in aging
    Mechanisms of Ageing and Development, vol. 127, no. 6, pp. 579–583, 2006
  16. Telomerase regulation and stem cell behaviour
    Current Opinion in Cell Biology, vol. 18, no. 3, pp. 254–260, 2006
  17. Telomere length predicts embryo fragmentation after in vitro fertilization in women?Toward a telomere theory of reproductive aging in women
    American Journal of Obstetrics and Gynecology, vol. 192, no. 4, pp. 1256–1260, 2005
  18. Porphyrin Derivatives for Telomere Binding and Telomerase Inhibition
    ChemBioChem, vol. 6, no. 1, pp. 123–132, 2005
  19. Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin
    Nature Cell Biology, vol. 7, no. 4, Article ID ncb1235, 8 pages, 2005
  20. Antagonistic effects of telomerase on cancer and aging in K5-mTert transgenic mice
    Oncogene, vol. 24, no. 13, Article ID 1208413, 14 pages, 2005
  21. Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging
    The EMBO Journal, vol. 24, no. 6, Article ID 7600598, 8 pages, 2005
  22. XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer
    Nature Genetics, vol. 37, no. 10, Article ID ng1633, 8 pages, 2005
  23. Telomeres and human disease: ageing, cancer and beyond
    Nature Reviews Genetics, vol. 6, no. 8, Article ID nrg1656, 11 pages, 2005
  24. The telomerase RNA component Terc is required for the tumour-promoting effects of Tert overexpression
    EMBO reports, vol. 6, no. 3, Article ID 7400359, 6 pages, 2005
  25. Effectors of mammalian telomere dysfunction: a comparative transcriptome analysis using mouse models
    Carcinogenesis, vol. 26, no. 9, pp. 1613–1626, 2005
  26. Postreplicative Joining of DNA Double-Strand Breaks Causes Genomic Instability in DNA-PKcs-Deficient Mouse Embryonic Fibroblasts
    Cancer Research, vol. 65, no. 22, pp. 10223–10232, 2005
  27. Effects of Telomerase and Telomere Length on Epidermal Stem Cell Behavior
    Science, vol. 309, no. 5738, pp. 1253–1256, 2005
  28. Posterior Sloping Angle of the Capital Femoral Physis
    Journal of Pediatric Orthopaedics, vol. 25, no. 4, pp. 445–449, 2005
  29. Constitutive Expression of Tert in Thymocytes Leads to Increased Incidence and Dissemination of T-Cell Lymphoma in Lck-Tert Mice
    Molecular and Cellular Biology, vol. 24, no. 10, pp. 4275–4293, 2004
  30. Functional Interaction between Poly(ADP-Ribose) Polymerase 2 (PARP-2) and TRF2: PARP Activity Negatively Regulates TRF2
    Molecular and Cellular Biology, vol. 24, no. 4, pp. 1595–1607, 2004
  31. Role of Human Ku86 in Telomere Length Maintenance and Telomere Capping
    Cancer Research, vol. 64, no. 20, pp. 7271–7278, 2004
  32. Telomere dynamics in Fancg-deficient mouse and human cells
    Blood, vol. 104, no. 13, pp. 3927–3935, 2004
  33. Telomere shortening and chromosomal instability abrogates proliferation of adult but not embryonic neural stem cells
    Development, vol. 131, no. 16, pp. 4059–4070, 2004
  34. Repair of DNA Broken Ends is Similar in Embryonic Fibroblasts with and without Telomerase
    Radiation Research, vol. 162, no. 2, p. 136, 2004
  35. Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs
    The Journal of Cell Biology, vol. 167, no. 4, pp. 627–638, 2004
  36. Telomere epigenetics: a higher-order control of telomere length in mammalian cells
    Carcinogenesis, vol. 25, no. 7, pp. 1083–1087, 2004
  37. Irregular telomeres impair meiotic synapsis and recombination in mice
    Proceedings of the National Academy of Sciences, vol. 101, no. 17, pp. 6496–6501, 2004
  38. Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice
    EMBO reports, vol. 5, no. 5, Article ID 7400127, 6 pages, 2004
  39. Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases
    Nature Genetics, vol. 36, no. 1, Article ID ng1278, 5 pages, 2004
  40. Telomerase deficiency impairs differentiation of mesenchymal stem cells
    Experimental Cell Research, vol. 294, no. 1, pp. 1–8, 2004
  41. Long-term molecular and cellular stability of human neural stem cell lines
    Experimental Cell Research, vol. 294, no. 2, pp. 559–570, 2004
  42. Telomere Maintenance Requires the RAD51D Recombination/Repair Protein
    Cell, vol. 117, no. 3, pp. 337–347, 2004
  43. Telomeres in cancer and aging: lessons from the mouse
    Cancer Letters, vol. 194, no. 2, pp. 183–188, 2003
  44. Shortened telomeres join to DNA breaks interfering with their correct repair
    Experimental Cell Research, vol. 287, no. 2, pp. 282–288, 2003
  45. Telomeres and cancer: a tale with many endings
    Current Opinion in Genetics & Development, vol. 13, no. 1, pp. 70–76, 2003
  46. Evolving views of telomerase and cancer
    Trends in Cell Biology, vol. 13, no. 6, pp. 289–294, 2003
  47. Porphyrin–aminoquinoline conjugates as telomerase inhibitors
    Organic & Biomolecular Chemistry, vol. 1, no. 6, pp. 921–927, 2003
  48. Massive Telomere Loss Is an Early Event of DNA Damage-induced Apoptosis
    Journal of Biological Chemistry, vol. 278, no. 2, pp. 836–842, 2003
  49. Oxidative Stress Contributes to Arsenic-induced Telomere Attrition, Chromosome Instability, and Apoptosis
    Journal of Biological Chemistry, vol. 278, no. 34, pp. 31998–32004, 2003
  50. Mammalian telomeres and telomerase: why they matter for cancer and aging
    European Journal of Cell Biology, vol. 82, no. 9, pp. 441–446, 2003
  51. Role of Mammalian Rad54 in Telomere Length Maintenance
    Molecular and Cellular Biology, vol. 23, no. 16, pp. 5572–5580, 2003
  52. The RNA Subunit of Telomerase Is Encoded by Marek's Disease Virus
    Journal of Virology, vol. 77, no. 10, pp. 5985–5996, 2003
  53. Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation
    The EMBO Journal, vol. 22, no. 1, pp. 131–139, 2003
  54. Telomere shortening impairs organ regeneration by inhibiting cell cycle re-entry of a subpopulation of cells
    The EMBO Journal, vol. 22, no. 15, pp. 4003–4013, 2003
  55. Breaks at telomeres and TRF2-independent end fusions in Fanconi anemia
    Human Molecular Genetics, vol. 11, no. 4, pp. 439–444, 2002
  56. Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis
    The FASEB Journal, vol. 16, no. 9, pp. 935–942, 2002
  57. Cooperation between p53 Mutation and High Telomerase Transgenic Expression in Spontaneous Cancer Development
    Molecular and Cellular Biology, vol. 22, no. 20, pp. 7291–7301, 2002
  58. Long-term repopulating ability of telomerase-deficient murine hematopoietic stem cells
    Blood, vol. 99, no. 8, pp. 2767–2775, 2002
  59. Requirement of functional telomeres for metaphase chromosome alignments and integrity of meiotic spindles
    EMBO Reports, vol. 3, no. 3, pp. 230–234, 2002
  60. Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres
    The EMBO Journal, vol. 21, no. 9, pp. 2207–2219, 2002
  61. Functional interaction between DNA-PKcs and telomerase in telomere length maintenance
    The EMBO Journal, vol. 21, no. 22, Article ID 7594812, 12 pages, 2002
  62. 'Super p53' mice exhibit enhanced DNA damage response, are tumor resistant and age normally
    The EMBO Journal, vol. 21, no. 22, Article ID 7594814, 10 pages, 2002
  63. Mammalian meiotic telomeres: composition and ultrastructure in telomerase-deficient mice
    European Journal of Cell Biology, vol. 81, no. 6, pp. 335–340, 2002
  64. Transformation of normal human cells in the absence of telomerase activation
    Cancer Cell, vol. 2, no. 5, pp. 401–413, 2002
  65. Mouse models to study the role of telomeres in cancer, aging and DNA repair
    European Journal of Cancer, vol. 38, no. 17, pp. 2222–2228, 2002
  66. A role for the Rb family of proteins in controlling telomere length
    Nature Genetics, vol. 32, no. 3, Article ID ng1011, 4 pages, 2002
  67. Opinion: Telomerase beyond telomeres
    Nature Reviews Cancer, vol. 2, no. 8, Article ID nrc862, 6 pages, 2002
  68. An Essential Role for Functional Telomeres in Mouse Germ Cells during Fertilization and Early Development
    Developmental Biology, vol. 249, no. 1, pp. 74–84, 2002
  69. Identification of Telomere-Dependent “Senescence-like” Arrest in Mouse Embryonic Fibroblasts
    Experimental Cell Research, vol. 276, no. 2, pp. 242–248, 2002
  70. Immunosenescence phenotypes in the telomerase knockout mouse
    Springer Seminars in Immunopathology, vol. 24, no. 1, pp. 75–85, 2002
  71. Putting the stress on senescence
    Current Opinion in Cell Biology, vol. 13, no. 6, pp. 748–753, 2001
  72. Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes
    The EMBO Journal, vol. 20, no. 11, pp. 2619–2630, 2001
  73. Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc-/- mice with short telomeres
    EMBO Reports, vol. 2, no. 9, pp. 800–807, 2001
  74. Identification of Functional Domains and Dominant Negative Mutations in Vertebrate Telomerase RNA Using an in Vivo Reconstitution System
    Journal of Biological Chemistry, vol. 276, no. 8, pp. 5856–5865, 2001
  75. Normal telomere length and chromosomal end capping in poly(ADP-ribose) polymerase-deficient mice and primary cells despite increased chromosomal instability
    The Journal of Cell Biology, vol. 154, no. 1, pp. 49–60, 2001
  76. The Absence of the DNA-Dependent Protein Kinase Catalytic Subunit in Mice Results in Anaphase Bridges and in Increased Telomeric Fusions with Normal Telomere Length and G-Strand Overhang
    Molecular and Cellular Biology, vol. 21, no. 11, pp. 3642–3651, 2001
  77. Telomeres in Cancer Therapy
    Journal of Biomedicine and Biotechnology, vol. 1, no. 1, pp. 3–4, 2001
  78. Short Telomeres Result in Organismal Hypersensitivity to Ionizing Radiation in Mammals
    Journal of Experimental Medicine, vol. 192, no. 11, pp. 1625–1636, 2000
  79. Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang
    EMBO Reports, vol. 1, no. 3, pp. 244–252, 2000
  80. Impaired germinal center reaction in mice with short telomeres
    The EMBO Journal, vol. 19, no. 3, pp. 472–481, 2000
  81. Secondary Structure of Vertebrate Telomerase RNA
    Cell, vol. 100, no. 5, pp. 503–514, 2000
  82. Nature Genetics, vol. 26, no. 1, pp. 114–117, 2000
  83. Nature Biotechnology, vol. 17, no. 4, pp. 313–313, 1999
  84. Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
    Cell, vol. 96, no. 5, pp. 701–712, 1999
  85. Disease states associated with telomerase deficiency appear earlier in mice with short telomeres
    The EMBO Journal, vol. 18, no. 11, pp. 2950–2960, 1999
  86. Telomere shortening in mTR-/- embryos is associated with failure to close the neural tube
    The EMBO Journal, vol. 18, no. 5, pp. 1172–1181, 1999
  87. Telomere Length Dynamics and Chromosomal Instability in Cells Derived from Telomerase Null Mice
    The Journal of Cell Biology, vol. 144, no. 4, pp. 589–601, 1999
  88. Telomeres and telomerase
    Genes & Development, vol. 13, no. 18, pp. 2353–2359, 1999
  89. The mouse telomerase RNA 5"-end lies just upstream of the telomerase template sequence
    Nucleic Acids Research, vol. 26, no. 2, pp. 532–536, 1998
  90. Expression of mouse telomerase catalytic subunit in embryos and adult tissues
    Proceedings of the National Academy of Sciences, vol. 95, no. 18, pp. 10471–10476, 1998
  91. Nature, vol. 392, no. 6676, pp. 569–574, 1998
  92. Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
    Cell, vol. 91, no. 1, pp. 25–34, 1997
  93. Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis
    Nature Genetics, vol. 12, no. 2, Article ID ng0296-200, 4 pages, 1996
  94. Primer Terminus Stabilization at the [IMAGE]29 DNA Polymerase Active Site
    Journal of Biological Chemistry, vol. 270, no. 6, pp. 2735–2740, 1995
  95. Structural and functional studies on ø29 DNA polymerase
    Chromosoma, vol. 102, no. S1, pp. S32–S38, 1992
  96. A general structure for DNA-dependent DNA polymerases
    Gene, vol. 100, pp. 27–38, 1991