Wolfgang A. Schulz
Wolfgang A. Schulz received his Ph.D. degree at the University of Tübingen, Germany, in 1985 after having studied biochemistry there. He then moved to cancer epigenetics, first as a Postdoctoral Fellow at the University of Pittsburgh, USA, and later at the University of Ulm, Germany. Since 1989, he has been employed at the Heinrich Heine University at Düsseldorf, Germany, initially in the Department of Physiological Chemistry and later in the Department of Urology, where he led the Research Lab. The main focus of his group concerns DNA methylation alterations in urological cancers. The group is probably best known for its investigations on the causes and consequences of the retroelement hypomethylation in cancer cells. Over the years, a range of related issues have been studied in the group, especially disturbances in cell cycle regulators and proliferation regulatory pathways in urothelial cancers, as well as polymorphisms in methyl group metabolism and carcinogen metabolism genes. Dr. Schulz has coauthored more than 100 research papers and published several review and conceptual articles. For many years, Dr. Schulz has served as an officer of the DNA Methylation Society (now Epigenetics Society). Beyond research, he has a particular interest in interdisciplinary teaching. For that purpose, he has written an advanced students' textbook entitled Molecular Biology of Human Cancers (Springer, 2005).
Biography Updated on 23 March 2007
Articles in Scholarly Journals [Incomplete List]
- Heparin-binding epidermal growth factor-like growth factor isoforms and epidermal growth factor receptor/ErbB1 expression in bladder cancer and their relation to clinical outcome
Cancer, vol. 109, no. 10, pp. 2016–2024, 2007 - A new and reliable culture system for superficial low-grade urothelial carcinoma of the bladder
World Journal of Urology, vol. 25, no. 3, pp. 297–302, 2007 - Molecular Cancer, vol. 6, no. 1, p. 14, 2007
- In situ detection of global DNA hypomethylation in exfoliative urine cytology of patients with suspected bladder cancer
Experimental and Molecular Pathology, vol. 82, no. 3, pp. 292–297, 2007 - Epigenetics of prostate cancer: beyond DNA methylation
Journal of Cellular and Molecular Medicine, vol. 10, no. 1, pp. 100–125, 2006 - Concomitant down-regulation of SPRY1 and SPRY2 in prostate carcinoma
Endocrine Related Cancer, vol. 13, no. 3, pp. 839–849, 2006 - Expression of death-associated protein kinase during tumour progression of human renal cell carcinomas: Hypermethylation-independent mechanisms of inactivation
European Journal of Cancer, vol. 42, no. 2, pp. 264–274, 2006 - Relationship of NKX3.1 and MYC Gene Copy Number Ratio and DNA Hypomethylation to Prostate Carcinoma Stage
European Urology, vol. 49, no. 1, pp. 169–175, 2006 - L1 Retrotransposons in Human Cancers
Journal of Biomedicine and Biotechnology, vol. 2006, Article ID 83672, 12 pages, 2006 - Genomic and Expression Analysis of the 3q25-q26 Amplification Unit Reveals TLOC1/SEC62 as a Probable Target Gene in Prostate Cancer
Molecular Cancer Research, vol. 4, no. 3, pp. 169–176, 2006 - Imbalances of chromosome arm 1p in pediatric and adult germ cell tumors are caused by true allelic loss: A combined comparative genomic hybridization and microsatellite analysis
Genes, Chromosomes and Cancer, vol. 45, no. 11, pp. 995–1006, 2006 - Epigenetic control of CTCFL/BORIS and OCT4 expression in urogenital malignancies
Biochemical Pharmacology, vol. 72, no. 11, pp. 1577–1588, 2006 - Understanding urothelial carcinoma through cancer pathways
International Journal of Cancer, vol. 119, no. 7, pp. 1513–1518, 2006 - Hedgehog signaling in normal urothelial cells and in urothelial carcinoma cell lines
Journal of Cellular Physiology, vol. 203, no. 2, pp. 372–377, 2005 - Multiple mechanisms downregulateCDKN1C in human bladder cancer
International Journal of Cancer, vol. 114, no. 3, pp. 406–413, 2005 - Application of a Modified Real-Time PCR Technique for Relative Gene Copy Number Quantification to the Determination of the Relationship between NKX3.1 Loss and MYC Gain in Prostate Cancer
Clinical Chemistry, vol. 51, no. 3, pp. 649–652, 2005 - Methylenetetrahydrofolate reductase C677T polymorphism and risk of adenocarcinoma of the upper gastrointestinal tract
Scandinavian Journal of Gastroenterology, vol. 40, no. 1, pp. 109–111, 2005 - Estimating cancer survival and clinical outcome based on genetic tumor progression scores
Bioinformatics, vol. 21, no. 10, pp. 2438–2446, 2005 - Molecular Cancer, vol. 4, no. 1, p. 16, 2005
- Causes and consequences of DNA hypomethylation in human cancer
Biochemistry and Cell Biology, vol. 83, no. 3, pp. 296–321, 2005 - Qualified Promise: DNA Methylation Assays for the Detection and Classification of Human Cancers
Journal of Biomedicine and Biotechnology, vol. 2005, no. 3, pp. 227–229, 2005 - Coordinate hypermethylation at specific genes in prostate carcinoma precedes LINE-1 hypomethylation
British Journal of Cancer, Article ID 6602030, 2004 - Suppression of clonogenicity by mammalian Dnmt1 mediated by the PCNA-binding domain
Biochemistry and Cell Biology, vol. 82, no. 5, pp. 589–596, 2004 - Inhibition of p53 function diminishes androgen receptor-mediated signaling in prostate cancer cell lines
Oncogene, vol. 23, no. 20, Article ID 1207346, 8 pages, 2004 - Denaturing high-performance liquid chromatography (DHPLC) as a reliable high-throughput prescreening method for aberrant promoter methylation in cancer
Human Mutation, vol. 23, no. 6, pp. 612–620, 2004 - Homozygous deletions ofCDKN2A caused by alternative mechanisms in various human cancer cell lines
Genes, Chromosomes and Cancer, vol. 42, no. 1, pp. 58–67, 2004 - Decreased Fas expression in advanced-stage bladder cancer is not related to p53 status
Urology, vol. 63, no. 2, pp. 392–397, 2004 - Methylenetetrahydrofolate reductase C677T polymorphism and predisposition towards esophageal squamous cell carcinoma in a German Caucasian and a northern Chinese population
Journal of Cancer Research and Clinical Oncology, vol. 130, no. 10, 2004 - Transcriptional regulation of the human LINE-1 retrotransposon L1.2B
Molecular Genetics and Genomics, vol. 270, no. 5, pp. 394–402, 2004 - Activities of MAP-Kinase Pathways in Normal Uroepithelial Cells and Urothelial Carcinoma Cell Lines
Experimental Cell Research, vol. 282, no. 1, pp. 48–57, 2003 - Peculiar structure and location of 9p21 homozygous deletion breakpoints in human cancer cells
Genes, Chromosomes and Cancer, vol. 37, no. 2, pp. 141–148, 2003 - Association betweenNAD(P)H: Quinone oxidoreductase 1 (NQ01) inactivating C609T polymorphism and adenocarcinoma of the upper gastrointestinal tract
International Journal of Cancer, vol. 107, no. 3, pp. 381–386, 2003 - Decrease of DNA methyltransferase 1 expression relative to cell proliferation in transitional cell carcinoma
International Journal of Cancer, vol. 104, no. 5, pp. 568–578, 2003 - Fibroblast Growth Factors and Their Receptors in Urological Cancers: Basic Research and Clinical Implications
European Urology, vol. 43, no. 3, pp. 309–319, 2003 - Downregulation of CD44v6 in colorectal carcinomas is associated with hypermethylation of the CD44 promoter region
Experimental and Molecular Pathology, vol. 74, no. 3, pp. 262–266, 2003 - E-cadherin involved in inactivation of WNT/ß-catenin signalling in urothelial carcinoma and normal urothelial cells
British Journal of Cancer, vol. 88, no. 12, Article ID 6601031, 6 pages, 2003 - Association of NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism with esophageal squamous cell carcinoma in a German Caucasian and a northern Chinese population
Carcinogenesis, vol. 24, no. 5, pp. 905–909, 2003 - Molecular biology of prostate cancer
Molecular Human Reproduction, vol. 9, no. 8, pp. 437–448, 2003 - p21 and p53 Immunostaining and Survival following Systemic Chemotherapy for Urothelial Cancer
Urologia Internationalis, vol. 69, no. 3, pp. 174–180, 2002 - Genomewide DNA hypomethylation is associated with alterations on chromosome 8 in prostate carcinoma
Genes, Chromosomes and Cancer, vol. 35, no. 1, pp. 58–65, 2002 - Refined mapping of allele loss at chromosome 10q23-26 in prostate cancer
The Prostate, vol. 50, no. 3, pp. 135–144, 2002 - Hypermethylation of the tumor necrosis factor receptor superfamily 6 (APT1, Fas, CD95/Apo-1) gene promoter at rel/nuclear factor ?B sites in prostatic carcinoma
Molecular Carcinogenesis, vol. 32, no. 1, pp. 36–43, 2001 - Destabilization of chromosome 9 in transitional cell carcinoma of the urinary bladder
British Journal of Cancer, vol. 85, no. 12, Article ID 6692154, 6 pages, 2001 - Polymorphic methyl group metabolism genes in patients with transitional cell carcinoma of the urinary bladder
Mutation Research/Mutation Research Genomics, vol. 458, no. 1-2, pp. 49–54, 2001 - Cyclin-dependent kinase inhibitor ?27KIP1 is expressed preferentially in early stages of urothelial carcinoma
Urology, vol. 56, no. 4, pp. 689–695, 2000 - Decreased expression of p57KIP2mRNA in human bladder cancer
British Journal of Cancer, vol. 83, no. 5, pp. 626–631, 2000 - Methyl group metabolism gene polymorphisms and susceptibility to prostatic carcinoma
The Prostate, vol. 45, no. 3, pp. 225–231, 2000 - Phenol sulphotransferase SULT 1A1 polymorphism in prostate cancer: lack of association
Archives of Toxicology, vol. 74, no. 4-5, pp. 222–225, 2000 - Glutathione transferase isozyme genotypes in patients with prostate and bladder carcinoma
Archives of Toxicology, vol. 74, no. 9, pp. 521–526, 2000 - Novel mutations of the von Hippel-Lindau tumor-suppressor gene and rare DNA hypermethylation in renal-cell carcinoma cell lines of the clear-cell type
International Journal of Cancer, vol. 87, no. 5, pp. 650–653, 2000 - Loss of HNF1? function in human renal cell carcinoma: Frequent mutations in theVHL gene but not theHNF1? gene
Molecular Carcinogenesis, vol. 24, no. 4, pp. 305–314, 1999 - Over-expression and amplification of the c-myc gene in human urothelial carcinoma
International Journal of Cancer, vol. 84, no. 2, pp. 169–173, 1999 - DNA methylation and expression of LINE-1 and HERV-K provirus sequences in urothelial and renal cell carcinomas
British Journal of Cancer, vol. 80, no. 9, pp. 1312–1321, 1999 - High frequency of alterations in DNA methylation in adenocarcinoma of the prostate
The Prostate, vol. 39, no. 3, pp. 166–174, 1999 - Expression of G1S Transition Regulatory Molecules in Human Urothelial Cancer
Cancer Science, vol. 89, no. 7, pp. 719–726, 1998 - Predictive Value of Molecular Alterations for the Prognosis of Urothelial Carcinoma
Cancer Detection Prevention, vol. 22, no. 5, pp. 422–429, 1998 - Predisposition towards urolithiasis associated with the NQ01 null-allele
Pharmacogenetics, vol. 8, no. 5, pp. 453–454, 1998 - Increased frequency of a null-allele for NAD(P)H: quinone oxidoreductase in patients with urological malignancies
Pharmacogenetics, vol. 7, no. 3, pp. 235–239, 1997 - Adjacent guanines as preferred sites for strand breaks in plasmid DNA irradiated with 193 nm and 248 nm UV laser light
Journal of Photochemistry and Photobiology B: Biology, vol. 32, no. 1-2, pp. 97–102, 1996 - Induction of Gap Junctional Communication by 4-Oxoretinoic Acid Generated from Its Precursor Canthaxanthin
Archives of Biochemistry and Biophysics, vol. 317, no. 2, pp. 423–428, 1995 - Efficacy of All-trans-ß-Carotene, Canthaxanthin, and All-trans, 9-cis-, and 4-Oxoretinoic Acids in Inducing Differentiation of an F9 Embryonal Carcinoma RARß-lacZ Reporter Cell Line
Archives of Biochemistry and Biophysics, vol. 316, no. 2, pp. 665–672, 1995 - Regulation of DNA methyltransferase during differentiation of F9 mouse embryonal carcinoma cells
Journal of Cellular Physiology, vol. 165, no. 2, pp. 284–290, 1995 - Exemption of Satellite DNA from Demethylation in Immortalized Differentiated Derivatives of F9 Mouse Embryonal Carcinoma Cells
Experimental Cell Research, vol. 210, no. 2, pp. 192–200, 1994 - Biochemistry, vol. 30, no. 25, pp. 6283–6289, 1991
- Constitutive c-myc expression enhances proliferation of differentiating F9 teratocarcinoma cells
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol. 1013, no. 2, pp. 125–132, 1989 - In developing brown adipose tissue c-myc protooncogene expression is restricted to early differentiation stages
Cell Differentiation and Development, vol. 27, no. 3, pp. 243–248, 1989 - Albumin and ?-fetoprotein gene expression and DNA methylation in rat hepatoma cell lines
Experimental Cell Research, vol. 174, no. 2, pp. 433–447, 1988 - The distribution of metastases in the liver
Virchows Archiv A Pathological Anatomy and Histology, vol. 394, no. 1-2, pp. 89–96, 1981