Wolfgang A. Schulz

Wolfgang A. Schulz received his Ph.D. degree at the University of Tübingen, Germany, in 1985 after having studied biochemistry there. He then moved to cancer epigenetics, first as a Postdoctoral Fellow at the University of Pittsburgh, USA, and later at the University of Ulm, Germany. Since 1989, he has been employed at the Heinrich Heine University at Düsseldorf, Germany, initially in the Department of Physiological Chemistry and later in the Department of Urology, where he led the Research Lab. The main focus of his group concerns DNA methylation alterations in urological cancers. The group is probably best known for its investigations on the causes and consequences of the retroelement hypomethylation in cancer cells. Over the years, a range of related issues have been studied in the group, especially disturbances in cell cycle regulators and proliferation regulatory pathways in urothelial cancers, as well as polymorphisms in methyl group metabolism and carcinogen metabolism genes. Dr. Schulz has coauthored more than 100 research papers and published several review and conceptual articles. For many years, Dr. Schulz has served as an officer of the DNA Methylation Society (now Epigenetics Society). Beyond research, he has a particular interest in interdisciplinary teaching. For that purpose, he has written an advanced students' textbook entitled Molecular Biology of Human Cancers (Springer, 2005).

Biography Updated on 23 March 2007

Articles in Scholarly Journals [Incomplete List]

  1. Heparin-binding epidermal growth factor-like growth factor isoforms and epidermal growth factor receptor/ErbB1 expression in bladder cancer and their relation to clinical outcome
    Cancer, vol. 109, no. 10, pp. 2016–2024, 2007
  2. A new and reliable culture system for superficial low-grade urothelial carcinoma of the bladder
    World Journal of Urology, vol. 25, no. 3, pp. 297–302, 2007
  3. Molecular Cancer, vol. 6, no. 1, p. 14, 2007
  4. In situ detection of global DNA hypomethylation in exfoliative urine cytology of patients with suspected bladder cancer
    Experimental and Molecular Pathology, vol. 82, no. 3, pp. 292–297, 2007
  5. Epigenetics of prostate cancer: beyond DNA methylation
    Journal of Cellular and Molecular Medicine, vol. 10, no. 1, pp. 100–125, 2006
  6. Concomitant down-regulation of SPRY1 and SPRY2 in prostate carcinoma
    Endocrine Related Cancer, vol. 13, no. 3, pp. 839–849, 2006
  7. Expression of death-associated protein kinase during tumour progression of human renal cell carcinomas: Hypermethylation-independent mechanisms of inactivation
    European Journal of Cancer, vol. 42, no. 2, pp. 264–274, 2006
  8. Relationship of NKX3.1 and MYC Gene Copy Number Ratio and DNA Hypomethylation to Prostate Carcinoma Stage
    European Urology, vol. 49, no. 1, pp. 169–175, 2006
  9. L1 Retrotransposons in Human Cancers
    Journal of Biomedicine and Biotechnology, vol. 2006, Article ID 83672, 12 pages, 2006
  10. Genomic and Expression Analysis of the 3q25-q26 Amplification Unit Reveals TLOC1/SEC62 as a Probable Target Gene in Prostate Cancer
    Molecular Cancer Research, vol. 4, no. 3, pp. 169–176, 2006
  11. Imbalances of chromosome arm 1p in pediatric and adult germ cell tumors are caused by true allelic loss: A combined comparative genomic hybridization and microsatellite analysis
    Genes, Chromosomes and Cancer, vol. 45, no. 11, pp. 995–1006, 2006
  12. Epigenetic control of CTCFL/BORIS and OCT4 expression in urogenital malignancies
    Biochemical Pharmacology, vol. 72, no. 11, pp. 1577–1588, 2006
  13. Understanding urothelial carcinoma through cancer pathways
    International Journal of Cancer, vol. 119, no. 7, pp. 1513–1518, 2006
  14. Hedgehog signaling in normal urothelial cells and in urothelial carcinoma cell lines
    Journal of Cellular Physiology, vol. 203, no. 2, pp. 372–377, 2005
  15. Multiple mechanisms downregulateCDKN1C in human bladder cancer
    International Journal of Cancer, vol. 114, no. 3, pp. 406–413, 2005
  16. Application of a Modified Real-Time PCR Technique for Relative Gene Copy Number Quantification to the Determination of the Relationship between NKX3.1 Loss and MYC Gain in Prostate Cancer
    Clinical Chemistry, vol. 51, no. 3, pp. 649–652, 2005
  17. Methylenetetrahydrofolate reductase C677T polymorphism and risk of adenocarcinoma of the upper gastrointestinal tract
    Scandinavian Journal of Gastroenterology, vol. 40, no. 1, pp. 109–111, 2005
  18. Estimating cancer survival and clinical outcome based on genetic tumor progression scores
    Bioinformatics, vol. 21, no. 10, pp. 2438–2446, 2005
  19. Molecular Cancer, vol. 4, no. 1, p. 16, 2005
  20. Causes and consequences of DNA hypomethylation in human cancer
    Biochemistry and Cell Biology, vol. 83, no. 3, pp. 296–321, 2005
  21. Qualified Promise: DNA Methylation Assays for the Detection and Classification of Human Cancers
    Journal of Biomedicine and Biotechnology, vol. 2005, no. 3, pp. 227–229, 2005
  22. Coordinate hypermethylation at specific genes in prostate carcinoma precedes LINE-1 hypomethylation
    British Journal of Cancer, Article ID 6602030, 2004
  23. Suppression of clonogenicity by mammalian Dnmt1 mediated by the PCNA-binding domain
    Biochemistry and Cell Biology, vol. 82, no. 5, pp. 589–596, 2004
  24. Inhibition of p53 function diminishes androgen receptor-mediated signaling in prostate cancer cell lines
    Oncogene, vol. 23, no. 20, Article ID 1207346, 8 pages, 2004
  25. Denaturing high-performance liquid chromatography (DHPLC) as a reliable high-throughput prescreening method for aberrant promoter methylation in cancer
    Human Mutation, vol. 23, no. 6, pp. 612–620, 2004
  26. Homozygous deletions ofCDKN2A caused by alternative mechanisms in various human cancer cell lines
    Genes, Chromosomes and Cancer, vol. 42, no. 1, pp. 58–67, 2004
  27. Decreased Fas expression in advanced-stage bladder cancer is not related to p53 status
    Urology, vol. 63, no. 2, pp. 392–397, 2004
  28. Methylenetetrahydrofolate reductase C677T polymorphism and predisposition towards esophageal squamous cell carcinoma in a German Caucasian and a northern Chinese population
    Journal of Cancer Research and Clinical Oncology, vol. 130, no. 10, 2004
  29. Transcriptional regulation of the human LINE-1 retrotransposon L1.2B
    Molecular Genetics and Genomics, vol. 270, no. 5, pp. 394–402, 2004
  30. Activities of MAP-Kinase Pathways in Normal Uroepithelial Cells and Urothelial Carcinoma Cell Lines
    Experimental Cell Research, vol. 282, no. 1, pp. 48–57, 2003
  31. Peculiar structure and location of 9p21 homozygous deletion breakpoints in human cancer cells
    Genes, Chromosomes and Cancer, vol. 37, no. 2, pp. 141–148, 2003
  32. Association betweenNAD(P)H: Quinone oxidoreductase 1 (NQ01) inactivating C609T polymorphism and adenocarcinoma of the upper gastrointestinal tract
    International Journal of Cancer, vol. 107, no. 3, pp. 381–386, 2003
  33. Decrease of DNA methyltransferase 1 expression relative to cell proliferation in transitional cell carcinoma
    International Journal of Cancer, vol. 104, no. 5, pp. 568–578, 2003
  34. Fibroblast Growth Factors and Their Receptors in Urological Cancers: Basic Research and Clinical Implications
    European Urology, vol. 43, no. 3, pp. 309–319, 2003
  35. Downregulation of CD44v6 in colorectal carcinomas is associated with hypermethylation of the CD44 promoter region
    Experimental and Molecular Pathology, vol. 74, no. 3, pp. 262–266, 2003
  36. E-cadherin involved in inactivation of WNT/ß-catenin signalling in urothelial carcinoma and normal urothelial cells
    British Journal of Cancer, vol. 88, no. 12, Article ID 6601031, 6 pages, 2003
  37. Association of NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism with esophageal squamous cell carcinoma in a German Caucasian and a northern Chinese population
    Carcinogenesis, vol. 24, no. 5, pp. 905–909, 2003
  38. Molecular biology of prostate cancer
    Molecular Human Reproduction, vol. 9, no. 8, pp. 437–448, 2003
  39. p21 and p53 Immunostaining and Survival following Systemic Chemotherapy for Urothelial Cancer
    Urologia Internationalis, vol. 69, no. 3, pp. 174–180, 2002
  40. Genomewide DNA hypomethylation is associated with alterations on chromosome 8 in prostate carcinoma
    Genes, Chromosomes and Cancer, vol. 35, no. 1, pp. 58–65, 2002
  41. Refined mapping of allele loss at chromosome 10q23-26 in prostate cancer
    The Prostate, vol. 50, no. 3, pp. 135–144, 2002
  42. Hypermethylation of the tumor necrosis factor receptor superfamily 6 (APT1, Fas, CD95/Apo-1) gene promoter at rel/nuclear factor ?B sites in prostatic carcinoma
    Molecular Carcinogenesis, vol. 32, no. 1, pp. 36–43, 2001
  43. Destabilization of chromosome 9 in transitional cell carcinoma of the urinary bladder
    British Journal of Cancer, vol. 85, no. 12, Article ID 6692154, 6 pages, 2001
  44. Polymorphic methyl group metabolism genes in patients with transitional cell carcinoma of the urinary bladder
    Mutation Research/Mutation Research Genomics, vol. 458, no. 1-2, pp. 49–54, 2001
  45. Cyclin-dependent kinase inhibitor ?27KIP1 is expressed preferentially in early stages of urothelial carcinoma
    Urology, vol. 56, no. 4, pp. 689–695, 2000
  46. Decreased expression of p57KIP2mRNA in human bladder cancer
    British Journal of Cancer, vol. 83, no. 5, pp. 626–631, 2000
  47. Methyl group metabolism gene polymorphisms and susceptibility to prostatic carcinoma
    The Prostate, vol. 45, no. 3, pp. 225–231, 2000
  48. Phenol sulphotransferase SULT 1A1 polymorphism in prostate cancer: lack of association
    Archives of Toxicology, vol. 74, no. 4-5, pp. 222–225, 2000
  49. Glutathione transferase isozyme genotypes in patients with prostate and bladder carcinoma
    Archives of Toxicology, vol. 74, no. 9, pp. 521–526, 2000
  50. Novel mutations of the von Hippel-Lindau tumor-suppressor gene and rare DNA hypermethylation in renal-cell carcinoma cell lines of the clear-cell type
    International Journal of Cancer, vol. 87, no. 5, pp. 650–653, 2000
  51. Loss of HNF1? function in human renal cell carcinoma: Frequent mutations in theVHL gene but not theHNF1? gene
    Molecular Carcinogenesis, vol. 24, no. 4, pp. 305–314, 1999
  52. Over-expression and amplification of the c-myc gene in human urothelial carcinoma
    International Journal of Cancer, vol. 84, no. 2, pp. 169–173, 1999
  53. DNA methylation and expression of LINE-1 and HERV-K provirus sequences in urothelial and renal cell carcinomas
    British Journal of Cancer, vol. 80, no. 9, pp. 1312–1321, 1999
  54. High frequency of alterations in DNA methylation in adenocarcinoma of the prostate
    The Prostate, vol. 39, no. 3, pp. 166–174, 1999
  55. Expression of G1S Transition Regulatory Molecules in Human Urothelial Cancer
    Cancer Science, vol. 89, no. 7, pp. 719–726, 1998
  56. Predictive Value of Molecular Alterations for the Prognosis of Urothelial Carcinoma
    Cancer Detection Prevention, vol. 22, no. 5, pp. 422–429, 1998
  57. Predisposition towards urolithiasis associated with the NQ01 null-allele
    Pharmacogenetics, vol. 8, no. 5, pp. 453–454, 1998
  58. Increased frequency of a null-allele for NAD(P)H: quinone oxidoreductase in patients with urological malignancies
    Pharmacogenetics, vol. 7, no. 3, pp. 235–239, 1997
  59. Adjacent guanines as preferred sites for strand breaks in plasmid DNA irradiated with 193 nm and 248 nm UV laser light
    Journal of Photochemistry and Photobiology B: Biology, vol. 32, no. 1-2, pp. 97–102, 1996
  60. Induction of Gap Junctional Communication by 4-Oxoretinoic Acid Generated from Its Precursor Canthaxanthin
    Archives of Biochemistry and Biophysics, vol. 317, no. 2, pp. 423–428, 1995
  61. Efficacy of All-trans-ß-Carotene, Canthaxanthin, and All-trans, 9-cis-, and 4-Oxoretinoic Acids in Inducing Differentiation of an F9 Embryonal Carcinoma RARß-lacZ Reporter Cell Line
    Archives of Biochemistry and Biophysics, vol. 316, no. 2, pp. 665–672, 1995
  62. Regulation of DNA methyltransferase during differentiation of F9 mouse embryonal carcinoma cells
    Journal of Cellular Physiology, vol. 165, no. 2, pp. 284–290, 1995
  63. Exemption of Satellite DNA from Demethylation in Immortalized Differentiated Derivatives of F9 Mouse Embryonal Carcinoma Cells
    Experimental Cell Research, vol. 210, no. 2, pp. 192–200, 1994
  64. Biochemistry, vol. 30, no. 25, pp. 6283–6289, 1991
  65. Constitutive c-myc expression enhances proliferation of differentiating F9 teratocarcinoma cells
    Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol. 1013, no. 2, pp. 125–132, 1989
  66. In developing brown adipose tissue c-myc protooncogene expression is restricted to early differentiation stages
    Cell Differentiation and Development, vol. 27, no. 3, pp. 243–248, 1989
  67. Albumin and ?-fetoprotein gene expression and DNA methylation in rat hepatoma cell lines
    Experimental Cell Research, vol. 174, no. 2, pp. 433–447, 1988
  68. The distribution of metastases in the liver
    Virchows Archiv A Pathological Anatomy and Histology, vol. 394, no. 1-2, pp. 89–96, 1981