David Muddiman

David Muddiman is currently a Professor of Chemistry and Director of the W. M. Keck FT-ICR Mass Spectrometry Laboratory at North Carolina State University in Raleigh, NC. Prior to moving his research group to NC State, David was a Professor of Biochemistry and Director of the Mayo Proteomics Research Center at the Mayo Clinic College of Medicine in Rochester, Minn. David was an Associate Professor of Chemistry at Virginia Commonwealth University where he began his academic career as an Assistant Professor in 1997. David was born in Long Beach, Calif, in 1967, but spent most of his formidable years in a small town in Pennsylvania. David received his B.S. degree in chemistry from Gannon University, Erie, Pa, in 1990 and his Ph.D. degree in analytical chemistry from the University of Pittsburgh in 1995 under the auspices of David M. Hercules. He then was a Postdoctoral Fellow at Pacific Northwest National Laboratory in the Environmental Molecular Sciences Laboratory working with Richard D. Smith from 1995 to 1997. David has served on over 25 NIH study sections since 1999 and reviews for over 30 scientific journals. He has been a Guest Editor for Analytical and Bioanalytical Chemistry, Mass Spectrometry Reviews, and the Journal of the American Society for Mass Spectrometry. He currently serves on the Editorial Advisory Board of Mass Spectrometry Reviews, Journal of Proteome Research, Rapid Communications in Mass Spectrometry, and the Journal of the American Society for Mass Spectrometry. He also serves on the advisory board of the NHMFL, Florida State University, and the Yale Neuroproteomics Center. His group has presented over 200 invited lectures and presentations at national and international meetings, has published over 110 peer-reviewed papers, and has one US patent. He is the recipient of the 2004 ACS Arthur F. Findeis Award, the 1999 American Society for Mass Spectrometry Research Award, and the Safford Award, University of Pittsburgh, for Excellence in Teaching.

Biography Updated on 8 January 2008

Personal Home Page

http://www.ncsu.edu/chemistry/facultyPages/WMKeck_FTICR.html

Articles in Scholarly Journals [Incomplete List]

  1. Differential protein expression in male and female human lumbar cerebrospinal fluid using iTRAQ reagents after abundant protein depletion
    PROTEOMICS, vol. 7, no. 20, pp. 3726–3734, 2007
  2. Effect of matrix crystal structure on ion abundance of carbohydrates by matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry
    Rapid Communications in Mass Spectrometry, vol. 21, no. 5, pp. 807–811, 2007
  3. Direct characterization of intact polypeptides by matrix-assisted laser desorption electrospray ionization quadrupole Fourier transform ion cyclotron resonance mass spectrometry
    Rapid Communications in Mass Spectrometry, vol. 21, no. 7, pp. 1150–1154, 2007
  4. Understanding the influence of post-excite radius and axial confinement on quantitative proteomic measurements using Fourier transform ion cyclotron resonance mass spectrometry
    Rapid Communications in Mass Spectrometry, vol. 21, no. 7, pp. 1196–1204, 2007
  5. Quantitative comparison of a flared and a standard heated metal capillary inlet with a voltage-assisted air amplifier on an electrospray ionization linear ion trap mass spectrometer
    Rapid Communications in Mass Spectrometry, vol. 21, no. 19, pp. 3207–3212, 2007
  6. Sub Parts-Per-Million Mass Measurement Accuracy of Intact Proteins and Product Ions Achieved Using a Dual Electrospray Ionization Quadrupole Fourier Transform Ion Cyclotron Resonance Mass Spectrometer
    Journal of the American Society for Mass Spectrometry, vol. 18, no. 1, pp. 1–7, 2007
  7. Detection of Attomole Amounts of Analyte by Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) Determined Using Fluorescence Spectroscopy
    Journal of the American Society for Mass Spectrometry, vol. 18, no. 6, pp. 1093–1096, 2007
  8. Remote Mass Spectrometric Sampling of Electrospray- and Desorption Electrospray-Generated Ions Using an Air Ejector
    Journal of the American Society for Mass Spectrometry, vol. 18, no. 10, pp. 1844–1847, 2007
  9. Probing the Mechanisms of an Air Amplifier Using a LTQ-FT-ICR-MS and Fluorescence Spectroscopy
    Journal of the American Society for Mass Spectrometry, vol. 18, no. 11, pp. 1909–1913, 2007
  10. Parts-Per-Billion Mass Measurement Accuracy Achieved through the Combination of Multiple Linear Regression and Automatic Gain Control in a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer
    Analytical Chemistry, vol. 79, no. 13, pp. 5058–5063, 2007
  11. Achieving Augmented Limits of Detection for Peptides with Hydrophobic Alkyl Tags
    Analytical Chemistry, vol. 79, no. 11, pp. 3989–3995, 2007
  12. Carbohydrate Analysis by Desorption Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
    Analytical Chemistry, vol. 79, no. 22, pp. 8812–8815, 2007
  13. Dual Electrospray Ion Source for Electron-Transfer Dissociation on a Hybrid Linear Ion Trap-Orbitrap Mass Spectrometer
    Analytical Chemistry, vol. 79, no. 20, pp. 7916–7919, 2007
  14. Coordination-Driven Self-Assembly of Metallodendrimers Possessing Well-Defined and Controllable Cavities as Cores
    Journal of the American Chemical Society, vol. 129, no. 7, pp. 2120–2129, 2007
  15. A Highly Efficient Approach to the Self-Assembly of Hexagonal Cavity-Cored Tris[2]pseudorotaxanes from Several Components via Multiple Noncovalent Interactions
    Journal of the American Chemical Society, vol. 129, no. 46, pp. 14187–14189, 2007
  16. Details of the Structure Determination of the Sulfated Steroids PSDS and PADS: New Components of the Sea Lamprey (Petromyzon marinus) Migratory Pheromone
    The Journal of Organic Chemistry, vol. 72, no. 20, pp. 7544–7550, 2007
  17. Epithelial Ovarian Cancer: Disease Etiology, Treatment, Detection, and Investigational Gene, Metabolite, and Protein Biomarkers
    Journal of Proteome Research, vol. 6, no. 8, pp. 2936–2962, 2007
  18. Secreted Proteome Profiling in Human RPE Cell Cultures Derived from Donors with Age Related Macular Degeneration and Age Matched Healthy Donors
    Journal of Proteome Research, vol. 6, no. 4, pp. 1615–1615, 2007
  19. Journal of Proteome Research, vol. 5, no. 2, pp. 370–377, 2006
  20. A Method for Automatically Interpreting Mass Spectra of 18O-Labeled Isotopic Clusters
    Molecular & Cellular Proteomics, vol. 6, no. 2, pp. 305–318, 2006
  21. Journal of the American Chemical Society, vol. 128, no. 31, pp. 10014–10015, 2006
  22. The Journal of Organic Chemistry, vol. 71, no. 17, pp. 6644–6647, 2006
  23. Biochemistry, vol. 45, no. 9, pp. 2852–2861, 2006
  24. Generation and Detection of Multiply-Charged Peptides and Proteins by Matrix-Assisted Laser Desorption Electrospray Ionization (MALDESI) Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
    Journal of the American Society for Mass Spectrometry, vol. 17, no. 12, pp. 1712–1716, 2006
  25. Direct high-resolution peptide and protein analysis by desorption electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry
    Rapid Communications in Mass Spectrometry, vol. 20, no. 22, pp. 3409–3411, 2006
  26. Accessible proteomics space and its implications for peak capacity for zero-, one- and two-dimensional separations coupled with FT-ICR and TOF mass spectrometry
    Journal of Mass Spectrometry, vol. 41, no. 3, pp. 281–288, 2006
  27. Deja Vu All Over Again: Skin Cap Still Contains a High-Potency Glucocorticosteroid
    Archives of Dermatology, vol. 141, no. 6, pp. 801–803, 2005
  28. Effect of post-excitation radius on ion abundance, mass measurement accuracy, and isotopic distributions in Fourier transform ion cyclotron resonance mass spectrometry
    Rapid Communications in Mass Spectrometry, vol. 19, no. 7, pp. 915–918, 2005
  29. Normalization of relative peptide ratios derived from in-gel digests: applications to protein variant analysis at the peptide level
    Rapid Communications in Mass Spectrometry, vol. 19, no. 19, pp. 2871–2877, 2005
  30. Leveling Response Factors in the Electrospray Ionization Process Using a Heated Capillary Interface
    Journal of the American Society for Mass Spectrometry, vol. 16, no. 5, pp. 772–778, 2005
  31. Accurate Mass Precursor Ion Data and Tandem Mass Spectrometry Identify a Class I Human Leukocyte Antigen A*0201–Presented Peptide Originating from Vaccinia Virus
    Journal of the American Society for Mass Spectrometry, vol. 16, no. 11, pp. 1812–1817, 2005
  32. Protein expression profiling of CLL B cells using replicate off-line strong cation exchange chromatography and LC–MS/MS
    Journal of Chromatography B, vol. 819, no. 1, pp. 33–39, 2005
  33. Derivatives of pentamidine designed to target the lipophosphoglycan
    Tetrahedron Letters, vol. 46, no. 4, pp. 695–698, 2005
  34. Analytical Chemistry, vol. 77, no. 8, pp. 2406–2414, 2005
  35. Analytical Chemistry, vol. 77, no. 19, pp. 6174–6183, 2005
  36. Journal of the American Chemical Society, vol. 127, no. 34, pp. 12131–12139, 2005
  37. Journal of Proteome Research, vol. 4, no. 3, pp. 837–845, 2005
  38. Journal of Proteome Research, vol. 4, no. 2, pp. 424–434, 2005
  39. A new history of ASLIB, 1924-1950
    Journal of Documentation, vol. 61, no. 3, pp. 402–428, 2005
  40. Primary Trabecular Meshwork Cells Incubated in Human Aqueous Humor Differ from Cells Incubated in Serum Supplements
    Investigative Ophthalmology & Visual Science, vol. 46, no. 8, pp. 2848–2856, 2005
  41. Journal of Proteome Research, vol. 4, no. 4, pp. 1310–1317, 2005
  42. Journal of Proteome Research, vol. 4, no. 6, pp. 2243–2249, 2005
  43. Quantitative mass spectral evidence for the absence of circulating brain natriuretic peptide (BNP-32) in severe human heart failure
    Proceedings of the National Academy of Sciences, vol. 102, no. 48, pp. 17442–17447, 2005
  44. Nucleic Acid Analysis by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry at the Beginning of the Twenty-First Century
    Current Pharmaceutical Design, vol. 11, no. 20, pp. 2593–2613, 2005
  45. Identification and Characterization of Novel, Naturally Processed Measles Virus Class II HLA-DRB1 Peptides
    Journal of Virology, vol. 78, no. 1, pp. 42–51, 2004
  46. Androgens Negatively Regulate Forkhead Transcription Factor FKHR (FOXO1) through a Proteolytic Mechanism in Prostate Cancer Cells
    Journal of Biological Chemistry, vol. 279, no. 14, pp. 13866–13877, 2004
  47. Journal of Proteome Research, vol. 3, no. 3, pp. 658–661, 2004
  48. Identification of Transthyretin Variants by Sequential Proteomic and Genomic Analysis
    Clinical Chemistry, vol. 50, no. 9, pp. 1544–1552, 2004
  49. Detection of Genetic Variants of Transthyretin by Liquid Chromatography-Dual Electrospray Ionization Fourier-Transform Ion-Cyclotron-Resonance Mass Spectrometry
    Clinical Chemistry, vol. 50, no. 9, pp. 1535–1543, 2004
  50. Journal of Proteome Research, vol. 3, no. 3, pp. 644–652, 2004
  51. Analytical Chemistry, vol. 76, no. 14, pp. 4118–4122, 2004
  52. Analytical Chemistry, vol. 76, no. 17, pp. 5097–5103, 2004
  53. Informed use of proteolytic inhibitors in biomarker discovery
    Rapid Communications in Mass Spectrometry, vol. 18, no. 9, pp. 1001–1002, 2004
  54. Utility of accurate monoisotopic mass measurements to confidently identify lambda exonuclease generated single-stranded amplicons containing 7-deaza analogs by electrospray ionization FT-ICR mass spectrometry
    International Journal of Mass Spectrometry, vol. 234, no. 1-3, pp. 79–87, 2004
  55. Determination of the relative energies of activation for the dissociation of aromatic versus aliphatic phosphopeptides by ESI-FTICR-MS and IRMPD
    Journal of the American Society for Mass Spectrometry, vol. 15, no. 1, pp. 121–127, 2004
  56. A method for calculating 16o/18o peptide ion ratios for the relative quantification of proteomes
    Journal of the American Society for Mass Spectrometry, vol. 15, no. 4, pp. 437–445, 2004
  57. Mass spectral determination of skeletal/cardiac actin isoform ratios in cardiac muscle
    Rapid Communications in Mass Spectrometry, vol. 17, no. 13, pp. 1467–1471, 2003
  58. Determination of a correction to improve mass measurement accuracy of isotopically unresolved polymerase chain reaction amplicons by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry
    Rapid Communications in Mass Spectrometry, vol. 17, no. 15, pp. 1714–1722, 2003
  59. Enzymatic strategies for the characterization of nucleic acids by electrospray ionization mass spectrometry
    Rapid Communications in Mass Spectrometry, vol. 17, no. 24, pp. 2699–2706, 2003
  60. Advantages of thermococcus kodakaraenis (KOD) DNA Polymerase for PCR-mass spectrometry based analyses
    Journal of the American Society for Mass Spectrometry, vol. 14, no. 6, pp. 601–604, 2003
  61. Analytical Chemistry, vol. 75, no. 6, pp. 1331–1339, 2003
  62. Analytical Chemistry, vol. 75, no. 14, pp. 3411–3418, 2003
  63. 1H NMR and electrospray mass spectrometry of the mono-ionized bis(2,2'-bis(4,5-dimethylimidazole)chloronitrosylruthenium(II) complex ([Ru(NO)Cl(LH2)2]+, LH2=2,2'-bis(4,5-dimethylimidazole)
    Inorganica Chimica Acta, vol. 343, pp. 317–328, 2003
  64. Naturally processed measles virus peptide eluted from class II HLA-DRB1*03 recognized by T lymphocytes from human blood
    Virology, vol. 312, no. 2, pp. 495–506, 2003
  65. Journal of the American Chemical Society, vol. 125, no. 32, pp. 9647–9652, 2003
  66. Red information scientist: the information career of J.D. Bernal
    Journal of Documentation, vol. 59, no. 4, pp. 387–409, 2003
  67. Journal of the American Chemical Society, vol. 124, no. 23, pp. 6546–6547, 2002
  68. CEPH family 1362 STR database: an online resource for characterization of PCR products using electrospray ionization mass spectrometry
    Journal of the American Society for Mass Spectrometry, vol. 13, no. 1, pp. 89–90, 2002
  69. Solution composition and thermal denaturation for the production of single-stranded PCR amplicons: piperidine-induced destabilization of the DNA duplex?
    Journal of the American Society for Mass Spectrometry, vol. 13, no. 3, pp. 232–240, 2002
  70. Evaluation of sample preparation techniques for mass measurements of PCR products using ESI-FT-ICR mass spectrometry
    Journal of the American Society for Mass Spectrometry, vol. 13, no. 4, pp. 338–344, 2002
  71. Tailoring the gas-phase dissociation and determining the relative energy of activation for dissociation of 7-deaza purine modified oligonucleotides containing a repeating motif
    International Journal of Mass Spectrometry, vol. 219, no. 1, pp. 139–150, 2002
  72. Dual-micro-ESI source for precise mass determination on a quadrupole time-of-flight mass spectrometer for genomic and proteomic applications
    Analytical and Bioanalytical Chemistry, vol. 373, no. 7, pp. 538–546, 2002
  73. In celebration of the 70th birthday of Dr David M. Hercules
    Analytical and Bioanalytical Chemistry, vol. 373, no. 7, pp. 517–518, 2002
  74. Genotyping short tandem repeats using flow injection and electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry
    Rapid Communications in Mass Spectrometry, vol. 15, no. 5, pp. 348–350, 2001
  75. Impact of ion cloud densities on the measurement of relative ion abundances in Fourier transform ion cyclotron resonance mass spectrometry: experimental observations of coulombically induced cyclotron radius perturbations and ion cloud dephasing rates
    Journal of Mass Spectrometry, vol. 36, no. 2, pp. 195–203, 2001
  76. Perspectives on the use of electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry for short tandem repeat genotyping in the post-genome era
    Journal of Mass Spectrometry, vol. 36, no. 6, pp. 589–606, 2001
  77. Homogeneous Preparations of 3'-Phosphoglycolate-Terminated Oligodeoxynucleotides from Bleomycin-Treated DNA as Verified by Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
    Analytical Biochemistry, vol. 289, no. 2, pp. 274–280, 2001
  78. Analytical Chemistry, vol. 73, no. 6, pp. 1247–1251, 2001
  79. Analytical Chemistry, vol. 73, no. 14, pp. 3305–3311, 2001
  80. Analytical Chemistry, vol. 73, no. 18, pp. 4514–4521, 2001
  81. Complete sequencing of mono–deprotonated peptide nucleic acids by sustained off–resonance irradiation collision–induced dissociation
    Journal of the American Society for Mass Spectrometry, vol. 12, no. 7, pp. 805–809, 2001
  82. The Public Library, Social Exclusion and the Information Society in the United Kingdom
    Libri, vol. 51, no. 4, pp. 183–194, 2001
  83. Preparation of single-stranded PCR products for electrospray ionization mass spectrometry using the DNA repair enzyme lambda exonuclease
    The Analyst, vol. 125, no. 4, pp. 619–626, 2000
  84. An experimental and theoretical study of the gas-phase decomposition of monoprotonated peptide nucleic acids
    Journal of the American Society for Mass Spectrometry, vol. 11, no. 7, pp. 615–625, 2000
  85. A dual electrospray ionization source combined with hexapole accumulation to achieve high mass accuracy of biopolymers in fourier transform ion cyclotron resonance mass spectrometry
    Journal of the American Society for Mass Spectrometry, vol. 11, no. 10, pp. 876–883, 2000
  86. Hydropathic influences on the quantification of equine heart cytochromec using relative ion abundance measurements by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry
    Journal of Mass Spectrometry, vol. 34, no. 10, pp. 1055–1062, 1999
  87. Quantification of singly charged biomolecules by electrospray ionization fourier transform ion cyclotron resonance mass spectrometry utilizing an internal standard
    Rapid Communications in Mass Spectrometry, vol. 13, no. 3, pp. 164–171, 1999
  88. Characterization of a microdialysis approach to prepare polymerase chain reaction products for electrospray ionization mass spectrometry using on-line ultraviolet absorbance measurements and inductively coupled plasma-atomic emission spectroscopy
    Rapid Communications in Mass Spectrometry, vol. 13, no. 5, pp. 323–330, 1999
  89. Accurate characterization of the tyrosine hydroxylase forensic allele 9.3 through development of electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry
    Rapid Communications in Mass Spectrometry, vol. 13, no. 10, pp. 954–962, 1999
  90. Precise mass measurement of a double-stranded 500 base-pair (309 kDa) polymerase chain reaction product by negative ion electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry
    Rapid Communications in Mass Spectrometry, vol. 13, no. 12, pp. 1201–1204, 1999
  91. Biochemistry, vol. 38, no. 45, pp. 14731–14737, 1999
  92. Analytical Chemistry, vol. 70, no. 6, pp. 1203–1207, 1998
  93. Nanoelectrospray mass spectrometry using non-metalized, tapered (50 ? 10 µm) fused-silica capillaries
    Rapid Communications in Mass Spectrometry, vol. 12, no. 8, pp. 443–448, 1998
  94. Comprehensive nomenclature for the fragment ions produced from collisional activation of peptide nucleic acids
    Rapid Communications in Mass Spectrometry, vol. 12, no. 12, pp. 759–762, 1998
  95. Improving the Microdialysis Procedure for Electrospray Ionization Mass Spectrometry of Biological Samples
    Journal of Mass Spectrometry, vol. 32, no. 4, pp. 425–431, 1997
  96. Application of sequential paired covariance to liquid chromatography-mass spectrometry data enhancements in both the signal-to-noise ratio and the resolution of analyte peaks in the chromatogram
    Journal of Chromatography A, vol. 771, no. 1-2, pp. 1–7, 1997
  97. Analytical Chemistry, vol. 69, no. 8, pp. 1543–1549, 1997
  98. Organometallics, vol. 16, no. 14, pp. 3094–3096, 1997
  99. Journal of the American Chemical Society, vol. 119, no. 22, pp. 5163–5168, 1997
  100. Journal of the American Chemical Society, vol. 119, no. 48, pp. 11611–11619, 1997
  101. Design and Self-Assembly of Nanoscale Organoplatinum Macrocycles
    Journal of the American Chemical Society, vol. 118, no. 36, pp. 8731–8732, 1996
  102. Important Aspects Concerning the Quantification of Biomolecules by Time-of-Flight Secondary-Ion Mass Spectrometry
    Applied Spectroscopy, vol. 50, no. 2, pp. 161–166, 1996
  103. Analytical Chemistry, vol. 68, no. 21, pp. 3705–3712, 1996
  104. A Quantitative Study ofin vitroHepatic Metabolism of Tacrolimus (FK506) Using Secondary Ion and Matrix-assisted Laser Desorption/Ionization Mass Spectrometry
    Rapid Communications in Mass Spectrometry, vol. 10, no. 10, pp. 1215–1218, 1996
  105. Direct quantification of cocaine in urine by time-of-flight mass spectrometry
    Fresenius' Journal of Analytical Chemistry, vol. 354, no. 1, pp. 103–110, 1996
  106. Enhancement of ion intensity in time-of-flight secondary-ionization mass spectrometry
    Journal of the American Society for Mass Spectrometry, vol. 7, no. 5, pp. 467–472, 1996
  107. Charge-State Reduction with Improved Signal Intensity of Oligonucleotides in Electrospray Ionization Mass Spectrometry
    Journal of the American Society for Mass Spectrometry, vol. 7, no. 8, pp. 697–706, 1996
  108. Application of secondary ion and matrix-assisted laser desorption-ionization time-of-flight mass spectrometry for the quantitative analysis of biological molecules
    Mass Spectrometry Reviews, vol. 14, no. 6, pp. 383–429, 1995
  109. Simultaneous quantification of cyclosporin A and its major metabolites by time-of-flight secondary-ion mass spectrometry and matrix-assisted laser desorption/ionization mass spectrometry utilizing data analysis techniques: Comparison with high-performance liquid chromatography
    Journal of Mass Spectrometry, vol. 30, no. 10, pp. 1469–1479, 1995
  110. Application of Sequential Paired Covariance to Capillary Electrophoresis Electrospray Ionization Time-of-Flight Mass Spectrometry: Unraveling the Signal from the Noise in the Electropherogram
    Analytical Chemistry, vol. 67, no. 23, pp. 4371–4375, 1995
  111. Quantitative Measurement of Cyclosporin A in Blood by Time-of-Flight Mass Spectrometry
    Analytical Chemistry, vol. 66, no. 14, pp. 2362–2368, 1994
  112. Journal of Physical Chemistry, vol. 98, no. 44, pp. 11570–11575, 1994