David Muddiman
David Muddiman is currently a Professor of Chemistry and Director of the W. M. Keck FT-ICR Mass Spectrometry Laboratory at North Carolina State University in Raleigh, NC. Prior to moving his research group to NC State, David was a Professor of Biochemistry and Director of the Mayo Proteomics Research Center at the Mayo Clinic College of Medicine in Rochester, Minn. David was an Associate Professor of Chemistry at Virginia Commonwealth University where he began his academic career as an Assistant Professor in 1997. David was born in Long Beach, Calif, in 1967, but spent most of his formidable years in a small town in Pennsylvania. David received his B.S. degree in chemistry from Gannon University, Erie, Pa, in 1990 and his Ph.D. degree in analytical chemistry from the University of Pittsburgh in 1995 under the auspices of David M. Hercules. He then was a Postdoctoral Fellow at Pacific Northwest National Laboratory in the Environmental Molecular Sciences Laboratory working with Richard D. Smith from 1995 to 1997. David has served on over 25 NIH study sections since 1999 and reviews for over 30 scientific journals. He has been a Guest Editor for Analytical and Bioanalytical Chemistry, Mass Spectrometry Reviews, and the Journal of the American Society for Mass Spectrometry. He currently serves on the Editorial Advisory Board of Mass Spectrometry Reviews, Journal of Proteome Research, Rapid Communications in Mass Spectrometry, and the Journal of the American Society for Mass Spectrometry. He also serves on the advisory board of the NHMFL, Florida State University, and the Yale Neuroproteomics Center. His group has presented over 200 invited lectures and presentations at national and international meetings, has published over 110 peer-reviewed papers, and has one US patent. He is the recipient of the 2004 ACS Arthur F. Findeis Award, the 1999 American Society for Mass Spectrometry Research Award, and the Safford Award, University of Pittsburgh, for Excellence in Teaching.
Biography Updated on 8 January 2008
Personal Home Page
http://www.ncsu.edu/chemistry/facultyPages/WMKeck_FTICR.html
Articles in Scholarly Journals [Incomplete List]
- Differential protein expression in male and female human lumbar cerebrospinal fluid using iTRAQ reagents after abundant protein depletion
PROTEOMICS, vol. 7, no. 20, pp. 3726–3734, 2007 - Effect of matrix crystal structure on ion abundance of carbohydrates by matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry
Rapid Communications in Mass Spectrometry, vol. 21, no. 5, pp. 807–811, 2007 - Direct characterization of intact polypeptides by matrix-assisted laser desorption electrospray ionization quadrupole Fourier transform ion cyclotron resonance mass spectrometry
Rapid Communications in Mass Spectrometry, vol. 21, no. 7, pp. 1150–1154, 2007 - Understanding the influence of post-excite radius and axial confinement on quantitative proteomic measurements using Fourier transform ion cyclotron resonance mass spectrometry
Rapid Communications in Mass Spectrometry, vol. 21, no. 7, pp. 1196–1204, 2007 - Quantitative comparison of a flared and a standard heated metal capillary inlet with a voltage-assisted air amplifier on an electrospray ionization linear ion trap mass spectrometer
Rapid Communications in Mass Spectrometry, vol. 21, no. 19, pp. 3207–3212, 2007 - Sub Parts-Per-Million Mass Measurement Accuracy of Intact Proteins and Product Ions Achieved Using a Dual Electrospray Ionization Quadrupole Fourier Transform Ion Cyclotron Resonance Mass Spectrometer
Journal of the American Society for Mass Spectrometry, vol. 18, no. 1, pp. 1–7, 2007 - Detection of Attomole Amounts of Analyte by Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) Determined Using Fluorescence Spectroscopy
Journal of the American Society for Mass Spectrometry, vol. 18, no. 6, pp. 1093–1096, 2007 - Remote Mass Spectrometric Sampling of Electrospray- and Desorption Electrospray-Generated Ions Using an Air Ejector
Journal of the American Society for Mass Spectrometry, vol. 18, no. 10, pp. 1844–1847, 2007 - Probing the Mechanisms of an Air Amplifier Using a LTQ-FT-ICR-MS and Fluorescence Spectroscopy
Journal of the American Society for Mass Spectrometry, vol. 18, no. 11, pp. 1909–1913, 2007 - Parts-Per-Billion Mass Measurement Accuracy Achieved through the Combination of Multiple Linear Regression and Automatic Gain Control in a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer
Analytical Chemistry, vol. 79, no. 13, pp. 5058–5063, 2007 - Achieving Augmented Limits of Detection for Peptides with Hydrophobic Alkyl Tags
Analytical Chemistry, vol. 79, no. 11, pp. 3989–3995, 2007 - Carbohydrate Analysis by Desorption Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
Analytical Chemistry, vol. 79, no. 22, pp. 8812–8815, 2007 - Dual Electrospray Ion Source for Electron-Transfer Dissociation on a Hybrid Linear Ion Trap-Orbitrap Mass Spectrometer
Analytical Chemistry, vol. 79, no. 20, pp. 7916–7919, 2007 - Coordination-Driven Self-Assembly of Metallodendrimers Possessing Well-Defined and Controllable Cavities as Cores
Journal of the American Chemical Society, vol. 129, no. 7, pp. 2120–2129, 2007 - A Highly Efficient Approach to the Self-Assembly of Hexagonal Cavity-Cored Tris[2]pseudorotaxanes from Several Components via Multiple Noncovalent Interactions
Journal of the American Chemical Society, vol. 129, no. 46, pp. 14187–14189, 2007 - Details of the Structure Determination of the Sulfated Steroids PSDS and PADS: New Components of the Sea Lamprey (Petromyzon marinus) Migratory Pheromone
The Journal of Organic Chemistry, vol. 72, no. 20, pp. 7544–7550, 2007 - Epithelial Ovarian Cancer: Disease Etiology, Treatment, Detection, and Investigational Gene, Metabolite, and Protein Biomarkers
Journal of Proteome Research, vol. 6, no. 8, pp. 2936–2962, 2007 - Secreted Proteome Profiling in Human RPE Cell Cultures Derived from Donors with Age Related Macular Degeneration and Age Matched Healthy Donors
Journal of Proteome Research, vol. 6, no. 4, pp. 1615–1615, 2007 - Journal of Proteome Research, vol. 5, no. 2, pp. 370–377, 2006
- A Method for Automatically Interpreting Mass Spectra of 18O-Labeled Isotopic Clusters
Molecular & Cellular Proteomics, vol. 6, no. 2, pp. 305–318, 2006 - Journal of the American Chemical Society, vol. 128, no. 31, pp. 10014–10015, 2006
- The Journal of Organic Chemistry, vol. 71, no. 17, pp. 6644–6647, 2006
- Biochemistry, vol. 45, no. 9, pp. 2852–2861, 2006
- Generation and Detection of Multiply-Charged Peptides and Proteins by Matrix-Assisted Laser Desorption Electrospray Ionization (MALDESI) Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
Journal of the American Society for Mass Spectrometry, vol. 17, no. 12, pp. 1712–1716, 2006 - Direct high-resolution peptide and protein analysis by desorption electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry
Rapid Communications in Mass Spectrometry, vol. 20, no. 22, pp. 3409–3411, 2006 - Accessible proteomics space and its implications for peak capacity for zero-, one- and two-dimensional separations coupled with FT-ICR and TOF mass spectrometry
Journal of Mass Spectrometry, vol. 41, no. 3, pp. 281–288, 2006 - Deja Vu All Over Again: Skin Cap Still Contains a High-Potency Glucocorticosteroid
Archives of Dermatology, vol. 141, no. 6, pp. 801–803, 2005 - Effect of post-excitation radius on ion abundance, mass measurement accuracy, and isotopic distributions in Fourier transform ion cyclotron resonance mass spectrometry
Rapid Communications in Mass Spectrometry, vol. 19, no. 7, pp. 915–918, 2005 - Normalization of relative peptide ratios derived from in-gel digests: applications to protein variant analysis at the peptide level
Rapid Communications in Mass Spectrometry, vol. 19, no. 19, pp. 2871–2877, 2005 - Leveling Response Factors in the Electrospray Ionization Process Using a Heated Capillary Interface
Journal of the American Society for Mass Spectrometry, vol. 16, no. 5, pp. 772–778, 2005 - Accurate Mass Precursor Ion Data and Tandem Mass Spectrometry Identify a Class I Human Leukocyte Antigen A*0201–Presented Peptide Originating from Vaccinia Virus
Journal of the American Society for Mass Spectrometry, vol. 16, no. 11, pp. 1812–1817, 2005 - Protein expression profiling of CLL B cells using replicate off-line strong cation exchange chromatography and LC–MS/MS
Journal of Chromatography B, vol. 819, no. 1, pp. 33–39, 2005 - Derivatives of pentamidine designed to target the lipophosphoglycan
Tetrahedron Letters, vol. 46, no. 4, pp. 695–698, 2005 - Analytical Chemistry, vol. 77, no. 8, pp. 2406–2414, 2005
- Analytical Chemistry, vol. 77, no. 19, pp. 6174–6183, 2005
- Journal of the American Chemical Society, vol. 127, no. 34, pp. 12131–12139, 2005
- Journal of Proteome Research, vol. 4, no. 3, pp. 837–845, 2005
- Journal of Proteome Research, vol. 4, no. 2, pp. 424–434, 2005
- A new history of ASLIB, 1924-1950
Journal of Documentation, vol. 61, no. 3, pp. 402–428, 2005 - Primary Trabecular Meshwork Cells Incubated in Human Aqueous Humor Differ from Cells Incubated in Serum Supplements
Investigative Ophthalmology & Visual Science, vol. 46, no. 8, pp. 2848–2856, 2005 - Journal of Proteome Research, vol. 4, no. 4, pp. 1310–1317, 2005
- Journal of Proteome Research, vol. 4, no. 6, pp. 2243–2249, 2005
- Quantitative mass spectral evidence for the absence of circulating brain natriuretic peptide (BNP-32) in severe human heart failure
Proceedings of the National Academy of Sciences, vol. 102, no. 48, pp. 17442–17447, 2005 - Nucleic Acid Analysis by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry at the Beginning of the Twenty-First Century
Current Pharmaceutical Design, vol. 11, no. 20, pp. 2593–2613, 2005 - Identification and Characterization of Novel, Naturally Processed Measles Virus Class II HLA-DRB1 Peptides
Journal of Virology, vol. 78, no. 1, pp. 42–51, 2004 - Androgens Negatively Regulate Forkhead Transcription Factor FKHR (FOXO1) through a Proteolytic Mechanism in Prostate Cancer Cells
Journal of Biological Chemistry, vol. 279, no. 14, pp. 13866–13877, 2004 - Journal of Proteome Research, vol. 3, no. 3, pp. 658–661, 2004
- Identification of Transthyretin Variants by Sequential Proteomic and Genomic Analysis
Clinical Chemistry, vol. 50, no. 9, pp. 1544–1552, 2004 - Detection of Genetic Variants of Transthyretin by Liquid Chromatography-Dual Electrospray Ionization Fourier-Transform Ion-Cyclotron-Resonance Mass Spectrometry
Clinical Chemistry, vol. 50, no. 9, pp. 1535–1543, 2004 - Journal of Proteome Research, vol. 3, no. 3, pp. 644–652, 2004
- Analytical Chemistry, vol. 76, no. 14, pp. 4118–4122, 2004
- Analytical Chemistry, vol. 76, no. 17, pp. 5097–5103, 2004
- Informed use of proteolytic inhibitors in biomarker discovery
Rapid Communications in Mass Spectrometry, vol. 18, no. 9, pp. 1001–1002, 2004 - Utility of accurate monoisotopic mass measurements to confidently identify lambda exonuclease generated single-stranded amplicons containing 7-deaza analogs by electrospray ionization FT-ICR mass spectrometry
International Journal of Mass Spectrometry, vol. 234, no. 1-3, pp. 79–87, 2004 - Determination of the relative energies of activation for the dissociation of aromatic versus aliphatic phosphopeptides by ESI-FTICR-MS and IRMPD
Journal of the American Society for Mass Spectrometry, vol. 15, no. 1, pp. 121–127, 2004 - A method for calculating 16o/18o peptide ion ratios for the relative quantification of proteomes
Journal of the American Society for Mass Spectrometry, vol. 15, no. 4, pp. 437–445, 2004 - Mass spectral determination of skeletal/cardiac actin isoform ratios in cardiac muscle
Rapid Communications in Mass Spectrometry, vol. 17, no. 13, pp. 1467–1471, 2003 - Determination of a correction to improve mass measurement accuracy of isotopically unresolved polymerase chain reaction amplicons by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry
Rapid Communications in Mass Spectrometry, vol. 17, no. 15, pp. 1714–1722, 2003 - Enzymatic strategies for the characterization of nucleic acids by electrospray ionization mass spectrometry
Rapid Communications in Mass Spectrometry, vol. 17, no. 24, pp. 2699–2706, 2003 - Advantages of thermococcus kodakaraenis (KOD) DNA Polymerase for PCR-mass spectrometry based analyses
Journal of the American Society for Mass Spectrometry, vol. 14, no. 6, pp. 601–604, 2003 - Analytical Chemistry, vol. 75, no. 6, pp. 1331–1339, 2003
- Analytical Chemistry, vol. 75, no. 14, pp. 3411–3418, 2003
- 1H NMR and electrospray mass spectrometry of the mono-ionized bis(2,2'-bis(4,5-dimethylimidazole)chloronitrosylruthenium(II) complex ([Ru(NO)Cl(LH2)2]+, LH2=2,2'-bis(4,5-dimethylimidazole)
Inorganica Chimica Acta, vol. 343, pp. 317–328, 2003 - Naturally processed measles virus peptide eluted from class II HLA-DRB1*03 recognized by T lymphocytes from human blood
Virology, vol. 312, no. 2, pp. 495–506, 2003 - Journal of the American Chemical Society, vol. 125, no. 32, pp. 9647–9652, 2003
- Red information scientist: the information career of J.D. Bernal
Journal of Documentation, vol. 59, no. 4, pp. 387–409, 2003 - Journal of the American Chemical Society, vol. 124, no. 23, pp. 6546–6547, 2002
- CEPH family 1362 STR database: an online resource for characterization of PCR products using electrospray ionization mass spectrometry
Journal of the American Society for Mass Spectrometry, vol. 13, no. 1, pp. 89–90, 2002 - Solution composition and thermal denaturation for the production of single-stranded PCR amplicons: piperidine-induced destabilization of the DNA duplex?
Journal of the American Society for Mass Spectrometry, vol. 13, no. 3, pp. 232–240, 2002 - Evaluation of sample preparation techniques for mass measurements of PCR products using ESI-FT-ICR mass spectrometry
Journal of the American Society for Mass Spectrometry, vol. 13, no. 4, pp. 338–344, 2002 - Tailoring the gas-phase dissociation and determining the relative energy of activation for dissociation of 7-deaza purine modified oligonucleotides containing a repeating motif
International Journal of Mass Spectrometry, vol. 219, no. 1, pp. 139–150, 2002 - Dual-micro-ESI source for precise mass determination on a quadrupole time-of-flight mass spectrometer for genomic and proteomic applications
Analytical and Bioanalytical Chemistry, vol. 373, no. 7, pp. 538–546, 2002 - In celebration of the 70th birthday of Dr David M. Hercules
Analytical and Bioanalytical Chemistry, vol. 373, no. 7, pp. 517–518, 2002 - Genotyping short tandem repeats using flow injection and electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry
Rapid Communications in Mass Spectrometry, vol. 15, no. 5, pp. 348–350, 2001 - Impact of ion cloud densities on the measurement of relative ion abundances in Fourier transform ion cyclotron resonance mass spectrometry: experimental observations of coulombically induced cyclotron radius perturbations and ion cloud dephasing rates
Journal of Mass Spectrometry, vol. 36, no. 2, pp. 195–203, 2001 - Perspectives on the use of electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry for short tandem repeat genotyping in the post-genome era
Journal of Mass Spectrometry, vol. 36, no. 6, pp. 589–606, 2001 - Homogeneous Preparations of 3'-Phosphoglycolate-Terminated Oligodeoxynucleotides from Bleomycin-Treated DNA as Verified by Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
Analytical Biochemistry, vol. 289, no. 2, pp. 274–280, 2001 - Analytical Chemistry, vol. 73, no. 6, pp. 1247–1251, 2001
- Analytical Chemistry, vol. 73, no. 14, pp. 3305–3311, 2001
- Analytical Chemistry, vol. 73, no. 18, pp. 4514–4521, 2001
- Complete sequencing of mono–deprotonated peptide nucleic acids by sustained off–resonance irradiation collision–induced dissociation
Journal of the American Society for Mass Spectrometry, vol. 12, no. 7, pp. 805–809, 2001 - The Public Library, Social Exclusion and the Information Society in the United Kingdom
Libri, vol. 51, no. 4, pp. 183–194, 2001 - Preparation of single-stranded PCR products for electrospray ionization mass spectrometry using the DNA repair enzyme lambda exonuclease
The Analyst, vol. 125, no. 4, pp. 619–626, 2000 - An experimental and theoretical study of the gas-phase decomposition of monoprotonated peptide nucleic acids
Journal of the American Society for Mass Spectrometry, vol. 11, no. 7, pp. 615–625, 2000 - A dual electrospray ionization source combined with hexapole accumulation to achieve high mass accuracy of biopolymers in fourier transform ion cyclotron resonance mass spectrometry
Journal of the American Society for Mass Spectrometry, vol. 11, no. 10, pp. 876–883, 2000 - Hydropathic influences on the quantification of equine heart cytochromec using relative ion abundance measurements by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry
Journal of Mass Spectrometry, vol. 34, no. 10, pp. 1055–1062, 1999 - Quantification of singly charged biomolecules by electrospray ionization fourier transform ion cyclotron resonance mass spectrometry utilizing an internal standard
Rapid Communications in Mass Spectrometry, vol. 13, no. 3, pp. 164–171, 1999 - Characterization of a microdialysis approach to prepare polymerase chain reaction products for electrospray ionization mass spectrometry using on-line ultraviolet absorbance measurements and inductively coupled plasma-atomic emission spectroscopy
Rapid Communications in Mass Spectrometry, vol. 13, no. 5, pp. 323–330, 1999 - Accurate characterization of the tyrosine hydroxylase forensic allele 9.3 through development of electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry
Rapid Communications in Mass Spectrometry, vol. 13, no. 10, pp. 954–962, 1999 - Precise mass measurement of a double-stranded 500 base-pair (309 kDa) polymerase chain reaction product by negative ion electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry
Rapid Communications in Mass Spectrometry, vol. 13, no. 12, pp. 1201–1204, 1999 - Biochemistry, vol. 38, no. 45, pp. 14731–14737, 1999
- Analytical Chemistry, vol. 70, no. 6, pp. 1203–1207, 1998
- Nanoelectrospray mass spectrometry using non-metalized, tapered (50 ? 10 µm) fused-silica capillaries
Rapid Communications in Mass Spectrometry, vol. 12, no. 8, pp. 443–448, 1998 - Comprehensive nomenclature for the fragment ions produced from collisional activation of peptide nucleic acids
Rapid Communications in Mass Spectrometry, vol. 12, no. 12, pp. 759–762, 1998 - Improving the Microdialysis Procedure for Electrospray Ionization Mass Spectrometry of Biological Samples
Journal of Mass Spectrometry, vol. 32, no. 4, pp. 425–431, 1997 - Application of sequential paired covariance to liquid chromatography-mass spectrometry data enhancements in both the signal-to-noise ratio and the resolution of analyte peaks in the chromatogram
Journal of Chromatography A, vol. 771, no. 1-2, pp. 1–7, 1997 - Analytical Chemistry, vol. 69, no. 8, pp. 1543–1549, 1997
- Organometallics, vol. 16, no. 14, pp. 3094–3096, 1997
- Journal of the American Chemical Society, vol. 119, no. 22, pp. 5163–5168, 1997
- Journal of the American Chemical Society, vol. 119, no. 48, pp. 11611–11619, 1997
- Design and Self-Assembly of Nanoscale Organoplatinum Macrocycles
Journal of the American Chemical Society, vol. 118, no. 36, pp. 8731–8732, 1996 - Important Aspects Concerning the Quantification of Biomolecules by Time-of-Flight Secondary-Ion Mass Spectrometry
Applied Spectroscopy, vol. 50, no. 2, pp. 161–166, 1996 - Analytical Chemistry, vol. 68, no. 21, pp. 3705–3712, 1996
- A Quantitative Study ofin vitroHepatic Metabolism of Tacrolimus (FK506) Using Secondary Ion and Matrix-assisted Laser Desorption/Ionization Mass Spectrometry
Rapid Communications in Mass Spectrometry, vol. 10, no. 10, pp. 1215–1218, 1996 - Direct quantification of cocaine in urine by time-of-flight mass spectrometry
Fresenius' Journal of Analytical Chemistry, vol. 354, no. 1, pp. 103–110, 1996 - Enhancement of ion intensity in time-of-flight secondary-ionization mass spectrometry
Journal of the American Society for Mass Spectrometry, vol. 7, no. 5, pp. 467–472, 1996 - Charge-State Reduction with Improved Signal Intensity of Oligonucleotides in Electrospray Ionization Mass Spectrometry
Journal of the American Society for Mass Spectrometry, vol. 7, no. 8, pp. 697–706, 1996 - Application of secondary ion and matrix-assisted laser desorption-ionization time-of-flight mass spectrometry for the quantitative analysis of biological molecules
Mass Spectrometry Reviews, vol. 14, no. 6, pp. 383–429, 1995 - Simultaneous quantification of cyclosporin A and its major metabolites by time-of-flight secondary-ion mass spectrometry and matrix-assisted laser desorption/ionization mass spectrometry utilizing data analysis techniques: Comparison with high-performance liquid chromatography
Journal of Mass Spectrometry, vol. 30, no. 10, pp. 1469–1479, 1995 - Application of Sequential Paired Covariance to Capillary Electrophoresis Electrospray Ionization Time-of-Flight Mass Spectrometry: Unraveling the Signal from the Noise in the Electropherogram
Analytical Chemistry, vol. 67, no. 23, pp. 4371–4375, 1995 - Quantitative Measurement of Cyclosporin A in Blood by Time-of-Flight Mass Spectrometry
Analytical Chemistry, vol. 66, no. 14, pp. 2362–2368, 1994 - Journal of Physical Chemistry, vol. 98, no. 44, pp. 11570–11575, 1994