The research interests are focuses on translational research depicting the role of oxidative stress in metabolic and cardiovascular diseases. Research interest is focused to plant polyphenols as nutrient and potential therapeutic molecules in order to correct metabolic and cardiovascular disorders with special interest on its target that we have recently discovered - the alpha isoform of the oestrogen receptor. On fundamental basis, we test the hypothesis that natural polyphenols prevent the cardiovascular and metabolic consequences in terms of cardiovascular structural and functional remodeling, endothelial dysfunction and adipocyte metabolism. The mechanism of action of these compounds on both molecular and integrated basis is determined. On clinical studies the advanced hypothesis is studied that polyphenols could reverse endothelial and metabolic dysfunctions in patients with metabolic syndrome and obstructive sleep apnea-hypopnea syndrome. With regard to metabolic diseases, the main objective is to better understand the molecular and cellular mechanisms involved metabolic syndrome, obesity and obstructive sleep apnea- in order to propose double approaches including therapeutic and nutritional interventions. The overall aims are focused to determination of the interplay between circulating microparticles (MPs, small vesicles released upon cell stimulation) with monocytes/macrophages, adipocytes as well as cardiac, endothelial and vascular smooth muscle cells, and to assess their contribution to the cardiometabolic consequences of metabolic syndrome.
Biography Updated on 23 June 2013