Hyang-Sook Hoe received her Ph.D. degree from Sungkyunkwan University, Seoul, Suwon, South Korea, in 2002. She is serving as an Assistant Professor at Georgetown University, Washington, DC, USA, and has been studying Alzheimer's disease since 2003. Hoe is serving as an Ad Hoc Reviewer for the NIH Synapse, Cytoskeleton, and Trafficking (SYN) study section as well as for the Alzheimer's association private foundation grant. Hoe's research focuses on ApoE (known to be a high-risk factor for Alzheimer's disease), APP and ApoEr2 signaling pathways, and the mechanism by which the ApoE4 allele affects AD disease. Building on previous research findings that several adaptor proteins affect APP processing and Abeta production, Hoe is investigating the role of ligands and their functional effects, including neurite outgrowth, synapse formation, and spine formation. Evidence indicates that ligands play a key role in AD pathology and suggest a molecular basis for the reversal of memory loss which could lead to new therapeutic approaches to treat the disease.
Biography Updated on 4 April 2012