A-Min Huang got the Ph.D. degree in life sciences from the National Defense Medical Center, Taipei, Taiwan, in 1997. Huang’s Ph.D. work was on the analysis of genes related to memory formation. One of the genes found is integrin-associated protein (IAP). Increase of IAP mRNA expression in the hippocampus is associated with memory formation of passive avoidance learning in rats. While studying IAP expression during learning, it was found that nuclear respiratory factor 1 (NRF-1) is a critical transcription factor in the regulation of IAP gene promoter. Huang is currently an Associate Professor at the Department of Physiology, College of Medicine, the National Cheng Kung University, Tainan, Taiwan. Huang’s areas of expertise are the neuronal differentiation, neuroblastoma cell biology, and cerebellum development. Huang’s current research interests in laboratory are in three aspects. First, he aimed to understand the mechanisms of NRF-1-regulated neurite outgrowth in neuroblastoma cells and primary cultured neurons. Using genome-wide analysis of the NRF-1 binding sites, he found that several categories of novel genes, annotated or hypothetic, are regulated by NRF-1 and mediate its function in neurite outgrowth. Second, he focuses on the roles of integrin-associated protein (IAP) in neuronal differentiation and proliferation. Upregulation of IAP enhances neurite outgrowth in neuroblastoma cells. However, downregulation of IAP increases medulloblastoma cell proliferation, colony formation, and tumor growth. Third, we have been investigating the roles of IAP in cerebellum development. Upregulation of IAP increases granular cell differentiation and migration. However, IAP knockout mice showed abnormality in granular cell proliferation, migration, and cerebellar structure.
Biography Updated on 27 August 2012