Patrizia Mecocci is Professor of cerontology and geriatrics at the University of Perugia, Perugia, Italy, directing the Neurochemistry Laboratory of the institute as well as the Center of Brain Aging and Dementias in the Elderly of the Geriatric Clinic-Monteluce Hospital in Perugia, Italy. She is a member of the Editorial Board of the journal "Brain Aging" . She has a long-standing experience in studying the role of oxidative stress and of nutritional factors in aging (with a peculiar interest in centenarians) in some age-related diseases such as cognitive decline and dementias as well as in pathologies more frequently observed in old age, such as chronic heart failure, diabetes or stroke. Her lab is focused on the development of methods to study modification in biomolecules due to attack of reactive oxygen or nitrogen species. Professor Mecocci with her group has shown during these last few years that biochemical alterations due to oxidative stress are well documented not only in CNS but also in the periphery. This could be quite relevant, as peripheral modifications could serve as marker of disease or of efficacy of specific therapies. The activity of Zn, Se and eme dependent enzymes, such as SOD, GPX, and catalase, has been extensively studied in plasma, blood cells, and tissues (for example muscle) in aging and several age-related diseases, and the results were published in peer-reviewed papers.
Biography Updated on 10 January 2011