Steve Homans

Steve Homans received the BA and D.Phil. degrees in biochemistry from the University of Oxford in 1974 and 1978, respectively. From 1988 to 1994, he held a lectureship position at the University of Dundee, and was a Professor of Biophysical Chemistry at the University of St. Andrews from 1994 to 1999. He is currently Professor of structural biology and Dean of the Faculty of Biological Sciences at the University of Leeds. His honors include the Zeneca Award from the Biochemical Society, UK, in 1998, and election to Fellow of the Royal Society of Edinburgh in 1998. His research interests are focussed on the dynamics and thermodynamics of biomolecular recognition processes, and involve high resolution NMR spectroscopy, isothermal titration calorimetry, and molecular modelling.

Biography Updated on 24 October 2007

Personal Home Page

http://www.astbury.leeds.ac.uk/People/staffpage.php?StaffID=SWH

Articles in Scholarly Journals [Incomplete List]

  1. Origin of Heat Capacity Changes in a “Nonclassical” Hydrophobic Interaction
    ChemBioChem, vol. 8, no. 13, pp. 1509–1511, 2007
  2. Evidence of chemical exchange in recombinant Major Urinary Protein and quenching thereof upon pheromone binding
    Journal of Biomolecular NMR, vol. 38, no. 1, pp. 3–9, 2007
  3. Water, water everywhere — except where it matters?
    Drug Discovery Today, vol. 12, no. 13-14, pp. 534–539, 2007
  4. Global Changes in Local Protein Dynamics Reduce the Entropic Cost of Carbohydrate Binding in the Arabinose-binding Protein
    Journal of Molecular Biology, vol. 368, no. 3, pp. 822–832, 2007
  5. A Simple, RNA-Mediated Allosteric Switch Controls the Pathway to Formation of a T=3 Viral Capsid
    Journal of Molecular Biology, vol. 369, no. 2, pp. 541–552, 2007
  6. Thermodynamic Penalty Arising from Burial of a Ligand Polar Group Within a Hydrophobic Pocket of a Protein Receptor
    Journal of Molecular Biology, vol. 362, no. 5, pp. 994–1003, 2006
  7. Contribution of Ligand Desolvation to Binding Thermodynamics in a Ligand–Protein Interaction
    Angewandte Chemie International Edition, vol. 45, no. 38, pp. 6374–6376, 2006
  8. Amyloid formation under physiological conditions proceeds via a native-like folding intermediate
    Nature Structural & Molecular Biology, vol. 13, no. 3, Article ID nsmb1058, 6 pages, 2006
  9. Dissecting the fine details of assembly of a T =3 phage capsid
    Journal of Theoretical Medicine, vol. 6, no. 2, pp. 119–125, 2005
  10. Journal of the American Chemical Society, vol. 127, no. 33, pp. 11827–11834, 2005
  11. Journal of the American Chemical Society, vol. 127, no. 48, pp. 17061–17067, 2005
  12. Probing the Binding Entropy of Ligand-Protein Interactions by NMR
    ChemBioChem, vol. 6, no. 9, pp. 1585–1591, 2005
  13. Effects of Protein–pheromone Complexation on Correlated Chemical Shift Modulations
    Journal of Biomolecular NMR, vol. 33, no. 4, pp. 233–242, 2005
  14. Dynamics in the Unfolded State of ?-microglobulin Studied by NMR
    Journal of Molecular Biology, vol. 346, no. 1, pp. 279–294, 2005
  15. NMR Spectroscopy Tools for Structure-Aided Drug Design
    Angewandte Chemie International Edition, vol. 43, no. 3, pp. 290–300, 2004
  16. Identification of the 5-Methylthiopentosyl Substituent inMycobacterium tuberculosis Lipoarabinomannan
    Angewandte Chemie International Edition, vol. 43, no. 30, pp. 3918–3922, 2004
  17. Journal of the American Chemical Society, vol. 126, no. 4, pp. 1047–1054, 2004
  18. Journal of the American Chemical Society, vol. 126, no. 6, pp. 1675–1681, 2004
  19. Journal of the American Chemical Society, vol. 126, no. 38, pp. 11870–11876, 2004
  20. Letter to the Editor: Backbone Resonance Assignment of the L-Arabinose Binding Protein in Complex with D-Galactose
    Journal of Biomolecular NMR, vol. 28, no. 2, pp. 191–192, 2004
  21. Journal of the American Chemical Society, vol. 125, no. 11, pp. 3284–3294, 2003
  22. Journal of the American Chemical Society, vol. 125, no. 43, pp. 13058–13062, 2003
  23. Journal of the American Chemical Society, vol. 125, no. 51, pp. 15767–15771, 2003
  24. Journal of Biomolecular NMR, vol. 25, no. 1, pp. 63–71, 2003
  25. Structural properties of an amyloid precursor of ß2-microglobulin
    Nature Structural Biology, vol. 9, no. 5, pp. 326–331, 2002
  26. Journal of Biomolecular NMR, vol. 22, no. 1, pp. 21–26, 2002
  27. 5-methylthiopentose: a new substituent on lipoarabinomannan in Mycobacterium tuberculosis
    Journal of Molecular Biology, vol. 316, no. 1, pp. 89–100, 2002
  28. Residual 2H Quadrupolar Couplings in Weakly Aligned Carbohydrates
    Journal of Magnetic Resonance, vol. 151, no. 1, pp. 90–93, 2001
  29. Journal of Biomolecular NMR, vol. 19, no. 3, pp. 255–260, 2001
  30. Journal of the American Chemical Society, vol. 121, no. 11, pp. 2546–2551, 1999
  31. Journal of the American Chemical Society, vol. 121, no. 24, pp. 5815–5816, 1999
  32. Journal of the American Chemical Society, vol. 121, no. 50, pp. 11871–11874, 1999
  33. Journal of Biomolecular NMR, vol. 11, no. 3, pp. 289–294, 1998
  34. New conformational constraints in isotopically (13C) enriched oligosaccharides
    Glycobiology, vol. 8, no. 2, pp. 147–153, 1998
  35. Residual dipolar couplings as new conformational restraints in isotopically 13C-enriched oligosaccharides
    FEBS Letters, vol. 436, no. 1, pp. 128–130, 1998
  36. Chemical synthesis of 13C-labelled ganglioside Gb3 trisaccharide from [U-13C]-D-glucose
    Tetrahedron, vol. 54, no. 32, pp. 9489–9506, 1998
  37. Structure of a glycoconjugate in solution and in complex with an antibody Fv fragment
    Glycobiology, vol. 7, no. 3, pp. 373–381, 1997
  38. Solution structure of the carbohydrate-binding B-subunit homopentamer of verotoxin VT-1 from E. coli
    Nature Structural Biology, vol. 4, no. 3, Article ID nsb0397-190, 3 pages, 1997
  39. Journal of Biomolecular NMR, vol. 9, no. 1, pp. 47–54, 1997
  40. Biochemistry, vol. 35, no. 6, pp. 1954–1964, 1996
  41. Biochemistry, vol. 35, no. 27, pp. 8815–8823, 1996
  42. Three-dimensional structures of gonadotropins
    Molecular and Cellular Endocrinology, vol. 125, no. 1-2, pp. 21–31, 1996
  43. Biochemistry, vol. 34, no. 43, pp. 14131–14137, 1995
  44. Proton Resonance Assignments in Oligosaccharides Containing Multiple Monosaccharide Residues of the Same Type
    Journal of Magnetic Resonance, Series B, vol. 106, no. 1, pp. 10–13, 1995
  45. Solution dynamics of the oligosaccharide moiety of ganglioside GM1: Comparison of solution conformations with the bound state conformation in association with cholera toxin B-pentamer
    Journal of Molecular Recognition, vol. 8, no. 6, pp. 358–362, 1995
  46. A Unique Multifucosylated -3GalNAc[IMAGE]1[IMAGE]4GlcNAc[IMAGE]1[IMAGE]3Gal[IMAGE]1- Motif Constitutes the Repeating Unit of the Complex O-Glycans Derived from the Cercarial Glycocalyx of Schistosoma mansoni
    Journal of Biological Chemistry, vol. 270, no. 29, pp. 17114–17123, 1995
  47. Solution structure and dynamics of a glycoinositol phospholipid (GIPL-6) fromLeishmania major
    Biopolymers, vol. 34, no. 9, pp. 1155–1163, 1994
  48. Biochemistry, vol. 33, no. 32, pp. 9606–9614, 1994
  49. Biochemistry, vol. 32, no. 47, pp. 12715–12724, 1993
  50. Carbohydrates and glycoconjugates Editorial overview
    Current Opinion in Structural Biology, vol. 3, no. 5, pp. 667–668, 1993
  51. Nuclear Magnetic Resonance Study of a Deoxyoligonucleotide Duplex Containing a Three Base Bulge
    Journal of Molecular Biology, vol. 229, no. 1, pp. 173–188, 1993
  52. Biochemistry, vol. 31, no. 3, pp. 654–661, 1992
  53. Evolutionary aspects of GPI metabolism in kinetoplastid parasites
    Cell Biology International Reports, vol. 15, no. 11, pp. 991–1005, 1991
  54. Oligosaccharide conformations: Application of NMR and energy calculations
    Progress in Nuclear Magnetic Resonance Spectroscopy, vol. 22, no. 1, pp. 55–81, 1990
  55. Biochemistry, vol. 29, no. 39, pp. 9110–9118, 1990
  56. Biochemistry, vol. 28, no. 7, pp. 2881–2887, 1989
  57. Complete structure of the glycosyl phosphatidylinositol membrane anchor of rat brain Thy-1 glycoprotein
    Nature, vol. 333, no. 6170, Article ID 333269a0, 3 pages, 1988
  58. Parasite glycoconjugates: towards the exploitation of their structure
    Parasite Immunology, vol. 10, no. 5, pp. 465–479, 1988
  59. The beta1 2-d-xylose and alpha1 3-l-fucose substituted N-linked oligosaccharides from Erythrina cristagalli lectin. Isolation, characterisation and comparison with other legume lectins
    European Journal of Biochemistry, vol. 166, no. 2, pp. 311–320, 1987
  60. A Method for the Rapid Assignment of 1H NMR Spectra of Oligosaccharides Using Homonuclear Hartmann-Hahn Spectroscopy
    Proceedings of the National Academy of Sciences, vol. 84, no. 5, pp. 1202–1205, 1987
  61. Biochemistry, vol. 26, no. 19, pp. 6233–6238, 1987
  62. Biochemistry, vol. 26, no. 20, pp. 6553–6560, 1987
  63. Biochemistry, vol. 26, no. 21, pp. 6571–6578, 1987
  64. Biochemistry, vol. 26, no. 21, pp. 6649–6655, 1987
  65. Biochemistry, vol. 25, no. 20, pp. 6342–6350, 1986
  66. The analysis of coupling networks in a complex oligosaccharide mixture derived from the Fc region of rabbit immunoglobulin G using 1H-1H correlated NMR spectroscopy combined with double quantum NMR spectroscopy
    Biochimica et Biophysica Acta (BBA) - General Subjects, vol. 798, no. 1, pp. 78–83, 1984
  67. Multiple-Step Relayed Correlation Spectroscopy: Sequential Resonance Assignments in Oligosaccharides
    Proceedings of the National Academy of Sciences, vol. 81, no. 20, pp. 6286–6289, 1984
  68. The use of two-dimensional correlated spectroscopy to obtain new assignments in the high-resolution 1H nuclear magnetic resonance spectrum of the biantennary complex oligosaccharide isolated from human serum transferrin by hydrazinolysis
    Biochimica et Biophysica Acta (BBA) - General Subjects, vol. 760, no. 2, pp. 256–261, 1983
  69. Solution conformation of the biantennary N-linked oligosaccharide of human serotransferrin using 1H NMR nuclear Overhauser effect measurements
    FEBS Letters, vol. 150, no. 2, pp. 503–506, 1982