Robert Tanguay

Robert Tanguay is an Associate Professor at the Department of Environmental and Molecular Toxicology, the Director of the Sinnhuber Aquatic Research Laboratory, and the Director of the NIEHS Toxicology Training Grant. He received his Ph.D. degree in biochemistry from the University of California-Riverside (1995) and postdoctoral training in developmental toxicology from the University of Wisconsin-Madison (1996–1999). His group has a long interest in better understanding the mechanism(s) underlying developmental toxicity in response to chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), ethanol, nicotine, and pesticides. He also has a regenerative medicine group that is developing new methods and approaches to discover the molecular pathways that prevent or promote vertebrate tissue regeneration.

Biography Updated on 14 April 2008

Personal Home Page

http://emt.oregonstate.edu/faculty/tanguay.htm

Articles in Scholarly Journals [Incomplete List]

  1. In vivo evaluation of carbon fullerene toxicity using embryonic zebrafish
    Carbon, vol. 45, no. 9, pp. 1891–1898, 2007
  2. Ethanol-dependent toxicity in zebrafish is partially attenuated by antioxidants
    Neurotoxicology and Teratology, vol. 28, no. 4, pp. 497–508, 2006
  3. Aryl Hydrocarbon Receptor Activation Impairs Extracellular Matrix Remodeling during Zebra Fish fin Regeneration
    Toxicological Sciences, vol. 95, no. 1, pp. 215–226, 2006
  4. Dithiocarbamates have a common toxic effect on zebrafish body axis formation
    Toxicology and Applied Pharmacology, vol. 216, no. 1, pp. 55–68, 2006
  5. Muscular contractions in the zebrafish embryo are necessary to reveal thiuram-induced notochord distortions
    Toxicology and Applied Pharmacology, vol. 212, no. 1, pp. 24–34, 2006
  6. Regenerative Growth Is Impacted by TCDD: Gene Expression Analysis Reveals Extracellular Matrix Modulation
    Toxicological Sciences, vol. 92, no. 1, pp. 254–269, 2006
  7. MOLECULAR CLONING, BACULOVIRUS EXPRESSION, AND TISSUE DISTRIBUTION OF THE ZEBRAFISH ALDEHYDE DEHYDROGENASE 2
    Drug Metabolism and Disposition, vol. 33, no. 5, pp. 649–656, 2005
  8. Identification of zebrafish ARNT1 homologs:TCDD toxicity in the developing zebrafish requires ARNT1
    Molecular Pharmacology, 2005
  9. AHR ACTIVATION INHIBITS REGENERATIVE GROWTH
    Molecular Pharmacology, 2005
  10. Histological analysis of acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in zebrafish
    Aquatic Toxicology, vol. 66, no. 1, pp. 25–38, 2004
  11. Ethanol- and acetaldehyde-mediated developmental toxicity in zebrafish
    Neurotoxicology and Teratology, vol. 26, no. 6, pp. 769–781, 2004
  12. Developmental Toxicity of the Dithiocarbamate Pesticide Sodium Metam in Zebrafish
    Toxicological Sciences, vol. 81, no. 2, pp. 390–400, 2004
  13. Effect of heat preconditioning on the uptake and permeability of R123 in brain microvessel endothelial cells during mild heat treatment
    Journal of Pharmaceutical Sciences, vol. 93, no. 4, pp. 896–907, 2004
  14. Two Zebrafish Alcohol Dehydrogenases Share Common Ancestry with Mammalian Class I, II, IV, and V Alcohol Dehydrogenase Genes but Have Distinct Functional Characteristics
    Journal of Biological Chemistry, vol. 279, no. 37, pp. 38303–38312, 2004
  15. Identification of a putative calcium-binding protein as a dioxin-responsive gene in zebrafish and rainbow trout
    Aquatic Toxicology, vol. 63, no. 3, pp. 271–282, 2003
  16. 2,3,7,8-Tetrachlorodibenzo-p-dioxin Inhibits Zebrafish Caudal Fin Regeneration
    Toxicological Sciences, vol. 76, no. 1, pp. 151–161, 2003
  17. The Zebrafish (Danio rerio) Aryl Hydrocarbon Receptor Type 1 Is a Novel Vertebrate Receptor
    Molecular Pharmacology, vol. 62, no. 2, pp. 234–249, 2002
  18. Identification of a Critical Amino Acid in the Aryl Hydrocarbon Receptor
    Journal of Biological Chemistry, vol. 277, no. 15, pp. 13210–13218, 2002
  19. Tissue-Specific Expression of AHR2, ARNT2, and CYP1A in Zebrafish Embryos and Larvae: Effects of Developmental Stage and 2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure
    Toxicological Sciences, vol. 68, no. 2, pp. 403–419, 2002
  20. Developmental and Thermal Regulation of the Maize Heat Shock Protein, HSP101
    PLANT PHYSIOLOGY, vol. 127, no. 3, pp. 777–791, 2001
  21. Heat Shock Protein HSP101 Binds to the Fed-1 Internal Light Regulator y Element and Mediates Its High Translational Activity
    THE PLANT CELL ONLINE, vol. 12, no. 7, pp. 1213–1228, 2000
  22. Identification and expression of alternatively spliced aryl hydrocarbon nuclear translocator 2 (ARNT2) cDNAs from zebrafish with distinct functions
    Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, vol. 1494, no. 1-2, pp. 117–128, 2000
  23. Cloning and characterization of the zebrafish (Danio rerio) aryl hydrocarbon receptor
    Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, vol. 1444, no. 1, pp. 35–48, 1999
  24. Two Forms of Aryl Hydrocarbon Receptor Type 2 in Rainbow Trout (Oncorhynchus mykiss). EVIDENCE FOR DIFFERENTIAL EXPRESSION AND ENHANCER SPECIFICITY
    Journal of Biological Chemistry, vol. 274, no. 21, pp. 15159–15166, 1999
  25. Transactivation Activity of Human, Zebrafish, and Rainbow Trout Aryl Hydrocarbon Receptors Expressed in COS-7 Cells: Greater Insight into Species Differences in Toxic Potency of Polychlorinated Dibenzo-p-dioxin, Dibenzofuran, and Biphenyl Congeners
    Toxicology and Applied Pharmacology, vol. 159, no. 1, pp. 41–51, 1999
  26. Translation initiation factors are differentially regulated in cereals during development and following heat shock
    The Plant Journal, vol. 14, no. 6, pp. 715–722, 1998
  27. Translation Initiation Factors eIF-iso4G and eIF-4B Interact with the Poly(A)-binding Protein and Increase Its RNA Binding Activity
    Journal of Biological Chemistry, vol. 272, no. 26, pp. 16247–16255, 1997
  28. The Phosphorylation State of Translation Initiation Factors Is Regulated Developmentally and following Heat Shock in Wheat
    Journal of Biological Chemistry, vol. 272, no. 2, pp. 1046–1053, 1997
  29. The effect of the length of the 3'-untranslated region on expression in plants
    FEBS Letters, vol. 394, no. 3, pp. 285–288, 1996
  30. Isolation and Characterization of the 102-Kilodalton RNA-binding Protein That Binds to the 5' and 3' Translational Enhancers of Tobacco Mosaic Virus RNA
    Journal of Biological Chemistry, vol. 271, no. 24, pp. 14316–14322, 1996
  31. The tobacco etch viral 5$prime; leader and poly(A) tail are functionally synergistic regulators of translation
    Gene, vol. 165, no. 2, pp. 233–238, 1995
  32. In vivo footprint and methylation analysis by PCR-aided genomic sequencing: comparison of active and inactive X chromosomal DNA at the CpG island and promoter of human PGK-1.
    Genes & Development, vol. 4, no. 8, pp. 1277–1287, 1990