Robert Tanguay
Robert Tanguay is an Associate Professor at the Department of Environmental and Molecular Toxicology, the Director of the Sinnhuber Aquatic Research Laboratory, and the Director of the NIEHS Toxicology Training Grant. He received his Ph.D. degree in biochemistry from the University of California-Riverside (1995) and postdoctoral training in developmental toxicology from the University of Wisconsin-Madison (1996–1999). His group has a long interest in better understanding the mechanism(s) underlying developmental toxicity in response to chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), ethanol, nicotine, and pesticides. He also has a regenerative medicine group that is developing new methods and approaches to discover the molecular pathways that prevent or promote vertebrate tissue regeneration.
Biography Updated on 14 April 2008
Personal Home Page
http://emt.oregonstate.edu/faculty/tanguay.htm
Articles in Scholarly Journals [Incomplete List]
- In vivo evaluation of carbon fullerene toxicity using embryonic zebrafish
Carbon, vol. 45, no. 9, pp. 1891–1898, 2007 - Ethanol-dependent toxicity in zebrafish is partially attenuated by antioxidants
Neurotoxicology and Teratology, vol. 28, no. 4, pp. 497–508, 2006 - Aryl Hydrocarbon Receptor Activation Impairs Extracellular Matrix Remodeling during Zebra Fish fin Regeneration
Toxicological Sciences, vol. 95, no. 1, pp. 215–226, 2006 - Dithiocarbamates have a common toxic effect on zebrafish body axis formation
Toxicology and Applied Pharmacology, vol. 216, no. 1, pp. 55–68, 2006 - Muscular contractions in the zebrafish embryo are necessary to reveal thiuram-induced notochord distortions
Toxicology and Applied Pharmacology, vol. 212, no. 1, pp. 24–34, 2006 - Regenerative Growth Is Impacted by TCDD: Gene Expression Analysis Reveals Extracellular Matrix Modulation
Toxicological Sciences, vol. 92, no. 1, pp. 254–269, 2006 - MOLECULAR CLONING, BACULOVIRUS EXPRESSION, AND TISSUE DISTRIBUTION OF THE ZEBRAFISH ALDEHYDE DEHYDROGENASE 2
Drug Metabolism and Disposition, vol. 33, no. 5, pp. 649–656, 2005 - Identification of zebrafish ARNT1 homologs:TCDD toxicity in the developing zebrafish requires ARNT1
Molecular Pharmacology, 2005 - AHR ACTIVATION INHIBITS REGENERATIVE GROWTH
Molecular Pharmacology, 2005 - Histological analysis of acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in zebrafish
Aquatic Toxicology, vol. 66, no. 1, pp. 25–38, 2004 - Ethanol- and acetaldehyde-mediated developmental toxicity in zebrafish
Neurotoxicology and Teratology, vol. 26, no. 6, pp. 769–781, 2004 - Developmental Toxicity of the Dithiocarbamate Pesticide Sodium Metam in Zebrafish
Toxicological Sciences, vol. 81, no. 2, pp. 390–400, 2004 - Effect of heat preconditioning on the uptake and permeability of R123 in brain microvessel endothelial cells during mild heat treatment
Journal of Pharmaceutical Sciences, vol. 93, no. 4, pp. 896–907, 2004 - Two Zebrafish Alcohol Dehydrogenases Share Common Ancestry with Mammalian Class I, II, IV, and V Alcohol Dehydrogenase Genes but Have Distinct Functional Characteristics
Journal of Biological Chemistry, vol. 279, no. 37, pp. 38303–38312, 2004 - Identification of a putative calcium-binding protein as a dioxin-responsive gene in zebrafish and rainbow trout
Aquatic Toxicology, vol. 63, no. 3, pp. 271–282, 2003 - 2,3,7,8-Tetrachlorodibenzo-p-dioxin Inhibits Zebrafish Caudal Fin Regeneration
Toxicological Sciences, vol. 76, no. 1, pp. 151–161, 2003 - The Zebrafish (Danio rerio) Aryl Hydrocarbon Receptor Type 1 Is a Novel Vertebrate Receptor
Molecular Pharmacology, vol. 62, no. 2, pp. 234–249, 2002 - Identification of a Critical Amino Acid in the Aryl Hydrocarbon Receptor
Journal of Biological Chemistry, vol. 277, no. 15, pp. 13210–13218, 2002 - Tissue-Specific Expression of AHR2, ARNT2, and CYP1A in Zebrafish Embryos and Larvae: Effects of Developmental Stage and 2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure
Toxicological Sciences, vol. 68, no. 2, pp. 403–419, 2002 - Developmental and Thermal Regulation of the Maize Heat Shock Protein, HSP101
PLANT PHYSIOLOGY, vol. 127, no. 3, pp. 777–791, 2001 - Heat Shock Protein HSP101 Binds to the Fed-1 Internal Light Regulator y Element and Mediates Its High Translational Activity
THE PLANT CELL ONLINE, vol. 12, no. 7, pp. 1213–1228, 2000 - Identification and expression of alternatively spliced aryl hydrocarbon nuclear translocator 2 (ARNT2) cDNAs from zebrafish with distinct functions
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, vol. 1494, no. 1-2, pp. 117–128, 2000 - Cloning and characterization of the zebrafish (Danio rerio) aryl hydrocarbon receptor
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, vol. 1444, no. 1, pp. 35–48, 1999 - Two Forms of Aryl Hydrocarbon Receptor Type 2 in Rainbow Trout (Oncorhynchus mykiss). EVIDENCE FOR DIFFERENTIAL EXPRESSION AND ENHANCER SPECIFICITY
Journal of Biological Chemistry, vol. 274, no. 21, pp. 15159–15166, 1999 - Transactivation Activity of Human, Zebrafish, and Rainbow Trout Aryl Hydrocarbon Receptors Expressed in COS-7 Cells: Greater Insight into Species Differences in Toxic Potency of Polychlorinated Dibenzo-p-dioxin, Dibenzofuran, and Biphenyl Congeners
Toxicology and Applied Pharmacology, vol. 159, no. 1, pp. 41–51, 1999 - Translation initiation factors are differentially regulated in cereals during development and following heat shock
The Plant Journal, vol. 14, no. 6, pp. 715–722, 1998 - Translation Initiation Factors eIF-iso4G and eIF-4B Interact with the Poly(A)-binding Protein and Increase Its RNA Binding Activity
Journal of Biological Chemistry, vol. 272, no. 26, pp. 16247–16255, 1997 - The Phosphorylation State of Translation Initiation Factors Is Regulated Developmentally and following Heat Shock in Wheat
Journal of Biological Chemistry, vol. 272, no. 2, pp. 1046–1053, 1997 - The effect of the length of the 3'-untranslated region on expression in plants
FEBS Letters, vol. 394, no. 3, pp. 285–288, 1996 - Isolation and Characterization of the 102-Kilodalton RNA-binding Protein That Binds to the 5' and 3' Translational Enhancers of Tobacco Mosaic Virus RNA
Journal of Biological Chemistry, vol. 271, no. 24, pp. 14316–14322, 1996 - The tobacco etch viral 5$prime; leader and poly(A) tail are functionally synergistic regulators of translation
Gene, vol. 165, no. 2, pp. 233–238, 1995 - In vivo footprint and methylation analysis by PCR-aided genomic sequencing: comparison of active and inactive X chromosomal DNA at the CpG island and promoter of human PGK-1.
Genes & Development, vol. 4, no. 8, pp. 1277–1287, 1990