Uwe-Karsten Hanisch

University of Göttingen, Germany

Uwe Hanisch studied biochemistry at the University of Leipzig (Germany) and received his diploma in 1986. After his PhD period at the Paul-Flechsig-Instute for Brain Research in Leipzig he joined in 1991 the laboratories of Rémi Quirion at the Douglas Hospital Research Centre at the McGill University in Montreal (Canada). From 1993 to 2002 he worked in the group of Helmut Kettenmann at the Max-Delbrück-Center for Molecular Medicine in Berlin (Germany), subsequently having a professorship for biochemistry at the University of Applied Sciences Lausitz. Since 2004, he is a Professor for Experimental Neurobiology at the Institute of Neuropathology at the University of Göttingen (Germany), with a guest professorship at the University of Groningen (The Netherlands) from 2007 to 2009. Previous work related to the expression and effects of cytokines in the CNS, like in the control of neuronal, endocrine and glial activities. Current research interests cover the the role of microglia in CNS injury and diseases, especially mechanisms of their activation and activity control. The function of Toll-like receptors (TLR) in the recognition of infectious agents and damage-induced factors is thereby a major focus. In several projects, especially TLR4 is studied as to the organization of microglial reactive phenotypes and heterogeneous responses upon challenges. His research has been supported also by the Medical Research Council of Canada, the Human Frontier Science Program Organization, the German Research Foundation, the Program of Lower Saxony-Israeli Research Cooperation and the Hertie Foundation.

Biography Updated on 6 February 2011

Scholarly Contributions [Data Provided by scopus]