Lin Ji obtained a Ph.D. degree. Ji serves as a Professor at the Department of Thoracic & Cardiovascular Surgery at the M.D. Anderson Cancer Center, Houston, TX, USA. His current research is focused on understanding the biological functions and molecular mechanisms of novel tumor suppressor genes, especially those recently identified in human chromosome 3p21.3 region, oncogenes, and microRNAs in lung cancer development and treatment responses. His laboratory has also explored anticancer therapeutic applications of these novel tumor suppressor genes and microRNAs by recombinant adenoviral vector, nonviral vector, and nanoparticle-mediated gene transfer and is testing and developing novel small molecule drugs and molecular antagonists to oncogenic targets for lung cancer treatments. His research interests and works also include using and developing high throughput functional genomics and proteomics approaches to identify biomarkers and molecular signatures involved in oncogenic and tumor suppressing signaling pathways and to study transcriptional and posttranscriptional regulation of gene expression, posttranslational modifications of proteins as well as protein-protein interactions in various lung cancer cell lines and preclinical and clinical specimens. His research activities also emphasize understanding the mechanisms of drug resistance and exploring combination treatment strategies for overcoming the drug resistance. Ji has developed various human lung cancer xenograft and transgenic mouse models to understand the biology of lung cancer pathogenesis and to evaluate novel cancer therapeutic strategies and agents. His researches on functional characterization, molecular mechanism studies, and therapeutic applications of candidate 3p21.3 tumor suppressor genes have been exemplary in translation of laboratory studies into clinical trials for lung cancer therapy.
Biography Updated on 17 August 2012