Pablo Pelegrin obtained his Ph.D. degree from University of Murcia, Murcia, Spain, working with developmental immunology in the area of proinflammatory cytokines, with special emphasis on fish interleukin-1. Later on, Pelegrin moved to University of Sheffield, Sheffield, UK to do postdoctoral in Professor Annmarie Surprenant studying the P2X7 receptor-associated signalling to the inflammasome. He identifies pannexin-1 hemichannels as components of P2X7 receptor- associated complex inducing cell permeabilization. Then, he moved with Professor Annmarie Surprenant to the University of Manchester, Manchester, UK, where he explored the processing and release of interleukin-1b by the inflammasome and developed a novel method to study macrophage polarization. He obtained a Lecturer position at University of Sheffield and then he moved back to the University Hospital Virgen de la Arrixaca, Murcia, Spain, as a Principal Investigator. From 2009, Dr. Pelegrin runs a lab of 5 members, and he has obtained national funding from 4 different competitive calls. He serves also as Honorary Lecturer at University of Manchester, UK, and the main focus of his team is to investigate into the role of dangerous signals on the immune system, including the activation of the P2X7 receptor in immune cells by extracellular ATP and its relation to inflammatory diseases.
Biography Updated on 21 January 2015