Pasquale Annunziata is a holder of an M.D. degree. He is an Associate Professor of neurology at the University of Siena, Italy, and is the Head of the Clinical Neuroimmunology Unit at the Medical School Hospital of the University of Siena. He received his Medical degree and specialization in neurology at the University of Naples, Naples, Italy. He spent several time periods as a Guest Researcher at the MRC Developmental Neurobiology Unit, Institute of Neurology, London, UK, and as a Visiting Scientist at the Department of Neurology, University of Chicago, Chicago, Ill, USA. His major research interests and areas of expertise are dealing with humoral and cellular immunology of the immune-mediated neurological disorders including multiple sclerosis and Guillain-Barré syndrome as well as the relationships between retroviruses including HIV-1 and neurological diseases and the association of connective disorders including lupus and Sjogren’s syndrome with neuroimmunological diseases. In the last decade, he has investigated the immune regulation processes of the blood-brain barrier demonstrating the key role of the neurokinins and especially substance P in mediating the breakage of the blood-brain barrier caused by HIV-1 as well as by proinflammatory cytokines and suggesting a new possible pharmacological target in immune-mediated and infectious neurological disorders. He serves as a Reviewer of a number of international journals of clinical neurology and neuroscience as well as of AIDS program of the Italian Ministry of Health and of the national research programs of the Italian Ministry of University as well as of National Multiple Sclerosis Society. His scientific production is published in several international peer-reviewed journals as well as in chapters of international books.
Biography Updated on 7 February 2012