Kazuaki Ishihara

Kazuaki Ishihara is a Professor of chemistry of biological active materials, Department of Biotechnology, Graduate School of Engineering, Nagoya University. His research interests include asymmetric catalysis, biomimetic catalysis induced by artificial enzymes, dehydrative condensation catalysis toward green and sustainable chemistry, and acid-base combination chemistry. He was born in 1963 in Aichi, Japan, and received his Ph.D. degree from Nagoya University in 1991 under the direction of Professor Hisashi Yamamoto. He had worked under Professor Clayton H. Heathcock at the University of California, Berkeley, as a visiting graduate student for three months in 1988. He was a JSPS Fellow under the Japanese Junior Scientists Program from 1989 to 1991. After he completed his postdoctoral studies with Professor E. J. Corey at Harvard University for 15 months beginning in 1991, he returned to Japan and joined Professor Hisashi Yamamoto's group at Nagoya University as an Assistant Professor in 1992, and was made an Associate Professor in 1997. In 2002, he was appointed to his current position as a Full Professor at Nagoya University. He has received the Inoue Research Award for Young Scientists, in 1994, the Chemical Society of Japan Award for Young Chemists, in 1996, the Thieme Chemistry Journal Award, in 2001, the Green & Sustainable Chemistry Award from the Ministry of Education, Culture, Sports, Science and Technology, in 2003, a JSPS Prize, in 2005, a BCSJ Award, in 2005, the 0th International Conference on Cutting-Edge Organic Chemistry in Asia Lectureship Award, in 2006, the Japan/UK GSC Syposium Lectureship, in 2007, and the Japan IBM Science Prize, 2007.

Biography Updated on 25 October 2007

Personal Home Page

http://www.nubio.nagoya-u.ac.jp/nubio4/English/ishihara.htm

Articles in Scholarly Journals [Incomplete List]

  1. Dehydrative Cyclization Catalyzed by the Combination of Molybdenum(VI) Oxides and Benzoic Acids: First Synthesis of the Antitumour Substance BE-70016
    Advanced Synthesis & Catalysis, vol. 349, no. 4-5, pp. 551–555, 2007
  2. Catalytic Synthesis of Peptide-Derived Thiazolines and Oxazolines using Bis(quinolinolato)dioxomolybdenum(VI) Complexes
    Advanced Synthesis & Catalysis, vol. 349, no. 10, pp. 1641–1646, 2007
  3. The Oxorhenium(VII)-Catalyzed Direct Condensation of Phosphoric Acid with an Alcohol
    Angewandte Chemie International Edition, vol. 46, no. 9, pp. 1423–1426, 2007
  4. Unusual Rate Acceleration in Brønsted Acid Catalyzed Dehydration Reactions: Local Hydrophobic Environment in AggregatedN-(2,6-diphenylphenyl)-N-mesitylammonium Pentafluorobenzenesulfonates
    Chemistry – An Asian Journal, vol. 2, no. 4, pp. 477–483, 2007
  5. Kinetic resolution of racemic alcohols catalyzed by minimal artificial acylases derived from l-histidine
    Tetrahedron, vol. 63, no. 27, pp. 6191–6203, 2007
  6. New boron(III)-catalyzed amide and ester condensation reactions
    Tetrahedron, vol. 63, no. 35, pp. 8645–8657, 2007
  7. Enantioselective conjugate addition of dialkylzinc to cyclic enones catalyzed by chiral binaphthyldiamine–copper(I) complexes
    Tetrahedron Letters, vol. 48, no. 49, pp. 8590–8594, 2007
  8. Dimeric scandium(III) and monomeric lanthanide(III) complexes with perfluoropropane-1,3-disulfonates as counter anions for Lewis acid catalysis
    Journal of Organometallic Chemistry, vol. 692, no. 1-3, pp. 569–578, 2007
  9. Rational Design of Minimal Artificial Diels–Alderases Based on the Copper(II) Cation–Aromatic p Attractive Interaction
    Accounts of Chemical Research, vol. 40, no. 10, pp. 1049–1055, 2007
  10. Enantioselective [2 + 2] Cycloaddition of Unactivated Alkenes with a-Acyloxyacroleins Catalyzed by Chiral Organoammonium Salts
    Journal of the American Chemical Society, vol. 129, no. 29, pp. 8930–8931, 2007
  11. Sodium Phenoxide-Phosphine Oxides as Extremely Active Lewis Base Catalysts for the Mukaiyama Aldol Reaction with Ketones
    Organic Letters, vol. 9, no. 22, pp. 4527–4530, 2007
  12. Highly Active Chiral Phosphoramide-Zn(II) Complexes as Conjugate Acid-Base Catalysts for Enantioselective Organozinc Addition to Ketones
    Organic Letters, vol. 9, no. 22, pp. 4535–4538, 2007
  13. Enantioselective halocyclization of polyprenoids induced by nucleophilic phosphoramidites
    Nature, vol. 445, no. 7130, Article ID nature05553, 3 pages, 2007
  14. Direct ester condensation catalyzed by bulky diarylammonium pentafluorobenzenesulfonates
    Nature Protocols, vol. 2, no. 7, Article ID nprot.2007.254, 5 pages, 2007
  15. Bulky phosphazenium cation catalysis for dehydrative condensation of phosphoric acid with alcohols
    Green Chemistry, vol. 9, no. 11, p. 1166, 2007
  16. Design of Highly Functional Small-Molecule Catalysts and Related Reactions Based on Acid-Base Combination Chemistry
    Synlett, vol. 2007, no. 5, pp. 0686–0703, 2007
  17. Perrhenic Acid-Catalyzed Dehydration from Primary Amides, Aldoximes, N-Monoacylureas, and α-Substituted Ketoximes to Nitrile Compounds
    Bulletin of the Chemical Society of Japan, vol. 80, no. 2, pp. 400–406, 2007
  18. Recent Progress in Selective Additions of Organometal Reagents to Carbonyl Compounds
    Current Organic Chemistry, vol. 11, no. 2, pp. 127–157, 2007
  19. Design of Chiral Macrocyclic Complexes Based on trans-Chelation of n:n Metal–Bidentate P,N- or N,N-Ligands
    Chemistry Letters, vol. 35, no. 2, pp. 172–173, 2006
  20. Enantioselective Dialkylzinc Addition to Aldehydes Catalyzed by Chiral Zn(II)-BINOLates Bearing Phosphonates and Phosphoramides in the 3,3â?²-Positions
    Synlett, vol. 2006, no. 11, pp. 1762–1764, 2006
  21. Organic Letters, vol. 8, no. 7, pp. 1431–1434, 2006
  22. Organic Letters, vol. 8, no. 11, pp. 2229–2232, 2006
  23. Organic Letters, vol. 8, no. 9, pp. 1921–1924, 2006
  24. Organic Letters, vol. 8, no. 15, pp. 3175–3178, 2006
  25. Organic Letters, vol. 8, no. 24, pp. 5649–5652, 2006
  26. Journal of the American Chemical Society, vol. 128, no. 31, pp. 9998–9999, 2006
  27. The Journal of Organic Chemistry, vol. 71, no. 17, pp. 6474–6484, 2006
  28. Bulky diarylammonium arenesulfonates as mild and extremely active dehydrative ester condensation catalysts
    Tetrahedron, vol. 62, no. 2-3, pp. 422–433, 2006
  29. Crucial Role of the Conjugate Base for Silyl Lewis Acid Induced Mukaiyama Aldol Reactions
    European Journal of Organic Chemistry, vol. 2006, no. 8, pp. 1837–1844, 2006
  30. Special Session on Thoracic CAD
    International Journal of Computer Assisted Radiology and Surgery, vol. 1, no. S1, pp. 345–367, 2006
  31. Enantioselective Dielsâ??Alder Reaction of α-Acyloxyacroleins Catalyzed by Chiral 1,1â?²-Binaphthyl-2,2â?²-diammonium Salts
    Advanced Synthesis & Catalysis, vol. 348, no. 16-17, pp. 2457–2465, 2006
  32. Iron(III)â??Zirconium(IV) Combined Salt Immobilized onN-(Polystyrylbutyl)pyridinium Triflylimide as a Reusable Catalyst for a Dehydrative Esterification Reaction
    Advanced Synthesis & Catalysis, vol. 348, no. 12-13, pp. 1505–1510, 2006
  33. Synthesis of (all-rac)-?-Tocopherol in Supercritical Carbon Dioxide: Tuning of the Product Selectivity in Batch and Continuous-Flow Reactors
    Advanced Synthesis & Catalysis, vol. 347, no. 2-3, pp. 220–224, 2005
  34. Zr(IV)Fe(III), Ga(III), and Sn(IV) Binary Metal Complexes as Synergistic and Reusable Esterification Catalysts
    Advanced Synthesis & Catalysis, vol. 347, no. 10, pp. 1337–1340, 2005
  35. Enantioselective Addition of Organozinc Reagents to Aldehydes Catalyzed by 3,3â?²-Bis(diphenylphosphinoyl)-BINOL
    Advanced Synthesis & Catalysis, vol. 347, no. 11-13, pp. 1561–1568, 2005
  36. Organic Letters, vol. 7, no. 8, pp. 1601–1604, 2005
  37. Organic Letters, vol. 7, no. 10, pp. 1999–2002, 2005
  38. Organic Letters, vol. 7, no. 10, pp. 1971–1974, 2005
  39. Organic Letters, vol. 7, no. 22, pp. 5043–5046, 2005
  40. Organic Letters, vol. 7, no. 22, pp. 5047–5050, 2005
  41. Journal of the American Chemical Society, vol. 127, no. 12, pp. 4168–4169, 2005
  42. Journal of the American Chemical Society, vol. 127, no. 31, pp. 10776–10777, 2005
  43. Journal of the American Chemical Society, vol. 127, no. 30, pp. 10504–10505, 2005
  44. Journal of the American Chemical Society, vol. 127, no. 32, pp. 11240–11241, 2005
  45. Biomimetic synthesis of acid-sensitive (â??)- and (+)-caparrapi oxides, (â??)- and (+)-8-epicaparrapi oxides, and (+)-dysifragin induced by artificial cyclases
    Bioorganic & Medicinal Chemistry, vol. 13, no. 17, pp. 5055–5065, 2005
  46. Organic Letters, vol. 7, no. 4, pp. 573–576, 2005
  47. Facile Synthesis of Aryl- and Alkyl-bis(trifluoromethylsulfonyl)methanes
    Bulletin of the Chemical Society of Japan, vol. 78, no. 8, pp. 1401–1410, 2005
  48. Organic Letters, vol. 6, no. 15, pp. 2551–2554, 2004
  49. Organic Letters, vol. 6, no. 12, pp. 1983–1986, 2004
  50. Journal of the American Chemical Society, vol. 126, no. 39, pp. 12212–12213, 2004
  51. Journal of the American Chemical Society, vol. 126, no. 36, pp. 11122–11123, 2004
  52. Water-Tolerant and Reusable Catalysts for Direct Ester Condensation between Equimolar Amounts of Carboxylic Acids and Alcohols
    Advanced Synthesis & Catalysis, vol. 346, no. 11, pp. 1275–1279, 2004
  53. Asymmetric Direct Aldol Reaction Assisted by Water and a Proline-Derived Tetrazole Catalyst
    Angewandte Chemie International Edition, vol. 43, no. 15, pp. 1983–1986, 2004
  54. Chiral Molecular Recognition by Aluminum Tris(2,6-diphenylphenoxide) in an Asymmetric 1,4-Addition
    Angewandte Chemie International Edition, vol. 43, no. 8, pp. 994–997, 2004
  55. Trimethylsilyl Pentafluorophenylbis(trifluoromethanesulfonyl)methide as a Super Lewis Acid Catalyst for the Condensation of Trimethylhydroquinone with Isophytol
    Angewandte Chemie International Edition, vol. 42, no. 46, pp. 5731–5733, 2003
  56. New bulky chiral Lewis acid catalyst: 3,3?-di(2-mesitylethynyl)binaphthol-titanium(iv) complex
    Chirality, vol. 15, no. 2, pp. 135–138, 2003
  57. Journal of the American Chemical Society, vol. 125, no. 1, pp. 24–25, 2003
  58. A New Method for the Preparation of Aluminum and Titanium Tris(2,6-diphenylphenoxide) Reagents and Their Application in Organic Synthesis
    Chemistry Letters, vol. 32, no. 11, pp. 1006–1007, 2003
  59. Crucial role of the ligand of silyl Lewis acid in the Mukaiyama aldol reactionElectronic supplementary information (ESI) available: experimental section. See http://www.rsc.org/suppdata/cc/b2/b203838b/
    Chemical Communications, no. 15, pp. 1564–1565, 2002
  60. Enantio- and Diastereoselective Stepwise Cyclization of Polyprenoids Induced by Chiral and Achiral LBAs. A New Entry to (-)-Ambrox, (+)-Podocarpa-8,11,13-triene Diterpenoids, and (-)-Tetracyclic Polyprenoid of Sedimentary Origin
    Journal of the American Chemical Society, vol. 124, no. 14, pp. 3647–3655, 2002
  61. The Journal of Organic Chemistry, vol. 67, no. 15, pp. 5124–5137, 2002
  62. Rhenium(VII) Oxo Complexes as Extremely Active Catalysts in the Dehydration of Primary Amides and Aldoximes to Nitriles
    Angewandte Chemie International Edition, vol. 41, no. 16, p. 2983, 2002
  63. Chiral Proton Donor Reagents: Tin Tetrachloride?Coordinated Optically Active Binaphthol Derivatives
    The Chemical Record, vol. 2, no. 3, pp. 177–188, 2002
  64. Direct ester condensation from a 1:1 mixture of carboxylic acids and alcohols catalyzed by hafnium(IV) or zirconium(IV) salts
    Tetrahedron, vol. 58, no. 41, pp. 8179–8188, 2002
  65. Polystyrene-Bound Tetrafluorophenylbis(triflyl)methane as an Organic-Solvent-Swellable and Strong Brønsted Acid Catalyst The authors thank Mr. Shoichi Kondo for the single-crystal X-ray analysis. Sodium triflate was generously donated by Central Glass Co., Ltd., Japan. The authors also acknowledge Dr. Yuko Wasada and Dr. Manabu Kubota for their helpful discussions on the theoretical calculations.
    Angewandte Chemie International Edition, vol. 40, no. 21, p. 4077, 2001
  66. Enantioselective Biomimetic Cyclization of Homo(polyprenyl)arenes. A New Entry to (+)-Podpcarpa-8,11,13-triene Diterpenoids and (-)-Tetracyclic Polyprenoid of Sedimentary Origin
    Journal of the American Chemical Society, vol. 123, no. 7, pp. 1505–1506, 2001
  67. Asymmetric Synthesis of (R)-Limonene and (S)-Cembrene-A by an Intramolecular Cyclization Reaction Using a Chiral Leaving Group
    Synlett, vol. 2001, no. 07, pp. 1113–1116, 2001
  68. A Green Method for the Selective Esterification of Primary Alcohols in the Presence of Secondary Alcohols or Aromatic Alcohols
    Synlett, vol. 2001, no. 07, pp. 1117–1120, 2001
  69. 3,5-Bis(perfluorodecyl)phenylboronic Acid as an Easily Recyclable Direct Amide Condensation Catalyst
    Synlett, vol. 2001, no. 09, pp. 1371–1374, 2001
  70. A High Yield Procedure for the Me3SiNTf2-Induced Carbon-Carbon Bond-Forming Reactions of Silyl Nucleophiles with Carbonyl Compounds: The Importance of Addition Order and Solvent Effects
    Synlett, vol. 2001, no. 12, pp. 1851–1854, 2001
  71. Removal of Palladium(II) from Aqueous and Organic Solutions by Polystyrene-bound Trimercaptotriazine.
    Chemistry Letters, no. 10, pp. 1218–1219, 2000
  72. Direct Condensation of Carboxylic Acids with Alcohols Catalyzed by Hafnium(IV) Salts
    Science, vol. 290, no. 5494, pp. 1140–1142, 2000
  73. Journal of the American Chemical Society, vol. 122, no. 34, pp. 8120–8130, 2000
  74. Journal of the American Chemical Society, vol. 122, no. 34, pp. 8131–8140, 2000
  75. Macromolecules, vol. 33, no. 10, pp. 3511–3513, 2000
  76. Journal of Organic Chemistry, vol. 65, no. 26, pp. 9125–9128, 2000
  77. Pyrolysis of benzenediazonium bis(trifluoromethanesulfonyl)methide
    Journal of Fluorine Chemistry, vol. 106, no. 2, pp. 139–141, 2000
  78. Arylboron Compounds as Acid Catalysts in Organic Synthetic Transformations
    European Journal of Organic Chemistry, vol. 1999, no. 3, pp. 527–538, 1999
  79. Journal of the American Chemical Society, vol. 121, no. 33, pp. 7720–7721, 1999
  80. A New and Extremely Active Corey's Chiral Oxazaborolidine Catalyst
    Synlett, vol. 1999, no. 8, pp. 1283–1285, 1999
  81. Rational Design of a New Chiral Lewis Acid Catalyst for Enantioselective Diels-Alder Reaction: Optically Active 2-Dichloroboryl-1,1'-binaphthyl
    Synlett, vol. 1998, no. 10, pp. 1053–1056, 1998
  82. Journal of the American Chemical Society, vol. 120, no. 28, pp. 6920–6930, 1998
  83. Journal of Organic Chemistry, vol. 62, no. 10, pp. 3026–3027, 1997
  84. Journal of Organic Chemistry, vol. 62, no. 17, pp. 5664–5665, 1997
  85. First Enantioselective Protonation of Prochiral Allyltrimethyltins Using Lewis Acid Assisted Chiral Brønsted Acids
    Synlett, vol. 1997, no. 7, pp. 758–760, 1997
  86. A New Scandium Complex as an Extremely Active Acylation Catalyst
    Synlett, vol. 1996, no. 03, pp. 265–266, 1996
  87. Scandium Trifluoromethanesulfonimide and Scandium Trifluoromethanesulfonate as Extremely Active Acetalization Catalysts
    Synlett, vol. 1996, no. 09, pp. 839–841, 1996
  88. Journal of Organic Chemistry, vol. 61, no. 14, pp. 4560–4567, 1996
  89. Journal of Organic Chemistry, vol. 61, no. 13, pp. 4196–4197, 1996
  90. Journal of the American Chemical Society, vol. 118, no. 6, pp. 1569–1570, 1996
  91. Journal of the American Chemical Society, vol. 118, no. 50, pp. 12854–12855, 1996
  92. Stereospecific annulation of hydroxy vinyl ethers. Synthetic application to polyfunctionalized cyclic compounds
    Tetrahedron, vol. 52, no. 21, pp. 7297–7320, 1996
  93. Asymmetric hetero Diels-Alder reaction catalyzed by stable and easily prepared CAB catalysts
    Tetrahedron, vol. 50, no. 42, pp. 979–988, 1994
  94. Asymmetric hetero Diels-Alder reaction catalyzed by stable and easily prepared CAB catalysts
    Tetrahedron, vol. 50, no. 15, p. 4555, 1994
  95. Journal of the American Chemical Society, vol. 116, no. 4, pp. 1561–1562, 1994
  96. Journal of the American Chemical Society, vol. 116, no. 23, pp. 10520–10524, 1994
  97. Journal of the American Chemical Society, vol. 116, no. 24, pp. 11179–11180, 1994
  98. Journal of Organic Chemistry, vol. 58, no. 15, pp. 3791–3793, 1993
  99. Journal of Organic Chemistry, vol. 58, no. 24, pp. 6917–6919, 1993
  100. Catalytic enantioselective Diels-Alder reactions using titanium complexes of cis-N-sulfonyl-2-amino-1-indanols
    Tetrahedron Letters, vol. 34, no. 52, pp. 8399–8402, 1993
  101. Journal of the American Chemical Society, vol. 115, no. 22, pp. 10412–10413, 1993
  102. Journal of the American Chemical Society, vol. 115, no. 23, pp. 10695–10704, 1993
  103. Journal of the American Chemical Society, vol. 115, no. 24, pp. 11490–11495, 1993
  104. Highly enantioselective catalytic Diels-Alder addition promoted by a chiral bis(oxazoline)-magnesium complex
    Tetrahedron Letters, vol. 33, no. 45, pp. 6807–6810, 1992
  105. Fed-batch culture automated by uses of continuously measured cell concentration and culture volume
    Biotechnology and Bioengineering, vol. 39, no. 5, pp. 550–555, 1992
  106. Journal of Organic Chemistry, vol. 55, no. 23, pp. 5814–5815, 1990
  107. Journal of Organic Chemistry, vol. 55, no. 25, pp. 6107–6115, 1990
  108. Chiral aryl grignard reagents-generation and reactions with carbonyl compounds.
    Bulletin of the Chemical Society of Japan, vol. 62, no. 11, pp. 3736–3738, 1989