Radu Silaghi-Dumitrescu obtained his first PhD degree in 2004 from the University of Georgia in Athens (GA) in the USA, working on non-heme iron proteins involved in oxidative and nitrosative stress in bacteria. He obtained a second PhD degree at the “Babes-Bolyai” University in Romania on computational aspects of small molecule activation by metalloproteins, in 2005. After a post-doctoral stage (2004-2006) at the University of Essex (Colchester, UK) on hemoglobin-based blood substitutes he took up an Associate Professor position at the “Babes-Bolyai” University in 2007. Since 2011 he is also a co-director of the Institute of Technology and a co-director of the Center for Molecular Modeling and Computational Quantum Chemistry of at the same university, and a member of the Biochemistry and Molecular Biology Commissions of the Romanian National Council for Scientific Research and of the National Council for Accreditation of University Degrees and Titles. He is currently teaching computational chemistry, bioinorganic chemistry, biochemistry, clinical chemistry and immunology. His current research interests are centered on small molecule activation by metalloproteins, with focus on unusual oxidation states and with ramifications into oxidative and nitrosative stress, blood substitutes, anticancer drugs, natural extracts with antioxidant and biological effects, redox reactions in dental materials, and interactions at the interface between nanomaterials and biomolecules. The tools currently used for this research in his laboratory include computational chemistry, UV-vis, EPR, vibrational and NMR spectroscopy, mass spectrometry, stopped-flow, rapid freeze-quench, protein cloning, overexpression and purification, protein chemical derivatization. Radu Silaghi-Dumitrescu has co-authored over 100 scientific articles and 6 books.
Biography Updated on 21 May 2012